Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Stephen E Bottoms"'
Publikováno v:
PLoS Pathogens, Vol 3, Iss 9, Pp 1208-1219 (2007)
The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been reported. We have investigated the role of SAP for i
Externí odkaz:
https://doaj.org/article/f93de9d292c4461abacca73393dcf03b
Autor:
Maria D I Manunta, Robin J McAnulty, Aristides D Tagalakis, Stephen E Bottoms, Frederick Campbell, Helen C Hailes, Alethea B Tabor, Geoffrey J Laurent, Christopher O'Callaghan, Stephen L Hart
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26768 (2011)
Gene therapy mediated by synthetic vectors may provide opportunities for new treatments for cystic fibrosis (CF) via aerosolisation. Vectors for CF must transfect the airway epithelium efficiently and not cause inflammation so they are suitable for r
Externí odkaz:
https://doaj.org/article/b4e704dda6444ec3ac8d0e904dd593d2
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9674 (2010)
The TGF-beta family of mediators are thought to play important roles in the regulation of inflammation and airway remodelling in asthma. All three mammalian isoforms of TGF-beta, TGF-beta(1-3), are expressed in the airways and TGF-beta(1) and -beta(2
Externí odkaz:
https://doaj.org/article/56ced0fde23140a2a144511a453a7052
Autor:
Lorenzo Biassoni, Robin J. McAnulty, Livia Tossici-Bolt, Stephen L. Hart, Stephen E. Bottoms, John S. Fleming, Deborah Ridout, Maria Manunta, Geoffrey J. Laurent, Christopher O'Callaghan, Jing Jin, Amy R. McDowell
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:471-480
Receptor-targeted nanocomplexes are nonviral vectors developed for gene delivery to the airway epithelium for the treatment of pulmonary disease associated with cystic fibrosis. The present study aimed to optimize the delivery of the nanocomplex by n
Autor:
Stephen L. Hart, Stephen E. Bottoms, Michele J. Writer, Christopher O'Callaghan, Martin Elbs, Aristides D. Tagalakis, Helen C. Hailes, John B. Wong, Adam Jaffe, Robin J. McAnulty, James Devaney, Alethea B. Tabor
Publikováno v:
Molecular Therapy. 16:907-915
Synthetic vectors for cystic fibrosis (CF) gene therapy are required that efficiently and safely transfect airway epithelial cells, rather than alveolar epithelial cells or macrophages, and that are nonimmunogenic, thus allowing for repeated delivery
Publikováno v:
PLoS Pathogens, Vol 3, Iss 9, Pp 1208-1219 (2007)
PLoS Pathogens
PLoS Pathogens
The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been reported. We have investigated the role of SAP for i
Autor:
Stephen L. Hart, Robin J. McAnulty, Caroline P.D. Wheeler-Jones, Carmel B. Nanthakumar, R. Gisli Jenkins, G Bellingan, Stephen E. Bottoms, Martyn Foster, Geoffrey J. Laurent, Danielle M. Copeman, Rebecca J. Hodges
Publikováno v:
The American Journal of Pathology. 165:1663-1676
Levels of prostaglandin E(2) (PGE(2)), a potent inhibitor of fibroblast function, are decreased in the lungs of patients with pulmonary fibrosis, which has been shown to be because of limited expression of cyclooxygenase-2 (COX-2). To further investi
Autor:
Helen Cauldwell, Geoffrey J. Laurent, Stephen E. Bottoms, H. Cooksley, Anthony Shock, Steven E. Mutsaers, G Bellingan, Ping Xu, Christopher Haslett
Publikováno v:
The Journal of Experimental Medicine
Macrophage clearance is essential for the resolution of inflammation. Much is known about how monocytes enter the inflammatory site but little is known about how resultant macro-phages are cleared. We have previously demonstrated that macrophage clea
Autor:
Jane E. Redford, Clifford H. Battram, Stephen E. Bottoms, Sharon Wicks, Martyn Foster, Paul Woodman, Stephen E Webber, Thomas J. Brown, Maria G. Belvisi
Publikováno v:
The Journal of Immunology. 166:1975-1982
Glucocorticoids (GCs) are the mainstay of asthma therapy; however, major side effects limit their therapeutic use. GCs influence the expression of genes either by transactivation or transrepression. The antiinflammatory effects of steroids are though
Autor:
Stephen E. Bottoms, Paul F. Mercer, Andrew J. Thorley, Andrew G. Nicholson, Toby M. Maher, Geoffrey J. Laurent, Iona Evans, Teresa D. Tetley, Rachel C. Chambers, Robin J. McAnulty
Rationale: Patients with idiopathic pulmonary fibrosis (IPF), a progressive disease with a dismal prognosis, exhibit an unexplained disparity of increased alveolar epithelial cell (AEC) apoptosis but reduced fibroblast apoptosis. Objectives: To exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b67db09dcc11fde1e63a2e8d0e4d4e
https://europepmc.org/articles/PMC2902759/
https://europepmc.org/articles/PMC2902759/