Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Stephen Craig Weldon"'
Autor:
John Trauger, Susan Hanrahan, Kevin Godbout, Fangmin Xu, Amitabh V. Nimonkar, Rose Cubbon, Andrei Igorevich Voznesensky, Jiaping Gao, Stephen Craig Weldon, Darrell Panza
Publikováno v:
The Journal of Biological Chemistry
Lipoprotein lipase (LPL) is central to triglyceride metabolism. Severely compromised LPL activity causes familial chylomicronemia syndrome (FCS), which is associated with very high plasma triglyceride levels and increased risk of life-threatening pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de259fa3fa14137c06b2f693fe82ea7
http://europepmc.org/articles/PMC7062184
http://europepmc.org/articles/PMC7062184
Autor:
Patricia A. Horton, Daniel Baird, Philipp Lehr, Amitabh V. Nimonkar, Rose Cubbon, Flyer Alec, Timothy E. Benson, Peter Meier, Chun-Hao Chiu, John Trauger, William R. Tschantz, Chunhua Wang, Aleksandar Stojanovic, Thomas M. Smith, Rishi Arora, Stephen Craig Weldon, Pramod Pandey, Reto Brunner, Michael J. Romanowski, Susan Hanrahan, Andrei Igorevich Voznesensky, Sascha Mueller, Johannes Ottl
Lipoprotein lipase (LPL) plays a central role in triglyceride (TG) metabolism. By catalyzing the hydrolysis of TGs present in TG-rich lipoproteins (TRLs), LPL facilitates TG utilization and regulates circulating TG and TRL concentrations. Until very
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53ee6ab3c252db213aa83a6100d0fcf
https://europepmc.org/articles/PMC6534989/
https://europepmc.org/articles/PMC6534989/
Autor:
Virendar K. Kaushik, Michael Kavana, Stephen Craig Weldon, Jessica M. Volz, Shari L. Caplan, Jian Xu, Brian K. Hubbard, Susan Hanrahan
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1794:961-967
Acetyl-CoA carboxylase (ACC) catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA, a key metabolite in the fatty acid synthetic and oxidation pathways. The present study describes the steady-state kinetic analysis of a purified recombinant h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be429714a45dad8d3487da08241b37e8
https://doi.org/10.1016/j.bbapap.2009.02.004
https://doi.org/10.1016/j.bbapap.2009.02.004
Autor:
Geesje H. Kiers, Johan M. TeKoppele, Jessica V. Valencia, Thomas Edward Hughes, Jeroen DeGroot, Stephen Craig Weldon, Douglas Frederick Quinn
Publikováno v:
Analytical Biochemistry. 324:68-78
Advanced glycation end products (AGEs) accumulate with age and at an accelerated rate in diabetes. AGEs bind cell-surface receptors including the receptor for advanced glycation end products (RAGE). The dependence of RAGE binding on specific biochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9201653dbd373ed33a4ed4f9a381d9e7
https://doi.org/10.1016/j.ab.2003.09.013
https://doi.org/10.1016/j.ab.2003.09.013
Autor:
Edwin Bernard Villhauer, Thomas Edward Hughes, John A Brinkman, Manisha Mone, Bonnie L Mangold, Mary E Russell, Goli B Naderi, Stephen Craig Weldon, Beth E. Dunning
Publikováno v:
Journal of Medicinal Chemistry. 45:2362-2365
Dipeptidyl peptidase IV (DPP-IV) inhibition has the potential to become a valuable therapy for type 2 diabetes. We report the first use of solid-phase synthesis in the discovery of a new DPP-IV inhibitor class and a solution-phase synthesis that is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a23159d1dca769374d0d90eb53fdcb
https://doi.org/10.1021/jm025522z
https://doi.org/10.1021/jm025522z
Autor:
Mary E Russell, Thomas Edward Hughes, Stephen Craig Weldon, Manisha Mone, Edwin Bernard Villhauer
Publikováno v:
Biochemistry. 38:11597-11603
Inhibition of dipeptidyl peptidase IV (DPP-IV) has been proposed recently as a therapeutic approach to the treatment of type 2 diabetes. N-Substituted-glycyl-2-cyanopyrrolidide compounds, typified by NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]eth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29998feb3ce0dfbc1ddd410083a4758
https://doi.org/10.1021/bi990852f
https://doi.org/10.1021/bi990852f