Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Stephen Cusack"'
Autor:
Lucía Álvarez, Kevin Haubrich, Louisa Iselin, Laurent Gillioz, Vincenzo Ruscica, Karine Lapouge, Sandra Augsten, Ina Huppertz, Nila Roy Choudhury, Bernd Simon, Pawel Masiewicz, Mathilde Lethier, Stephen Cusack, Katrin Rittinger, Frank Gabel, Alexander Leitner, Gracjan Michlewski, Matthias W. Hentze, Frédéric H. T. Allain, Alfredo Castello, Janosch Hennig
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract TRIM25 is an RNA-binding ubiquitin E3 ligase with central but poorly understood roles in the innate immune response to RNA viruses. The link between TRIM25’s RNA binding and its role in innate immunity has not been established. Thus, we ut
Externí odkaz:
https://doaj.org/article/d8245675d28e4b2bbc482fdb79f08563
Autor:
Benoît Arragain, Tim Krischuns, Martin Pelosse, Petra Drncova, Martin Blackledge, Nadia Naffakh, Stephen Cusack
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Replication of influenza viral RNA depends on at least two viral polymerases, a parental replicase and an encapsidase, and cellular factor ANP32. ANP32 comprises an LRR domain and a long C-terminal low complexity acidic region (LCAR). Here w
Externí odkaz:
https://doaj.org/article/eb9333d58028408b951a16e109240b80
Autor:
Tim Krischuns, Benoît Arragain, Catherine Isel, Sylvain Paisant, Matthias Budt, Thorsten Wolff, Stephen Cusack, Nadia Naffakh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The current model is that the influenza virus polymerase (FluPol) binds either to host RNA polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its conformation and activity towards transcription or replic
Externí odkaz:
https://doaj.org/article/b3842536fde24ca59325f1c6a87e2e03
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Tilapia Lake Virus (TiLV), a recently discovered pathogen of tilapia fish, belongs to the Amnoonviridae family from the Articulavirales order. Its ten genome segments have characteristic conserved ends and encode proteins with no known homol
Externí odkaz:
https://doaj.org/article/3cb74a9debf7431389f6c4d2610d6433
Autor:
Etienne Dubiez, Erika Pellegrini, Maja Finderup Brask, William Garland, Anne-Emmanuelle Foucher, Karine Huard, Torben Heick Jensen, Stephen Cusack, Jan Kadlec
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113639- (2024)
Summary: The nuclear cap-binding complex (CBC) coordinates co-transcriptional maturation, transport, or degradation of nascent RNA polymerase II (Pol II) transcripts. CBC with its partner ARS2 forms mutually exclusive complexes with diverse “effect
Externí odkaz:
https://doaj.org/article/fdf272396eb54691b0d9368ff2138af8
Autor:
Anne-Emmanuelle Foucher, Leila Touat-Todeschini, Ariadna B. Juarez-Martinez, Auriane Rakitch, Hamida Laroussi, Claire Karczewski, Samira Acajjaoui, Montserrat Soler-López, Stephen Cusack, Cameron D. Mackereth, André Verdel, Jan Kadlec
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Unwanted RNA transcripts are targeted for degradation by nuclear complexes such as MTREC/PAXT. Here, the authors structurally and functionally characterized three interfaces of the scaffold protein Red1, providing mechanistic insights into conserved
Externí odkaz:
https://doaj.org/article/c277482d7e23417582ce5dd3cf5d0971
Autor:
Benoît Arragain, Quentin Durieux Trouilleton, Florence Baudin, Jan Provaznik, Nayara Azevedo, Stephen Cusack, Guy Schoehn, Hélène Malet
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
La Crosse is a human life threatening virus belonging to the Bunyavirales order. The structure of its polymerase solved in seven key active states by cryo-electron microscopy reveals the molecular mechanisms of viral RNA replication and transcription
Externí odkaz:
https://doaj.org/article/baf0b7f62a9c4fc8a3d6e52a3256d0b6
Publikováno v:
PLoS Pathogens, Vol 19, Iss 1, p e1011060 (2023)
Bunyaviruses are negative sense, single-strand RNA viruses that infect a wide range of vertebrate, invertebrate and plant hosts. WHO lists three bunyavirus diseases as priority diseases requiring urgent development of medical countermeasures highligh
Externí odkaz:
https://doaj.org/article/c7f855dc19a44fd2a9928f021838f263
Autor:
Tomas Kouba, Dominik Vogel, Sigurdur R. Thorkelsson, Emmanuelle R. J. Quemin, Harry M. Williams, Morlin Milewski, Carola Busch, Stephan Günther, Kay Grünewald, Maria Rosenthal, Stephen Cusack
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The L protein of segmented, negative strand RNA viruses contains the RNA-dependent RNA polymerase essential for virus amplification. Here, the authors report cryoEM structures of the Lassa virus L protein in active, RNA-bound states, and provide mech
Externí odkaz:
https://doaj.org/article/97a04e7215a44a4ebaec52c71bff412e
Autor:
Tim Krischuns, Catherine Isel, Petra Drncova, Maria Lukarska, Alexander Pflug, Sylvain Paisant, Vincent Navratil, Stephen Cusack, Nadia Naffakh
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010328 (2022)
During annual influenza epidemics, influenza B viruses (IBVs) co-circulate with influenza A viruses (IAVs), can become predominant and cause severe morbidity and mortality. Phylogenetic analyses suggest that IAVs (primarily avian viruses) and IBVs (p
Externí odkaz:
https://doaj.org/article/cde8c4d7d9d74d3b849516543866cee9