Zobrazeno 1 - 10
of 579
pro vyhledávání: '"Stephen C. Woods"'
Autor:
Tim Gruber, Franziska Lechner, Cahuê Murat, Raian E. Contreras, Eva Sanchez-Quant, Viktorian Miok, Konstantinos Makris, Ophélia Le Thuc, Ismael González-García, Elena García-Clave, Ferdinand Althammer, Quirin Krabichler, Lisa M. DeCamp, Russell G. Jones, Dominik Lutter, Rhiannan H. Williams, Paul T. Pfluger, Timo D. Müller, Stephen C. Woods, John Andrew Pospisilik, Celia P. Martinez-Jimenez, Matthias H. Tschöp, Valery Grinevich, Cristina García-Cáceres
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113305- (2023)
Summary: Oxytocin-expressing paraventricular hypothalamic neurons (PVNOT neurons) integrate afferent signals from the gut, including cholecystokinin (CCK), to adjust whole-body energy homeostasis. However, the molecular underpinnings by which PVNOT n
Externí odkaz:
https://doaj.org/article/90782dfc60ca478ea59744d818a5084b
Autor:
Ruth Gutierrez-Aguilar, Bernadette E. Grayson, Dong-Hoon Kim, Suma Yalamanchili, Mario L. Calcagno, Stephen C. Woods, Randy J. Seeley
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
GNPDA2 has been associated with human obesity and type-2 diabetes by using a GWAS approach. GNPDA2 is an enzyme involved in the hexosamine biosynthesis pathway, which is known to be important for nutrient sensing in various organism. Its counter enzy
Externí odkaz:
https://doaj.org/article/929cf6355a8040a892243288d86fea76
Autor:
Katrin Fischer, Anna Fenzl, Dianxin Liu, Kenneth A. Dyar, Maximilian Kleinert, Markus Brielmeier, Christoffer Clemmensen, Anna Fedl, Brian Finan, Andre Gessner, Martin Jastroch, Jianfeng Huang, Susanne Keipert, Martin Klingenspor, Jens C. Brüning, Manfred Kneilling, Florian C. Maier, Ahmed E. Othman, Bernd J. Pichler, Ines Pramme-Steinwachs, Stephan Sachs, Angelika Scheideler, Wolfgang M. Thaiss, Henriette Uhlenhaut, Siegfried Ussar, Stephen C. Woods, Julia Zorn, Kerstin Stemmer, Sheila Collins, Maria Diaz-Meco, Jorge Moscat, Matthias H. Tschöp, Timo D. Müller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Beta-adrenergic stimulation of brown adipose tissue leads to thermogenesis via the activating transcription factor 2 (ATF2) mediated expression of the thermogenic genes Ucp1 and Pgc-1α. Here, the authors show that the scaffold protein p62 regulates
Externí odkaz:
https://doaj.org/article/f38460b423054ee680f7224c62a860c9
Autor:
Caitlin S. Mitchell, Shirmila D. Premaratna, Garth Bennett, Maria Lambrou, Lauren A. Stahl, Markandeya Jois, Elizabeth Barber, Christopher P. Antoniadis, Stephen C. Woods, David Cameron-Smith, Richard S. Weisinger, Denovan P. Begg
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Obesity is a growing health problem worldwide. The renin-angiotensin system (RAS) is present in adipose tissue, and evidence suggests that it is involved in both diet-induced obesity and the inflammation associated with obesity. The present experimen
Externí odkaz:
https://doaj.org/article/58d2e06465f549929fd5e35e4c5d2651
Autor:
Anna Götz, Maarit Lehti, Elizabeth Donelan, Cynthia Striese, Sebastian Cucuruz, Stephan Sachs, Chun-Xia Yi, Stephen C. Woods, Samuel D. Wright, Timo D. Müller, Matthias H. Tschöp, Yuanqing Gao, Susanna M. Hofmann
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1649-1659 (2018)
Meta-inflammation of hypothalamic areas governing energy homeostasis has recently emerged as a process of potential pathophysiological relevance for the development of obesity and its metabolic sequelae. The current model suggests that diet-induced n
Externí odkaz:
https://doaj.org/article/e48b521b49e04043b963b66df01ecbce
Autor:
Yuanqing Gao, Maximilian Bielohuby, Thomas Fleming, Gernot F. Grabner, Ewout Foppen, Wagner Bernhard, Mara Guzmán-Ruiz, Clarita Layritz, Beata Legutko, Erwin Zinser, Cristina García-Cáceres, Ruud M. Buijs, Stephen C. Woods, Andries Kalsbeek, Randy J. Seeley, Peter P. Nawroth, Martin Bidlingmaier, Matthias H. Tschöp, Chun-Xia Yi
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 897-908 (2017)
Objective: The hypothalamus of hypercaloric diet-induced obese animals is featured by a significant increase of microglial reactivity and its associated cytokine production. However, the role of dietary components, in particular fat and carbohydrate,
Externí odkaz:
https://doaj.org/article/f5b9d5091cac4e21b7d0d5e9cc05918d
Autor:
Chun-Xia Yi, Marc Walter, Yuanqing Gao, Soledad Pitra, Beata Legutko, Stefanie Kälin, Clarita Layritz, Cristina García-Cáceres, Maximilian Bielohuby, Martin Bidlingmaier, Stephen C. Woods, Alexander Ghanem, Karl-Klaus Conzelmann, Javier E. Stern, Martin Jastroch, Matthias H. Tschöp
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Long-term consumption of a calorie-rich diet persistently activates brain microglia. Here, the authors show that microglial activity in mouse brains oscillates daily in conjunction with feeding, and that TNFα, secreted by activated microglia, induce
Externí odkaz:
https://doaj.org/article/6cf55e31e14747279bd3ace341933215
Autor:
Jenna Holland, Joyce Sorrell, Emily Yates, Kathleen Smith, Shahriar Arbabi, Myrtha Arnold, Marita Rivir, Rachel Morano, Jenny Chen, Xiang Zhang, Richard Dimarchi, Stephen C. Woods, Joan Sanchez-Gurmaches, Eric Wohleb, Diego Perez-Tilve
Publikováno v:
Cell Reports, Vol 27, Iss 8, Pp 2399-2410.e6 (2019)
Summary: The melanocortin system is a brain circuit that influences energy balance by regulating energy intake and expenditure. In addition, the brain-melanocortin system controls adipose tissue metabolism to optimize fuel mobilization and storage. S
Externí odkaz:
https://doaj.org/article/37f4fedec4f1438888426dda4e132b9a
Autor:
Dhiraj G. Kabra, Katrin Pfuhlmann, Cristina García-Cáceres, Sonja C. Schriever, Veronica Casquero García, Adam Fiseha Kebede, Esther Fuente-Martin, Chitrang Trivedi, Kristy Heppner, N. Henriette Uhlenhaut, Beata Legutko, Uma D. Kabra, Yuanqing Gao, Chun-Xia Yi, Carmelo Quarta, Christoffer Clemmensen, Brian Finan, Timo D. Müller, Carola W. Meyer, Marcelo Paez-Pereda, Kerstin Stemmer, Stephen C. Woods, Diego Perez-Tilve, Robert Schneider, Eric N. Olson, Matthias H. Tschöp, Paul T. Pfluger
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDA
Externí odkaz:
https://doaj.org/article/05d180e6a43443a4a0aaf1a16b919fe2
Autor:
Silvana Obici, I. Jack Magrisso, Armen S. Ghazarian, Alireza Shirazian, Jonas R. Miller, Christine M. Loyd, Denovan P. Begg, Kimberly A. Krawczewski Carhuatanta, Michael K. Haas, Jon F. Davis, Stephen C. Woods, Darleen A. Sandoval, Randy J. Seeley, Laurie J. Goodyear, Emmanuel N. Pothos, Joram D. Mul
Publikováno v:
Molecular Metabolism, Vol 4, Iss 10, Pp 692-705 (2015)
Objective: Melanocortin-4 receptors (MC4Rs) are highly expressed by dopamine-secreting neurons of the mesolimbic tract, but their functional role has not been fully resolved. Voluntary wheel running (VWR) induces adaptations in the mesolimbic dopamin
Externí odkaz:
https://doaj.org/article/4c660839e71d4506b3fc5729cebc1ffc