Zobrazeno 1 - 10
of 677
pro vyhledávání: '"Stephen Clarke"'
Autor:
Lavinia Tan, Chris Brown, Antony Mersiades, Chee Khoon Lee, Thomas John, Steven Kao, Genni Newnham, Kenneth O’Byrne, Sagun Parakh, Victoria Bray, Kevin Jasas, Sonia Yip, Stephen Q. Wong, Sarah Ftouni, Jerick Guinto, Sushma Chandrashekar, Stephen Clarke, Nick Pavlakis, Martin R. Stockler, Sarah-Jane Dawson, Benjamin J. Solomon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract In this phase II, single arm trial (ACTRN12617000720314), we investigate if alternating osimertinib and gefitinib would delay the development of resistance to osimertinib in advanced, non-small cell lung cancer (NSCLC) with the epidermal gro
Externí odkaz:
https://doaj.org/article/2aee772d175142968edb2117d86331be
Autor:
Quincy Chu, MD, Natasha B. Leighl, MD, Veerle Surmont, MD, Carla van Herpen, MD, PhD, Anne Sibille, MD, Ben Markman, MD, Stephen Clarke, MD, Rosalyn A. Juergens, MD, PhD, Mirelis Acosta Rivera, MD, Vladimir Andelkovic, MD, Charles M. Rudin, MD, PhD, Stephanie Snow, MD, Dong-Wan Kim, MD, Michael Sanatani, MD, Hongxia Lin, PhD, Kinjal Sanghavi, PhD, Sarah Tannenbaum-Dvir, MD, Paul Basciano, MD, Deanne Lathers, PhD, Katarzyna Urbanska, PhD, Georgia Kollia, PhD, Chunsheng He, PhD, Andrew DiPiero, BS, Yu Liu, MD, PhD, Neal Ready, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 3, Iss 11, Pp 100400- (2022)
Introduction: Fucosyl-GM1 is a monosialoganglioside with limited expression in healthy tissues and high expression on SCLC cells. BMS-986012 is a nonfucosylated, first-in-class, fully human immunoglobulin G1 monoclonal antibody that binds to fucosyl-
Externí odkaz:
https://doaj.org/article/f5bd2944b1a6435ab4a355125a671725
Autor:
Tamkin Ahmadzada, Abhishek Vijayan, Fatemeh Vafaee, Ali Azimi, Glen Reid, Stephen Clarke, Steven Kao, Georges E. Grau, Elham Hosseini-Beheshti
Publikováno v:
Cancers, Vol 15, Iss 8, p 2364 (2023)
Pleural mesothelioma, previously known as malignant pleural mesothelioma, is an aggressive and fatal cancer of the pleura, with one of the poorest survival rates. Pleural mesothelioma is in urgent clinical need for biomarkers to aid early diagnosis,
Externí odkaz:
https://doaj.org/article/14b092f768364a40a67477debe87215d
Autor:
Stephen Clarke, Belinda E. Butcher, Andrew J. McLachlan, Jeremy D. Henson, David Rutolo, Sean Hall, Luis Vitetta
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
This pilot study aimed to assess the safety, tolerability, pharmacokinetics and exploratory analgesic effect of a novel water-soluble oro-buccal nanoparticle spray of a cannabis-based medicine (MDCNS-01) in patients with advanced incurable malignancy
Externí odkaz:
https://doaj.org/article/8094411824f5485a85eca9f1eb59965e
Autor:
Byeongsang Oh, Frances Boyle, Nick Pavlakis, Stephen Clarke, Alex Guminski, Thomas Eade, Gillian Lamoury, Susan Carroll, Marita Morgia, Andrew Kneebone, George Hruby, Mark Stevens, Wen Liu, Brian Corless, Mark Molloy, Towia Libermann, David Rosenthal, Michael Back
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Increasing evidence suggests that the gut microbiome is associated with both cancer chemotherapy (CTX) outcomes and adverse events (AEs). This review examines the relationship between the gut microbiome and CTX as well as the impact of CTX on the gut
Externí odkaz:
https://doaj.org/article/55fe88a7821b4413912e926930a2d51c
Publikováno v:
Chemical Thermodynamics and Thermal Analysis, Vol 3, Iss , Pp 100014- (2021)
Moving into a carbon constrained world it is imperative that new forms of energy generation and storage are implemented to replace the fossil-fuel driven economy. Additionally, this dependence on fossil-fuels has generated large amounts of waste mate
Externí odkaz:
https://doaj.org/article/ee956a1a87074a2a90638ad4be30f62a
Autor:
Oliver Illini, Maximilian Johannes Hochmair, Hannah Fabikan, Christoph Weinlinger, Amanda Tufman, Aurélie Swalduz, Kristina Lamberg, Sayed M. S. Hashemi, Florian Huemer, Anders Vikström, Martin Wermke, Gudrun Absenger, Alfredo Addeo, Shantanu Banerji, Antonio Calles, Stephen Clarke, Massimo Di Maio, Alice Durand, Michaël Duruisseaux, Malinda Itchins, Okko-Sakari Kääränien, Florian Krenn, Eckart Laack, Adrianus Johannes de Langen, Katja Mohorcic, Georg Pall, Antonio Passaro, Gerald Prager, Achim Rittmeyer, Jeffrey Rothenstein, Michael Schumacher, Ewald Wöll, Arschang Valipour
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Introduction: Rearranged during transfection (RET) gene fusions are rare genetic drivers in non-small cell lung cancer (NSCLC). Selective RET-inhibitors such as selpercatinib have shown therapeutic activity in early clinical trials; however, their ef
Externí odkaz:
https://doaj.org/article/fa3f18a7c5a247f2bb673138b510d84e
Autor:
Christopher B. Nahm, John Turchini, Sumit Sahni, Elizabeth Moon, Malinda Itchins, Jennifer Arena, Angela Chou, Emily K. Colvin, Viive M. Howell, Nick Pavlakis, Stephen Clarke, Jaswinder S. Samra, Anthony J. Gill, Anubhav Mittal
Publikováno v:
Cancers, Vol 14, Iss 15, p 3620 (2022)
The genomic heterogeneity of pancreatic ductal adenocarcinoma (PDAC) is becoming increasingly appreciated. We aimed to evaluate the ability of a triple biomarker panel (S100A4, Ca-125, and mesothelin) to predict: (i) genetic PDAC subtypes; (ii) clini
Externí odkaz:
https://doaj.org/article/a7487d323c4747c5b02d312669b554df
Autor:
Tamkin Ahmadzada, BE, Wendy A. Cooper, BScMed, M.B.B.S., PhD, FRCPA, Mikaela Holmes, BBiomedSc, Annabelle Mahar, M.B.B.S., FRCPA, Helen Westman, MPH, Anthony J. Gill, MD, FRCPA, Ina Nordman, M.B.B.S., FRACP, M(Med)Sc, Po Yee Yip, MbChB., FRACP, PhD, Abhijit Pal, BSc (Hons), M.B.B.S., FRACP, Rob Zielinski, FRACP, M.B.B.S., Hons, Nick Pavlakis, BSc, M.B.B.S., MMed (Clin Epi), PhD, FRACP, Adnan Nagrial, M.B.B.S., PhD, Dariush Daneshvar, MD, FRCPA, Daniel Brungs, M.B.B.S., MMed (Clin Epi), FRCPA, Deme Karikios, BSc, M.B.B.S., FRACP, PhD, Vesna Aleksova, BMedSc, Juliet Burn, M.B.B.S., FRCPA, MIAC, Rebecca Asher, MSc, Georges E. Grau, MD, PhD, Elham Hosseini-Beheshti, MSc, PhD, Glen Reid, PhD, Stephen Clarke, MD, PhD, FRACP, Steven Kao, BHB, MbChB., PhD, FRACP
Publikováno v:
JTO Clinical and Research Reports, Vol 1, Iss 4, Pp 100075- (2020)
Introduction: We investigated the efficacy and toxicity of pembrolizumab in patients with mesothelioma from a real-world Australian population. We aimed to determine clinical factors and predictive biomarkers that could help select patients who are l
Externí odkaz:
https://doaj.org/article/8decaaa69f954183bf0aaa4a972c4d8b
Autor:
Andrew Jang BHSc, Chris Brown MBiostat, Gillian Lamoury MBBS, Marita Morgia MBBS, Frances Boyle MBBS, PhD, Isobel Marr MD, Stephen Clarke MBBS, PhD, Michael Back MBBS, PhD, Byeongsang Oh Oh, PhD
Publikováno v:
Integrative Cancer Therapies, Vol 19 (2020)
Background Several studies have identified fatigue as one of the major symptoms experienced during and after cancer treatment. However, there are limited options to manage cancer related fatigue (CRF) with pharmacological interventions. Several acupu
Externí odkaz:
https://doaj.org/article/7c2e97e838a3412fa820b3f3c559786b