Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Stephen C. Tovey"'
Autor:
Nagendra Babu Thillaiappan, Alap P. Chavda, Stephen C. Tovey, David L. Prole, Colin W. Taylor
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
IP3 receptors mediate Ca2+ release from the endoplasmic reticulum. Here the authors show that only a small fraction of IP3 receptors initiate Ca2+ signals; these immobile IP3 receptors adjacent to the plasma membrane are optimally placed to control S
Externí odkaz:
https://doaj.org/article/ccb66cca43dc44d68437d57d5d389ef9
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 711-722 (2017)
Inositol 1,4,5-trisphosphate (IP3) stimulates Ca2+ release from the endoplasmic reticulum (ER), and the response is potentiated by 3′,5′-cyclic AMP (cAMP). We investigated this interaction in HEK293 cells using carbachol and parathyroid hormone (
Externí odkaz:
https://doaj.org/article/38690534bf704f8d986712600f27467e
Publikováno v:
Saleem, H, Tovey, S C, Riley, A M, Potter, B V L & Taylor, C W 2013, ' Stimulation of inositol 1,4,5-trisphosphate (IP 3 ) receptor subtypes by Adenophostin A and its analogues ', PLoS ONE, vol. 8, no. 2, e58027 . https://doi.org/10.1371/journal.pone.0058027
PLoS ONE
PLoS ONE, Vol 8, Iss 2, p e58027 (2013)
PLoS ONE
PLoS ONE, Vol 8, Iss 2, p e58027 (2013)
Inositol 1,4,5-trisphosphate receptors (IP3R) are intracellular Ca2+ channels. Most animal cells express mixtures of the three IP3R subtypes encoded by vertebrate genomes. Adenophostin A (AdA) is the most potent naturally occurring agonist of IP3R an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e433b9aa8e6d501ffe5ba1325f1cc3a9
https://doi.org/10.1371/journal.pone.0058027
https://doi.org/10.1371/journal.pone.0058027
Publikováno v:
Journal of Cell Science. 126:289-300
Summary Most intracellular Ca2+ signals result from opening of Ca2+ channels in the plasma membrane or endoplasmic reticulum (ER), and they are reversed by active transport across these membranes or by shuttling Ca2+ into mitochondria. Ca2+ channels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4204ab38b5bc9d5e88aebca7daa84fdd
https://doi.org/10.1242/jcs.116103
https://doi.org/10.1242/jcs.116103
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1820:1214-1227
Background Inositol 1,4,5-trisphosphate receptors (IP 3 R) are expressed in almost all animal cells. Three mammalian genes encode closely related IP 3 R subunits, which assemble into homo- or hetero-tetramers to form intracellular Ca 2 + channels. Sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db58e633a8d3fb46762594e8e4675492
https://doi.org/10.1016/j.bbagen.2011.10.004
https://doi.org/10.1016/j.bbagen.2011.10.004
Autor:
Mark P. Thomas, Colin W. Taylor, Andrew M. Riley, Barry V. L. Potter, Stephen C. Tovey, Kana M. Sureshan
Publikováno v:
Journal of Medicinal Chemistry
Although adenophostin A (AdA), the most potent agonist of d-myo-inositol 1,4,5-trisphosphate receptors (IP(3)R), is thought to mimic IP(3), the relative roles of the different phosphate groups and the adenosine motif have not been established. We syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7c3e552fcbe2034a03072f106c5881
https://doi.org/10.1021/jm201571p
https://doi.org/10.1021/jm201571p
Autor:
Colin W. Taylor, Stephen C. Tovey
Publikováno v:
Biochemical Society Transactions. 40:147-152
PTHR1 (type 1 parathyroid hormone receptors) mediate the effects of PTH (parathyroid hormone) on bone remodelling and plasma Ca 2+ homoeostasis. PTH, via PTHR1, can stimulate both AC (adenylate cyclase) and increases in [Ca 2+ ] i (cytosolic free Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2a20346ed8df3a72fcdc40ede92ba9
https://doi.org/10.1042/bst20110615
https://doi.org/10.1042/bst20110615
Publikováno v:
European Journal of Pharmacology. 587:16-24
Termination of signalling by G-protein-coupled receptors requires inactivation of the G alpha-subunits of heterotrimeric G-proteins and the re-association of G alpha- and G betagamma-subunits. Inactivation of G alpha-subunits is achieved by the hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b17595cb8830cdfb1f95839d28d1f6
https://doi.org/10.1016/j.ejphar.2008.03.047
https://doi.org/10.1016/j.ejphar.2008.03.047
Autor:
Heinrich Sauer, Maria Wartenberg, Helmut Kettenmann, Stephen C. Tovey, Martin Falcke, Ulrike Winkler, Alexander Skupin, Colin W. Taylor
Publikováno v:
Biophysical Journal. 94(6):2404-2411
Ca2+ oscillations have been considered to obey deterministic dynamics for almost two decades. We show for four cell types that Ca2+ oscillations are instead a sequence of random spikes. The standard deviation of the interspike intervals (ISIs) of ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42e3bdf6bb0be5088329d829f924ca9
Publikováno v:
The Journal of Organic Chemistry. 73:1682-1692
Adenophostin A (AdA) is a potent agonist of the d-myo-inositol 1,4,5-trisphosphate receptor (Ins(1,4,5)P3R). Various 2-aminopurine analogues of AdA were synthesized, all of which (guanophostin 5, 2,6-diaminopurinophostin 6, 2-aminopurinophostin 7, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c5e845c89f1830ce552b2a85569461
https://doi.org/10.1021/jo702617c
https://doi.org/10.1021/jo702617c