Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Stephen C. DeRosa"'
Autor:
Catherine A Cosgrove, Charles J Lacey, Alethea V Cope, Angela Bartolf, Georgina Morris, Celine Yan, Susan Baden, Tom Cole, Darrick Carter, Elizabeth Brodnicki, Xiaoying Shen, Sarah Joseph, Stephen C DeRosa, Lili Peng, Xuesong Yu, Guido Ferrari, Mike Seaman, David C Montefiori, Nicole Frahm, Georgia D Tomaras, Wolfgang Stöhr, Sheena McCormack, Robin J Shattock
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0152038 (2016)
BackgroundDefining optimal routes for induction of mucosal immunity represents an important research priority for the HIV-1 vaccine field. In particular, it remains unclear whether mucosal routes of immunization can improve mucosal immune responses.M
Externí odkaz:
https://doaj.org/article/08ec5605bc8444f7b1cb6ed38f6f0216
Autor:
Glenna J. Peterson, Chetan Seshadri, Raphael Gottardo, Thomas R. Hawn, David Freidrich, Stephen C. DeRosa, Greg Finak, Jacques Prandi, Martine Gilleron, D. Branch Moody, M. Juliana McElrath, Hassan Mahomed, Nicole Frahm, Willem A. Hanekom, Wenxin Jiang, Thomas J. Scriba, Lin Lin
Publikováno v:
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2015, 195 (10), pp.4595-4603. ⟨10.4049/jimmunol.1501285⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2015, 195 (10), pp.4595-4603. ⟨10.4049/jimmunol.1501285⟩
Human T cells are activated by both peptide and nonpeptide Ags produced by Mycobacterium tuberculosis. T cells recognize cell wall lipids bound to CD1 molecules, but effector functions of CD1-reactive T cells have not been systematically assessed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3657ec2e6532eff746f2e8d59a748ed4
https://doi.org/10.4049/jimmunol.1501285
https://doi.org/10.4049/jimmunol.1501285
Autor:
Harlan Robins, Stephen C. DeRosa, Chetan Seshadri, Cheryl L. Day, Damien B. Wilburn, Marissa Vignali, Krystle K. Quan, Thomas J. Scriba, Willie J. Swanson, Ryan O. Emerson, William S DeWitt, Anna Sherwood
Peptide-specific T cells that are restricted by highly polymorphic major histocompatibility complex (MHC) proteins express diverse T-cell receptors (TCRs) that are rarely shared among unrelated individuals. T-cells can also recognize bacterial lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113554cf6bbfaf8ce7cbe249d45408e4
https://doi.org/10.1101/123174
https://doi.org/10.1101/123174
Autor:
Stephen C. DeRosa, Alicia Sato, Lindsey R. Baden, Georgia D. Tomaras, Paul A. Goepfert, Olivier D. Defawe, Marnie Elizaga, Linda S. Wyatt, Lilin Lai, William A. Blattner, Sharon E. Frey, Bernard Moss, Harriet L. Robinson, Massimo Cardinali, Li Qin, David C. Montefiori, Christine M. Hay, Spyros A. Kalams, Yongxian Xu, John Hural
Publikováno v:
The Journal of Infectious Diseases. 203:610-619
Background. Recombinant DNA and modified vaccinia virus Ankara (rMVA) vaccines represent a promising approach to an HIV/AIDS vaccine. This Phase 1 clinical trial compared the safety and immunogenicity of a rMVA vaccine administered with and without D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87eb69c2aa1d56815a72d3ad681aebc3
https://doi.org/10.1093/infdis/jiq105
https://doi.org/10.1093/infdis/jiq105
Autor:
James I. Mullins, Ann E. Woolfrey, Angela D. M. Kashuba, Andrea C. Repetto, Christopher W. Peterson, Stephen C. DeRosa, Kevin G. Haworth, Hans-Peter Kiem, Willimark M. Obenza, Shiu Lok Hu, Craig Sykes, Keith R. Jerome, Meei Li Huang, Patricia Polacino, Roger E. Bumgarner
Publikováno v:
AIDS (London, England). 29(13)
Objective We have previously demonstrated robust control of simian/human immunodeficiency virus (SHIV1157-ipd3N4) viremia following administration of combination antiretroviral therapy (cART) in pigtailed macaques. Here, we sought to determine the sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681fa17c4dba112f21ce2de687217868
https://pubmed.ncbi.nlm.nih.gov/26372270
https://pubmed.ncbi.nlm.nih.gov/26372270
Autor:
Stephen C. DeRosa, Xuesong Yu, Xia Jin, David C. Montefiori, James G. Kublin, Lawrence Corey, Michael C. Keefer, Georgia D. Tomaras, Cecilia Morgan
Publikováno v:
Vaccine. 33(20)
Plasmid DNA vaccines have been licensed for use in domesticated animals because of their excellent immunogenicity, but none have yet been licensed for use in humans. Here we report a retrospective analysis of 1218 healthy human volunteers enrolled in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a68bea8b36b18d36bf4e86ecd05c288
https://pubmed.ncbi.nlm.nih.gov/25820067
https://pubmed.ncbi.nlm.nih.gov/25820067
Autor:
Paul A, Goepfert, Marnie L, Elizaga, Kelly, Seaton, Georgia D, Tomaras, David C, Montefiori, Alicia, Sato, John, Hural, Stephen C, DeRosa, Spyros A, Kalams, M Juliana, McElrath, Michael C, Keefer, Lindsey R, Baden, Javier R, Lama, Jorge, Sanchez, Mark J, Mulligan, Susan P, Buchbinder, Scott M, Hammer, Beryl A, Koblin, Michael, Pensiero, Chris, Butler, Bernard, Moss, Harriet L, Robinson, Jennifer, Johnson
Publikováno v:
The Journal of infectious diseases. 210(1)
A human immunodeficiency virus (HIV) vaccine faces the challenge of eliciting immune responses that can prevent the acquisition of virus and the establishment of latency. Vaccine-induced antibodies (Abs) can block infection by directly neutralizing v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa8f5058fee7958b485f9018ac63c21
https://pubmed.ncbi.nlm.nih.gov/24403557
https://pubmed.ncbi.nlm.nih.gov/24403557
Autor:
Lindsey R. Baden, Kelly E. Seaton, Alicia Sato, Georgia D. Tomaras, Laissa Ouedraogo, Paul A. Goepfert, Marnie Elizaga, Stephen C. DeRosa, J. McElrath, Harriet L. Robinson, Javier R. Lama, Massimo Cardinali, David C. Montefiori, John Hural, Michael C. Keefer, Spyros A. Kalams, Y Donastorg
Publikováno v:
Retrovirology, Vol 9, Iss Suppl 2, p O56 (2012)
Retrovirology
Retrovirology
Methods 150 vaccinia-naive participants were inoculated i.m. via needle and syringe with 3 mg of pGA2/JS7 DNA at months 0 and 2, and 1x108 TCID50 of MVA/HIV62B at months 4 and 6 (DDMM regimen). 75 participants received 1x108 TCID50 of MVA/HIV62B at m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd26736dfdaea85f8c55de5113b2826
https://doi.org/10.1186/1742-4690-9-s2-o56
https://doi.org/10.1186/1742-4690-9-s2-o56
Autor:
Xia Jin, Elizabeth A. Noonan, Evan P. Thomas, Margaret Wecker, William A. Blattner, Denise M. McKinney, Olivier D. Defawe, Mark Newman, Jonathan D. Fuchs, Cristine Cooper, Allan C. deCamp, Brian D. Livingston, Stephen C. DeRosa, Michael C. Keefer
A Phase I human vaccine trial of a novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was conducted in 84 healthy adult volunteers. The vaccine immunogenicity was assessed by an intracellular cytokine s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d5eeddbabc1ba3eaa4fdd430974e86
https://europepmc.org/articles/PMC2784203/
https://europepmc.org/articles/PMC2784203/
Autor:
Stephen C. DeRosa, Maphoshane Nchabeleng, Glenda Gray, Gavin J. Churchyard, Kennedy Otwombe, Kathryn L. Hopkins, James G. Kublin, Linda-Gail Bekker, Fatima Laher, Koleka Mlisana
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 8, p e103446 (2014)
PLoS One
PLoS ONE, Vol 9, Iss 8, p e103446 (2014)
PLoS One
Background Phambili, the Merck (MRK)-Adenovirus Type 5 (Ad5) HIV-1 gag/pol/nef subtype B vaccine study, conducted in South Africa, suspended enrollment and vaccination when companion study, Step, was found non-efficacious. Although the vaccine did no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d0338b3f185bf14eecc05c39c5113e
https://doi.org/10.1371/journal.pone.0103446
https://doi.org/10.1371/journal.pone.0103446