Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Stephen D. Swenson"'
Autor:
Radu O Minea, Tuan Cao Duc, Stephen D Swenson, Hee-Yeon Cho, Mickey Huang, Hannah Hartman, Florence M Hofman, Axel H Schönthal, Thomas C Chen
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238238 (2020)
The prognosis for patients with glioblastoma (GB) remains grim. Concurrent temozolomide (TMZ) radiation-the cornerstone of glioma control-extends the overall median survival of GB patients by only a few months over radiotherapy alone. While these sur
Externí odkaz:
https://doaj.org/article/06b1342876a949aa97d7626567027847
Autor:
Thomas C. Chen, Florence M. Hofman, Axel H. Schönthal, Nagore I. Marín-Ramos, Mengting Ou, Rochelle A. Fayngor, Stephen D. Swenson, Weijun Wang, Thu Zan Thein, Hee-Yeon Cho
Human astrocytes produce TRAIL.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716e3cd8913f65a783ccf58f33c2b19f
https://doi.org/10.1158/1535-7163.22510404.v1
https://doi.org/10.1158/1535-7163.22510404.v1
Autor:
Florence M. Hofman, Thomas C. Chen, Axel H. Schönthal, Weijun Wang, Stephen D. Swenson, Hee-Yeon Cho, Thu Zan Thein, Nagore I. Marín-Ramos
Supplementary Figure 1. NEO212 is a conjugate of POH and TMZ; Supplementary Figure 2. NEO212 impairs GSC migration without affecting cell viability; Supplementary Figure 3. NEO212 impairs the invasion of several primary cultures of GBM cells and GSCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b2dc77f8e37100078cf20220603ea2
https://doi.org/10.1158/1535-7163.22505070
https://doi.org/10.1158/1535-7163.22505070
Autor:
Thomas C. Chen, Florence M. Hofman, Axel H. Schönthal, Nagore I. Marín-Ramos, Mengting Ou, Rochelle A. Fayngor, Stephen D. Swenson, Weijun Wang, Thu Zan Thein, Hee-Yeon Cho
Glioblastoma (GBM) is a highly aggressive primary brain tumor with a poor prognosis. Treatment with temozolomide, standard of care for gliomas, usually results in drug resistance and tumor recurrence. Therefore, there is a great need for drugs that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5210bf57341432b354501c58572df7f4
https://doi.org/10.1158/1535-7163.c.6539610
https://doi.org/10.1158/1535-7163.c.6539610
Autor:
Florence M. Hofman, Thomas C. Chen, Axel H. Schönthal, Weijun Wang, Stephen D. Swenson, Hee-Yeon Cho, Thu Zan Thein, Nagore I. Marín-Ramos
Glioblastoma multiforme is a malignant brain tumor noted for its extensive vascularity, aggressiveness, and highly invasive nature, suggesting that cell migration plays an important role in tumor progression. The poor prognosis in GBM is associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c11dc34f800826598371576e2152c1b
https://doi.org/10.1158/1535-7163.c.6537939.v1
https://doi.org/10.1158/1535-7163.c.6537939.v1
Publikováno v:
Handbook of Venoms and Toxins of Reptiles ISBN: 9780429054204
Handbook of Venoms and Toxins of Reptiles
Handbook of Venoms and Toxins of Reptiles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0883601087d016834d03fdf6c3339f1b
https://doi.org/10.1201/9780429054204-27
https://doi.org/10.1201/9780429054204-27
Autor:
Radu O Minea, Corey M Helchowski, Samuel J Zidovetzki, Fritz K Costa, Stephen D Swenson, Francis S Markland
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10929 (2010)
Similar to other integrin-targeting strategies, disintegrins have previously shown good efficacy in animal cancer models with favorable pharmacological attributes and translational potential. Nonetheless, these polypeptides are notoriously difficult
Externí odkaz:
https://doaj.org/article/14648aebbdc544c5988dfa92d26ec79e
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2068
Integrin targeting has been shown to be an effective approach for anticancer therapy. We engineered a recombinant disintegrin, vicrostatin (VCN), that binds with high affinity and specificity to the Arg-Gly-Asp (RGD) class of integrins, including αv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9060083da82e859c8f022efdf8875980
https://pubmed.ncbi.nlm.nih.gov/31576529
https://pubmed.ncbi.nlm.nih.gov/31576529
Publikováno v:
Cancer Research. 81:PO030-PO030
Disintegrins are disulfide-rich peptides, many containing an Arg-Gly-Asp (RGD) motif. They hold significant translational potential as anti-cancer agents based on their high-affinity/high-specificity interaction with tumor integrins and desirable pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e402d4d619d5c3b53d6c17d0128f610c
https://doi.org/10.1158/1538-7445.tme21-po030
https://doi.org/10.1158/1538-7445.tme21-po030
Publikováno v:
Venom Genomics and Proteomics ISBN: 9789400764156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1557a3c79ac43916cdc969885d3c520c
https://doi.org/10.1007/978-94-007-6416-3_37
https://doi.org/10.1007/978-94-007-6416-3_37