Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Stephen D. H. Hsu"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract In this paper we characterize the performance of linear models trained via widely-used sparse machine learning algorithms. We build polygenic scores and examine performance as a function of training set size, genetic ancestral background, an
Externí odkaz:
https://doaj.org/article/f45c50f7c3764934a2005a9c27f3cf63
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract We construct a polygenic health index as a weighted sum of polygenic risk scores for 20 major disease conditions, including, e.g., coronary artery disease, type 1 and 2 diabetes, schizophrenia, etc. Individual weights are determined by popul
Externí odkaz:
https://doaj.org/article/5816da80f15549efb8dc47ae9549ba2b
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Abstract We construct risk predictors using polygenic scores (PGS) computed from common Single Nucleotide Polymorphisms (SNPs) for a number of complex disease conditions, using L1-penalized regression (also known as LASSO) on case-control data from U
Externí odkaz:
https://doaj.org/article/d0bbe05be1ad42e9b5b0912d11a4bc34
Autor:
Xavier Calmet, Stephen D. H. Hsu
In this invited review, we describe Hawking's information paradox and a recently proposed resolution of it. Explicit calculations demonstrate the existence of quantum hair on black holes, meaning that the quantum state of the external graviton field
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4e6679080813c15dcb987161a3f26a
http://arxiv.org/abs/2207.08671
http://arxiv.org/abs/2207.08671
We construct a polygenic health index as a weighted sum of polygenic risk scores for 20 major disease conditions, including, e.g., coronary artery disease, type 1 and 2 diabetes, schizophrenia, etc. Individual weights are determined by population-lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76ce5e87cf85c5e63bf5e91ff3cef31a
https://doi.org/10.1101/2022.06.15.22276102
https://doi.org/10.1101/2022.06.15.22276102
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2467
Decoding the genome confers the capability to predict characteristics of the organism (phenotype) from DNA (genotype). We describe the present status and future prospects of genomic prediction of complex traits in humans. Some highly heritable comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c10d81beb3bc4f0998ddceb4f6514bf
https://pubmed.ncbi.nlm.nih.gov/35451785
https://pubmed.ncbi.nlm.nih.gov/35451785
Autor:
Roman V. Buniy, Stephen D. H. Hsu
Publikováno v:
Foundations of Physics. 51
For any choice of initial state and weak assumptions about the Hamiltonian, large isolated quantum systems undergoing Schrodinger evolution spend most of their time in macroscopic superposition states. The result follows from von Neumann's 1929 Quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db37afb9f71136453e36fd271eaaf178
https://doi.org/10.1007/s10701-021-00477-2
https://doi.org/10.1007/s10701-021-00477-2
Autor:
Nathan R. Treff, Laurent C. A. M. Tellier, Jennifer Eccles, Louis Lello, Simon Fishel, Stephen D. H. Hsu
Publikováno v:
Genes
Volume 12
Issue 8
Genes, Vol 12, Iss 1105, p 1105 (2021)
Volume 12
Issue 8
Genes, Vol 12, Iss 1105, p 1105 (2021)
Machine learning methods applied to large genomic datasets (such as those used in GWAS) have led to the creation of polygenic risk scores (PRSs) that can be used identify individuals who are at highly elevated risk for important disease conditions, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab73c9da304e99aa87d2859ae4c3ac20
Publikováno v:
Genes
Volume 12
Issue 7
Genes, Vol 12, Iss 991, p 991 (2021)
Volume 12
Issue 7
Genes, Vol 12, Iss 991, p 991 (2021)
We use UK Biobank data to train predictors for 65 blood and urine markers such as HDL, LDL, lipoprotein A, glycated haemoglobin, etc. from SNP genotype. For example, our Polygenic Score (PGS) predictor correlates ∼0.76 with lipoprotein A level, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5da49850c3ce197d3c45e911a86b17a
Publikováno v:
N Engl J Med
Companies have recently begun to sell a new service to patients considering in vitro fertilization: embryo selection based on polygenic scores (ESPS). These scores represent individualized predictions of health and other outcomes derived from genomew
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3beae389810bf53cd5fca3c24c77ef8b
https://doi.org/10.1056/nejmc2113013
https://doi.org/10.1056/nejmc2113013