Susceptibility to disease (tropical theileriosis) is associated with differential expression of host genes that possess motifs recognised by a pathogen DNA binding protein

Autor: Stephen D. Larcombe, Paul Capewell, Kirsty Jensen, William Weir, Jane Kinnaird, Elizabeth J. Glass, Brian R. Shiels

Publikováno v: PLoS ONE, Vol 17, Iss 1 (2022)

Background Knowledge of factors that influence the outcome of infection are crucial for determining the risk of severe disease and requires the characterisation of pathogen-host interactions that have evolved to confer variable susceptibility to infe

Externí odkaz: https://doaj.org/article/daf4aa2bd3a748fcb88f6f82411b636b

When is a slender not a slender? The cell-cycle arrest and scarcity of slender parasites challenges the role of bloodstream trypanosomes in infection maintenance

Autor: Stephen D. Larcombe, Emma M. Briggs, Nick Savill, Balazs Szoor, Keith R. Matthews

SummaryThe development ofTrypanosoma bruceiin its mammalian host is marked by a distinct morphological change as replicative “slender” forms differentiate into cell-cycle arrested “stumpy” forms in a quorum-sensing dependent manner. Although

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a95a9fbce40c71845fc87068dd6ecb4
https://doi.org/10.1101/2023.04.06.535835

Identification of candidate transmission-blocking antigen genes in Theileria annulata and related vector-borne apicomplexan parasites

Autor: William Weir, Selin Hacilarlioglu, Zeeshan Durrani, Jane Kinnaird, Stephen D. Larcombe, Serkan Bakirci, Laetitia Lempereur, Hüseyin Bilgin Bilgiç, Joanne Thompson, Brian Shiels, Tülin Karagenç

Publikováno v: BMC Genomics, Vol 18, Iss 1, Pp 1-14 (2017)
Lempereur, L, Larcombe, S D, Durrani, Z, Karagenc, T, Bilgic, H, Bakirci, S, Hacilarlioglu, S, Kinnaird, J, Thompson, J, Weir, W & Shiels, B 2017, ' Identification of candidate transmission-blocking antigen genes in Theileria annulata and related vector-borne apicomplexan parasites ', BMC Genomics, vol. 18 . https://doi.org/10.1186/s12864-017-3788-1
BMC Genomics
BMC GENOMICS

Background Vector-borne apicomplexan parasites are a major cause of mortality and morbidity to humans and livestock globally. The most important disease syndromes caused by these parasites are malaria, babesiosis and theileriosis. Strategies for cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf270ff225dbb30a8c6de573354a0920
http://link.springer.com/article/10.1186/s12864-017-3788-1

Vector species-specific association between natural Wolbachia infections and avian malaria in black fly populations

Autor: Stephen D. Larcombe, Yoana Ivanova, Giovanni Bianco, Luke Woodford, Maeve Dale, Kathryn R. Elmer, Francesco Baldini, Fiona Rae, Heather M. Ferguson, Barbara Helm

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Artificial infection of mosquitoes with the endosymbiont bacteria Wolbachia can interfere with malaria parasite development. Therefore, the release of Wolbachia-infected mosquitoes has been proposed as a malaria control strategy. However, Wolbachia e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1c066f8fbfaae3cc4dfc4de28d4d5c
http://europepmc.org/articles/PMC5843599

PCR diagnosis of tick-borne pathogens in Maharashtra state, India indicates fitness cost associated with carrier infections is greater for crossbreed than native cattle breeds

Autor: S. W. Kolte, Stephen D. Larcombe, Ganesh Warthi, Swapnil P. Magar, Elizabeth Glass, Nitin V. Kurkure, Brian Shiels, Suresh Gulabrao Jadhao

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0174595 (2017)
PLoS ONE
Kolte, S W, Larcombe, S D, Jadhao, S G, Magar, S P, Warthi, G, Kurkure, N V, Glass, E J & Shiels, B R 2017, ' PCR diagnosis of tick-borne pathogens in Maharashtra state, India indicates fitness cost associated with carrier infections is greater for crossbreed than native cattle breeds ', PLoS ONE, vol. 12, no. 3, e0174595 . https://doi.org/10.1371/journal.pone.0174595

Tick-borne pathogens (TBP) are responsible for significant economic losses to cattle production, globally. This is particularly true in countries like India where TBP constrain rearing of high yielding Bos taurus, as they show susceptibility to acute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cc5bd04282f0acfb7a48260b92dea3
http://europepmc.org/articles/PMC5373575?pdf=render