Zobrazeno 1 - 10
of 579
pro vyhledávání: '"Stephen C Woods"'
Autor:
Karin Meissner, Dominik Lutter, Christine von Toerne, Anja Haile, Stephen C Woods, Verena Hoffmann, Uli Ohmayer, Stefanie M Hauck, Matthias H Tschoep
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238533 (2020)
In this proof-of-concept study, we tested whether placebo effects can be monitored and predicted by plasma proteins. In a randomized controlled design, 90 participants were exposed to a nauseating stimulus on two separate days and were randomly alloc
Externí odkaz:
https://doaj.org/article/373772bd9de949b0abd9786652f04ad9
Autor:
Douglas S Ramsay, Salwa Al-Noori, Jason Shao, Brian G Leroux, Stephen C Woods, Karl J Kaiyala
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124740 (2015)
Considerable data suggest that individuals who appear minimally disrupted during an initial drug administration have elevated risk for abusing the drug later. A better understanding of this association could lead to more effective strategies for prev
Externí odkaz:
https://doaj.org/article/e011e13e17a54d63afcfe3a84f785954
Autor:
Darleen Sandoval, Jason G Barrera, Margaret A Stefater, Stephanie Sisley, Stephen C Woods, David D D'Alessio, Randy J Seeley
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51870 (2012)
GLP-1-induced insulin secretion from the β-cell is dependent upon glucose availability. The purpose of the current study was to determine whether CNS GLP-1 signaling is also glucose-dependent. We found that fasting blunted the ability of 3(rd) cereb
Externí odkaz:
https://doaj.org/article/af37cbba04ab4f748dfb86fa8a68f82c
Autor:
Samir Softic, Michelle Kirby, Nicholas G Berger, Noah F Shroyer, Stephen C Woods, Rohit Kohli
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38952 (2012)
Fatty liver disease (FLD) is commonly associated with insulin resistance and obesity, but interestingly it is also observed at low insulin states, such as prolonged fasting. Thus, we asked whether insulin is an independent modulator of hepatic lipid
Externí odkaz:
https://doaj.org/article/7653a6b461914f53b41df5b28e566048
Autor:
Yuanqing Gao, Maximilian Bielohuby, Thomas Fleming, Gernot F. Grabner, Ewout Foppen, Wagner Bernhard, Mara Guzmán-Ruiz, Clarita Layritz, Beata Legutko, Erwin Zinser, Cristina García-Cáceres, Ruud M. Buijs, Stephen C. Woods, Andries Kalsbeek, Randy J. Seeley, Peter P. Nawroth, Martin Bidlingmaier, Matthias H. Tschöp, Chun-Xia Yi
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 897-908 (2017)
Objective: The hypothalamus of hypercaloric diet-induced obese animals is featured by a significant increase of microglial reactivity and its associated cytokine production. However, the role of dietary components, in particular fat and carbohydrate,
Externí odkaz:
https://doaj.org/article/f5b9d5091cac4e21b7d0d5e9cc05918d
Autor:
Ismael González-García, Elena García-Clavé, Alberto Cebrian-Serrano, Ophélia Le Thuc, Raian E. Contreras, Yanjun Xu, Tim Gruber, Sonja C. Schriever, Beata Legutko, Jutta Lintelmann, Jerzy Adamski, Wolfgang Wurst, Timo D. Müller, Stephen C. Woods, Paul T. Pfluger, Matthias H. Tschöp, Alexandre Fisette, Cristina García-Cáceres
Publikováno v:
Cell metabolism 35(3), 438-455.e7 (2023). doi:10.1016/j.cmet.2023.02.004
Until menopause, women have a lower propensity to develop metabolic diseases than men, suggestive of a protective role for sex hormones. Although a functional synergy between central actions of estrogens and leptin has been demonstrated to protect ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea50ec13163a71892a9a6c287661c81
https://pub.dzne.de/record/256515
https://pub.dzne.de/record/256515
Autor:
Jens C. Brüning, Susanne Keipert, Bernd J. Pichler, Julia Zorn, Martin Klingenspor, Ines Pramme-Steinwachs, Siegfried Ussar, Martin Jastroch, Maria T. Diaz-Meco, Anna Fedl, Florian C. Maier, Markus Brielmeier, Jianfeng Huang, Stephan Sachs, Ahmed E. Othman, Henriette Uhlenhaut, Anna Fenzl, Jorge Moscat, M. H. Tschöp, Wolfgang M. Thaiss, Brian Finan, Maximilian Kleinert, Timo D. Müller, Kenneth A. Dyar, Manfred Kneilling, Stephen C. Woods, Angelika Scheideler, Dianxin Liu, Kerstin Stemmer, Christoffer Clemmensen, Katrin Fischer, Sheila Collins, André Gessner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nat. Commun. 11:2306 (2020)
Nature Communications
Fischer, K, Fenzl, A, Liu, D, Dyar, K A, Kleinert, M, Brielmeier, M, Clemmensen, C, Fedl, A, Finan, B, Gessner, A, Jastroch, M, Huang, J, Keipert, S, Klingenspor, M, Brüning, J C, Kneilling, M, Maier, F C, Othman, A E, Pichler, B J, Pramme-Steinwachs, I, Sachs, S, Scheideler, A, Thaiss, W M, Uhlenhaut, H, Ussar, S, Woods, S C, Zorn, J, Stemmer, K, Collins, S, Diaz-Meco, M, Moscat, J, Tschöp, M H & Müller, T D 2020, ' The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation ', Nature Communications, vol. 11, no. 1, 2306 . https://doi.org/10.1038/s41467-020-16230-8
Nat. Commun. 11:2306 (2020)
Nature Communications
Fischer, K, Fenzl, A, Liu, D, Dyar, K A, Kleinert, M, Brielmeier, M, Clemmensen, C, Fedl, A, Finan, B, Gessner, A, Jastroch, M, Huang, J, Keipert, S, Klingenspor, M, Brüning, J C, Kneilling, M, Maier, F C, Othman, A E, Pichler, B J, Pramme-Steinwachs, I, Sachs, S, Scheideler, A, Thaiss, W M, Uhlenhaut, H, Ussar, S, Woods, S C, Zorn, J, Stemmer, K, Collins, S, Diaz-Meco, M, Moscat, J, Tschöp, M H & Müller, T D 2020, ' The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation ', Nature Communications, vol. 11, no. 1, 2306 . https://doi.org/10.1038/s41467-020-16230-8
During β-adrenergic stimulation of brown adipose tissue (BAT), p38 phosphorylates the activating transcription factor 2 (ATF2) which then translocates to the nucleus to activate the expression of Ucp1 and Pgc-1α. The mechanisms underlying ATF2 targ
Autor:
Kerstin Stemmer, Stephen C. Woods, Harvey J. Grill, Jens J. Holst, Alessandro Pocai, Michael A. Nauck, Andreas Fritsche, Richard D. DiMarchi, David A. D'Alessio, Mads Tang-Christensen, Diego Perez-Tilve, Darleen A. Sandoval, Randy J. Seeley, Wolfgang Langhans, Daniel J. Drucker, Stephen R. Bloom, M.H. Tschöp, Brian Finan, Fiona M. Gribble, Timo D. Müller, Peter R. Flatt, Joel F. Habener, Juris J. Meier, Thue W. Schwartz, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 30, Iss, Pp 72-130 (2019)
Molecular Metabolism
Molecular Metabolism, 30
Mueller, T D, Finan, B, Bloom, S R, D'Alessio, D, Drucker, D J, Flatt, P R, Fritsche, A, Gribble, F, Grill, H J, Habener, J F, Holst, J J, Langhans, W, Meier, J J, Nauck, M A, Perez-Tilve, D, Pocai, A, Reimann, F, Sandoval, D A, Schwartz, T W, Seeley, R J, Stemmer, K, Tang-Christensen, M, Woods, S C, DiMarchi, R D & Tschoep, M H 2019, ' Glucagon-like peptide 1 (GLP-1) ', Molecular Metabolism, vol. 30, pp. 72-130 . https://doi.org/10.1016/j.molmet.2019.09.010
Molecular Metabolism
Molecular Metabolism, 30
Mueller, T D, Finan, B, Bloom, S R, D'Alessio, D, Drucker, D J, Flatt, P R, Fritsche, A, Gribble, F, Grill, H J, Habener, J F, Holst, J J, Langhans, W, Meier, J J, Nauck, M A, Perez-Tilve, D, Pocai, A, Reimann, F, Sandoval, D A, Schwartz, T W, Seeley, R J, Stemmer, K, Tang-Christensen, M, Woods, S C, DiMarchi, R D & Tschoep, M H 2019, ' Glucagon-like peptide 1 (GLP-1) ', Molecular Metabolism, vol. 30, pp. 72-130 . https://doi.org/10.1016/j.molmet.2019.09.010
Background: The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, in
Autor:
Ruth Gutierrez-Aguilar, Bernadette E. Grayson, Dong-Hoon Kim, Suma Yalamanchili, Mario L. Calcagno, Stephen C. Woods, Randy J. Seeley
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Frontiers in Nutrition
Frontiers in Nutrition
GNPDA2 has been associated with human obesity and type-2 diabetes by using a GWAS approach. GNPDA2 is an enzyme involved in the hexosamine biosynthesis pathway, which is known to be important for nutrient sensing in various organism. Its counter enzy
Autor:
Caitlin S. Mitchell, David Cameron-Smith, Christopher P. Antoniadis, Stephen C. Woods, Garth Bennett, Denovan P. Begg, Markandeya Jois, Lauren. Stahl, Maria Lambrou, Elizabeth Barber, Shirmila D Premaratna, Richard S. Weisinger
Publikováno v:
Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 12 (2021)
Frontiers in Endocrinology, Vol 12 (2021)
Obesity is a growing health problem worldwide. The renin-angiotensin system (RAS) is present in adipose tissue, and evidence suggests that it is involved in both diet-induced obesity and the inflammation associated with obesity. The present experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18095abf9e609404a407184c9e6b8748