Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Stephen Douthwaite"'
Autor:
Agnieszka Sałamaszyńska-Guz, Pernille Kronholm Rasmussen, Małgorzata Murawska, Stephen Douthwaite
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
Campylobacter jejuni is a major cause of food poisoning worldwide, and remains the main infective agent in gastroenteritis and related intestinal disorders in Europe and the USA. As with all bacterial infections, the stages of adhesion to host tissue
Externí odkaz:
https://doaj.org/article/3774e262d26c422fba782771ea2a07bf
Autor:
Pascal Sirand-Pugnet, Damien Brégeon, Laure Béven, Catherine Goyenvalle, Alain Blanchard, Simon Rose, Henri Grosjean, Stephen Douthwaite, Djemel Hamdane, Valérie de Crécy-Lagard
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 587 (2020)
The C5-methylation of uracil to form 5-methyluracil (m5U) is a ubiquitous base modification of nucleic acids. Four enzyme families have converged to catalyze this methylation using different chemical solutions. Here, we investigate the evolution of 5
Externí odkaz:
https://doaj.org/article/df92b399a153424d80ce818ba6118dcf
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Strains of the Pasteurellaceae bacteria Pasteurella multocida and Mannheimia haemolytica are major etiological agents of bovine respiratory disease (BRD). Treatment of BRD with antimicrobials is becoming more challenging due to the increasing occurre
Externí odkaz:
https://doaj.org/article/85b6ec7cbeab466e8ecd568f2f518c93
Autor:
Agnieszka Sałamaszyńska-Guz, Simon Rose, Claus A. Lykkebo, Bartłomiej Taciak, Paweł Bącal, Tomasz Uśpieński, Stephen Douthwaite
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2018)
Numerous bacterial pathogens express an ortholog of the enzyme TlyA, which is an rRNA 2′-O-methyltransferase associated with resistance to cyclic peptide antibiotics such as capreomycin. Several other virulence traits have also been attributed to T
Externí odkaz:
https://doaj.org/article/a7bbf32ce6f44755a270e01bd40b5747
Publikováno v:
Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, 2020, 75 (2), pp.371-378. ⟨10.1093/jac/dkz441⟩
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2020, 75 (2), pp.371-378. ⟨10.1093/jac/dkz441⟩
Guerin, F, Rose, S, Cattoir, V & Douthwaite, S 2020, ' Helcococcus kunzii methyltransferase Erm(47) responsible for MLSB resistance is induced by diverse ribosome-targeting antibiotics ', Journal of Antimicrobial Chemotherapy, vol. 75, no. 2, pp. 371-378 . https://doi.org/10.1093/jac/dkz441
Journal of Antimicrobial Chemotherapy, 2020, 75 (2), pp.371-378. ⟨10.1093/jac/dkz441⟩
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2020, 75 (2), pp.371-378. ⟨10.1093/jac/dkz441⟩
Guerin, F, Rose, S, Cattoir, V & Douthwaite, S 2020, ' Helcococcus kunzii methyltransferase Erm(47) responsible for MLSB resistance is induced by diverse ribosome-targeting antibiotics ', Journal of Antimicrobial Chemotherapy, vol. 75, no. 2, pp. 371-378 . https://doi.org/10.1093/jac/dkz441
ObjectivesTo determine the mechanism of induction of erm(47) and its atypical expression in the Gram-positive opportunistic pathogen Helcococcus kunzii, where it confers resistance to a subset of clinically important macrolide, lincosamide and strept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba84bd8d9c09ac1561b393533713072
https://univ-rennes.hal.science/hal-02365113/document
https://univ-rennes.hal.science/hal-02365113/document
Autor:
Stephen Douthwaite, Finn Kirpekar, Jesper F. Havelund, Simon Rose, Harald Huber, Sylvie Auxilien, Henri Grosjean
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2020, 48 (12), pp.6906--6918. ⟨10.1093/nar/gkaa411⟩
Rose, S, Auxilien, S, Havelund, J F, Kirpekar, F, Huber, H, Grosjean, H & Douthwaite, S 2020, ' The hyperthermophilic partners Nanoarchaeum and Ignicoccus stabilize their tRNA T-loops via different but structurally equivalent modifications ', Nucleic acids research, vol. 48, no. 12, pp. 6906-6918 . https://doi.org/10.1093/nar/gkaa411
Nucleic Acids Research, 2020, 48 (12), pp.6906--6918. ⟨10.1093/nar/gkaa411⟩
Rose, S, Auxilien, S, Havelund, J F, Kirpekar, F, Huber, H, Grosjean, H & Douthwaite, S 2020, ' The hyperthermophilic partners Nanoarchaeum and Ignicoccus stabilize their tRNA T-loops via different but structurally equivalent modifications ', Nucleic acids research, vol. 48, no. 12, pp. 6906-6918 . https://doi.org/10.1093/nar/gkaa411
Place: Oxford Publisher: Oxford Univ Press WOS:000574288800042; The universal L-shaped tertiary structure of tRNAs is maintained with the help of nucleotide modifications within the D- and T-loops, and these modifications are most extensive within hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b76e995c76b279dd947f01251ee9ff
https://hal.archives-ouvertes.fr/hal-02968376
https://hal.archives-ouvertes.fr/hal-02968376
Autor:
Laure Béven, Djemel Hamdane, Catherine Goyenvalle, Simon Rose, Henri Grosjean, Damien Brégeon, Alain Blanchard, Stephen Douthwaite, Pascal Sirand-Pugnet, Valérie de Crécy-Lagard
Publikováno v:
Biomolecules
Biomolecules, MDPI, 2020, 10 (4), pp.587. ⟨10.3390/biom10040587⟩
Biomolecules, 2020, 10 (4), pp.587. ⟨10.3390/biom10040587⟩
Sirand-Pugnet, P, Brégeon, D, Béven, L, Goyenvalle, C, Blanchard, A, Rose, S, Grosjean, H, Douthwaite, S, Hamdane, D & Crécy-Lagard, V D 2020, ' Reductive Evolution and Diversification of C5-Uracil Methylation in the Nucleic Acids of Mollicutes ', Biomolecules, vol. 10, no. 4, 587 . https://doi.org/10.3390/biom10040587
Volume 10
Issue 4
Biomolecules, Vol 10, Iss 587, p 587 (2020)
Biomolecules, MDPI, 2020, 10 (4), pp.587. ⟨10.3390/biom10040587⟩
Biomolecules, 2020, 10 (4), pp.587. ⟨10.3390/biom10040587⟩
Sirand-Pugnet, P, Brégeon, D, Béven, L, Goyenvalle, C, Blanchard, A, Rose, S, Grosjean, H, Douthwaite, S, Hamdane, D & Crécy-Lagard, V D 2020, ' Reductive Evolution and Diversification of C5-Uracil Methylation in the Nucleic Acids of Mollicutes ', Biomolecules, vol. 10, no. 4, 587 . https://doi.org/10.3390/biom10040587
Volume 10
Issue 4
Biomolecules, Vol 10, Iss 587, p 587 (2020)
The C5-methylation of uracil to form 5-methyluracil (m5U) is a ubiquitous base modification of nucleic acids. Four enzyme families have converged to catalyze this methylation using different chemical solutions. Here, we investigate the evolution of 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd5987e6d5773d0f47a19ceee3ec349
https://hal.archives-ouvertes.fr/hal-02547879
https://hal.archives-ouvertes.fr/hal-02547879
Publikováno v:
Cellular Microbiology
Sałamaszyńska-Guz, A, Serafińska, I, Bącal, P & Douthwaite, S 2020, ' Virulence properties of Campylobacter jejuni are enhanced by displaying a mycobacterial TlyA methylation pattern in its rRNA ', Cellular Microbiology, vol. 22, no. 7, e13199 . https://doi.org/10.1111/cmi.13199
Sałamaszyńska-Guz, A, Serafińska, I, Bącal, P & Douthwaite, S 2020, ' Virulence properties of Campylobacter jejuni are enhanced by displaying a mycobacterial TlyA methylation pattern in its rRNA ', Cellular Microbiology, vol. 22, no. 7, e13199 . https://doi.org/10.1111/cmi.13199
Campylobacter jejuni is a bacterial pathogen that is generally acquired as a zoonotic infection from poultry and animals. Adhesion of C. jejuni to human colorectal epithelial cells is weakened after loss of its cj0588 gene. The Cj0588 protein belongs
Autor:
Alexander S. Mankin, Stephen Douthwaite, Nora Vázquez-Laslop, Sung Ryeol Park, Mashal M. Almutairi, Douglas A. Hansen, Simon Rose, David H. Sherman
Publikováno v:
Almutairi, M M, Park, S R, Rose, S, Hansen, D A, Vázquez-Laslop, N, Douthwaite, S, Sherman, D H & Mankin, A S 2015, ' Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides ', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 42, pp. 12956-12961 . https://doi.org/10.1073/pnas.1512090112
Ketolides are promising new antimicrobials effective against a broad range of Gram-positive pathogens, in part because of the low propensity of these drugs to trigger the expression of resistance genes. A natural ketolide pikromycin and a related com
Autor:
Gilles P. van Wezel, Marten Boetzer, Stephen Douthwaite, Walter Pirovano, Nelson E. Arenas, Mariana Avalos
Publikováno v:
Genome Announcements
Genome Announcements, 6(18). American Society for Microbiology
Avalos, M, Boetzer, M, Pirovano, W, Arenas, N E, Douthwaite, S & van Wezel, G P 2018, ' Complete Genome Sequence of Escherichia coli AS19, an Antibiotic-Sensitive Variant of E. coli Strain B REL606 ', Genome Announcements, vol. 6, no. 18, e00385-18 . https://doi.org/10.1128/genomeA.00385-18
Genome Announcements, 6(18). American Society for Microbiology
Avalos, M, Boetzer, M, Pirovano, W, Arenas, N E, Douthwaite, S & van Wezel, G P 2018, ' Complete Genome Sequence of Escherichia coli AS19, an Antibiotic-Sensitive Variant of E. coli Strain B REL606 ', Genome Announcements, vol. 6, no. 18, e00385-18 . https://doi.org/10.1128/genomeA.00385-18
The chemically mutagenized Escherichia coli strain AS19 was isolated on the basis of its enhanced sensitivity to different antibiotics, in particular to actinomycin. The strain was later modified to study rRNA modifications that confer antibiotic res