Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Stephen David Lindell"'
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2937-2942
Modified C-nucleosides and nucleotides with an enhanced tendency to undergo covalent hydration are of interest as potential inhibitors of adenosine deaminase (ADA) and AMP deaminase, respectively. In a search for such compounds we have synthesized 6-
Synthesis of C-ribosyl imidazo[2,1-f ][1,2,4]triazines as inhibitors of adenosine and AMP deaminases
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2929-2936
The 3-β-D-ribofuranoside 6 of the new imidazo[2,1-f][1,2,4]triazine 27 is isomeric and isoelectronic with the nucleoside deaminoformycin 1 which is a good inhibitor of adenosine deaminase (ADA) while its 5′-monophosphate 2 is a good inhibitor of a
Autor:
Jane E. Dancer, Brian A. Moloney, Brian D. Hewitt, Stephen David Lindell, Christopher G. Earnshaw, Philip J. Dudfield
Publikováno v:
ChemInform. 30
Carbocylic coformycin (4) is a potent herbicide whose primary mode of action involves inhibition of adenosine 5′-monophosphate deaminase (AMPDA) following phosphorylation of the 5′-hydroxyl group in vivo. The search for more stable and accessible
Publikováno v:
ChemInform. 31
The 3-β-D-ribofuranoside 6 of the new imidazo[2,1-f][1,2,4]triazine 27 is isomeric and isoelectronic with the nucleoside deaminoformycin 1 which is a good inhibitor of adenosine deaminase (ADA) while its 5′-monophosphate 2 is a good inhibitor of a
Publikováno v:
ChemInform. 31
Modified C-nucleosides and nucleotides with an enhanced tendency to undergo covalent hydration are of interest as potential inhibitors of adenosine deaminase (ADA) and AMP deaminase, respectively. In a search for such compounds we have synthesized 6-
Autor:
Floris L. van Delft, Floris P. J. T. Rutjes, Jörg Tiebes, Harald Jakobi, Stephen David Lindell, Valeria De Matteis
Publikováno v:
Journal of Organic Chemistry, 71, 7527-7532
Journal of Organic Chemistry, 71, 20, pp. 7527-7532
Journal of Organic Chemistry, 71, 20, pp. 7527-7532
A ring-closing metathesis mediated pathway to trifluoromethyl-containing piperidines is detailed. This involves the development of a synthetic route to a new (trifluoromethyl)allylating reagent via a Diels-Alder/retro-Diels-Alder strategy, its applic
Autor:
Brian A. Moloney, Christopher G. Earnshaw, Stephen David Lindell, Philip J. Dudfield, Jane E. Dancer, Brian D. Hewitt
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(14)
Carbocylic coformycin (4) is a potent herbicide whose primary mode of action involves inhibition of adenosine 5′-monophosphate deaminase (AMPDA) following phosphorylation of the 5′-hydroxyl group in vivo. The search for more stable and accessible