Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Stephen C. Bunnell"'
Autor:
Giang T. Nguyen, Shuying Xu, Walter Adams, John M. Leong, Stephen C. Bunnell, Michael K. Mansour, David B. Sykes, Joan Mecsas
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102871- (2021)
Summary: Signaling cascades converting the recognition of pathogens to efficient inflammatory responses by neutrophils are critical for host survival. SKAP2, an adaptor protein, is required for reactive oxygen species (ROS) generation following neutr
Externí odkaz:
https://doaj.org/article/59195d184ccc476c954222112e115428
Autor:
Parisa Kalantari, Yoelkys Morales, Emily A. Miller, Luis D. Jaramillo, Holly E. Ponichtera, Marcel A. Wuethrich, Cheolho Cheong, Maria C. Seminario, Joanne M. Russo, Stephen C. Bunnell, Miguel J. Stadecker
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1288-1300 (2018)
Summary: The immunopathology caused by schistosome helminths varies greatly in humans and among mouse strains. A severe form of parasite egg-induced hepatic granulomatous inflammation, seen in CBA mice, is driven by Th17 cells stimulated by IL-1β an
Externí odkaz:
https://doaj.org/article/278196c7e2b341c291f80d933d3d0e25
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Schistosomiasis is a major helminthic disease in which damage to the affected organs is orchestrated by a pathogenic host CD4 T helper (Th) cell-mediated immune response against parasite eggs. In the case of the species Schistosoma mansoni, the resul
Externí odkaz:
https://doaj.org/article/a108ae42f0384972b02016ee4437794d
Autor:
Giang T Nguyen, Lamyaa Shaban, Matthias Mack, Kenneth D Swanson, Stephen C Bunnell, David B Sykes, Joan Mecsas
Publikováno v:
eLife, Vol 9 (2020)
Klebsiella pneumoniae is a respiratory, blood, liver, and bladder pathogen of significant clinical concern. We show that the adaptor protein, SKAP2, is required for protection against K. pneumoniae (ATCC 43816) pulmonary infections. Skap2-/- mice had
Externí odkaz:
https://doaj.org/article/e5b85fc244194d89a9dbc2b9e48796d9
Autor:
Stephen C. Bunnell, Keith P. Eidell, Alenka Lovy, Ken Nguyen, Frank A Scangarello, Michael J. Ophir, Maria-Cristina Seminario, Hayley I. Muendlein, Nicholas R. Sylvain
Publikováno v:
J Cell Sci
Integrin engagement within the immune synapse enhances T cell activation, but our understanding of this process is incomplete. In response to T cell receptor (TCR) ligation, SLP-76 (LCP2), ADAP (FYB1) and SKAP55 (SKAP1) are recruited into microcluste
Autor:
Walter Adams, Michael K. Mansour, Joan Mecsas, Stephen C. Bunnell, Giang T. Nguyen, Shuying Xu, John M. Leong, David B. Sykes
Publikováno v:
iScience
iScience, Vol 24, Iss 8, Pp 102871-(2021)
iScience, Vol 24, Iss 8, Pp 102871-(2021)
Summary Signaling cascades converting the recognition of pathogens to efficient inflammatory responses by neutrophils are critical for host survival. SKAP2, an adaptor protein, is required for reactive oxygen species (ROS) generation following neutro
Autor:
Joan Mecsas, David B. Sykes, Shuying Xu, Michael K. Mansour, Giang T. Nguyen, Stephen C. Bunnell
Signaling cascades that convert the recognition of pathogens to efficient inflammatory responses by immune cells, specifically neutrophils, are critical for host survival. SKAP2, an adaptor protein, is required for reactive oxygen species (ROS) gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b1d785b4e86cc4531f5c146a9408fd9
https://doi.org/10.1101/2021.03.02.433609
https://doi.org/10.1101/2021.03.02.433609
Autor:
Nicholas R. Sylvain, Michael Fray, John C. Charpentier, Stephen C. Bunnell, Maria-Cristina Seminario
Publikováno v:
J Cell Sci
Vav family guanine nucleotide exchange factors (GEFs) are essential regulators of immune function. Despite their structural similarity, Vav1 promotes and Vav2 opposes T cell receptor (TCR)-induced Ca2+ entry. By using a Vav1-deficient Jurkat T cell l
Autor:
Jamie Heimburg-Molinaro, Maria A. DeCicco RePass, Honorine D. Ward, Najma Bhat, Stephen C. Bunnell, Richard D. Cummings
Publikováno v:
Molecular and Biochemical Parasitology. 221:56-65
Cryptosporidium spp. are the causative agents of diarrheal disease worldwide, but effective treatments are lacking. Cryptosporidium employs mucin-like glycoproteins with O-glycans to attach to and infect host intestinal epithelial cells. The Tn antig
Autor:
Andrea L. Szymczak-Workman, Joanne M. Murphy, Angela Montecalvo, Stephen C. Bunnell, Maria-Cristina Seminario, Lawrence P. Kane, Elizabeth A. DeRiso
The NF-κB essential modulator protein (NEMO) is required for activation of canonical NF-κB by the T cell antigen receptor (TCR). However, the subcellular localization of NEMO during this process is not well understood. By dynamically imaging fluore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28796826c73b9ffc3765392490d9896d
https://doi.org/10.1101/617126
https://doi.org/10.1101/617126