Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Stephen C Mack"'
Autor:
Stephanie M. Casillo, Taylor A. Gatesman, Akanksha Chilukuri, Srinidhi Varadharajan, Brenden J. Johnson, Daniel R. David Premkumar, Esther P. Jane, Tritan J. Plute, Robert F. Koncar, Ann-Catherine J. Stanton, Carlos A.O. Biagi-Junior, Callie S. Barber, Matthew E. Halbert, Brian J. Golbourn, Katharine Halligan, Andrea F. Cruz, Neveen M. Mansi, Allison Cheney, Steven J. Mullett, Clinton Van’t Land, Jennifer L. Perez, Max I. Myers, Nishant Agrawal, Joshua J. Michel, Yue-Fang Chang, Olena M. Vaske, Antony MichaelRaj, Frank S. Lieberman, James Felker, Sruti Shiva, Kelsey C. Bertrand, Nduka Amankulor, Costas G. Hadjipanayis, Kalil G. Abdullah, Pascal O. Zinn, Robert M. Friedlander, Taylor J. Abel, Javad Nazarian, Sriram Venneti, Mariella G. Filbin, Stacy L. Gelhaus, Stephen C. Mack, Ian F. Pollack, Sameer Agnihotri
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113557- (2024)
Summary: Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced by the hallmark histone mutation H3K27M, which results in aberrantly permissive activation of oncogenic signaling pathways. Previous stu
Externí odkaz:
https://doaj.org/article/a1cfb726d57743518bf0449e2947643f
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 39, Iss , Pp 100895- (2023)
Pediatric intracranial ependymoma has seen a recent exponential expansion of biological findings, rapidly dividing the diagnosis into several subgroups, each with specific molecular and clinical characteristics. While such subdivision may complicate
Externí odkaz:
https://doaj.org/article/47fd6b923a984b0892d3df6321ff8cfa
Autor:
Maral Adel Fahmideh, Erin C. Peckham-Gregory, Jeremy M. Schraw, Murali Chintagumpala, Stephen C. Mack, Philip J. Lupo, Michael E. Scheurer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Central nervous system (CNS) tumors are the most common solid tumors in children. Findings on the role of maternal and perinatal factors on the susceptibility or outcome of these tumors are inconclusive. Therefore, we investigated the associ
Externí odkaz:
https://doaj.org/article/93f68e664e064a78ac2cb4d67923e098
Autor:
Kelsey C. Bertrand, Claudia C. Faria, Patryk Skowron, Amanda Luck, Livia Garzia, Xiaochong Wu, Sameer Agnihotri, Christian A. Smith, Michael D. Taylor, Stephen C. Mack, James T. Rutka
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-6 (2018)
Externí odkaz:
https://doaj.org/article/64fe9f3c9b454bd190750b750ab62df1
Autor:
Han Zou, Bradley Poore, Emily E. Brown, Jieqi Qian, Bin Xie, Evridiki Asimakidou, Vladislav Razskazovskiy, Deanna Ayrapetian, Vaibhav Sharma, Shunjin Xia, Fei Liu, Apeng Chen, Yongchang Guan, Zhengwei Li, Siyi Wanggou, Olivier Saulnier, Michelle Ly, Wendy Fellows-Mayle, Guifa Xi, Tadanori Tomita, Adam C. Resnick, Stephen C. Mack, Eric H. Raabe, Charles G. Eberhart, Dandan Sun, Beth E. Stronach, Sameer Agnihotri, Gary Kohanbash, Songjian Lu, Karl Herrup, Jeremy N. Rich, George K. Gittes, Alberto Broniscer, Zhongliang Hu, Xuejun Li, Ian F. Pollack, Robert M. Friedlander, Sarah J. Hainer, Michael D. Taylor, Baoli Hu
Publikováno v:
Nature Cell Biology. 25:493-507
How abnormal neurodevelopment relates to the tumour aggressiveness of medulloblastoma (MB), the most common type of embryonal tumour, remains elusive. Here we uncover a neurodevelopmental epigenomic programme that is hijacked to induce MB metastatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0f51592b0e8eb2d91bf16cf1f0905d6
https://doi.org/10.1038/s41556-023-01093-0
https://doi.org/10.1038/s41556-023-01093-0
Autor:
Andrea J. Cohen, Alina Saiakhova, Olivia Corradin, Jennifer M. Luppino, Katreya Lovrenert, Cynthia F. Bartels, James J. Morrow, Stephen C. Mack, Gursimran Dhillon, Lydia Beard, Lois Myeroff, Matthew F. Kalady, Joseph Willis, James E. Bradner, Ruth A. Keri, Nathan A. Berger, Shondra M. Pruett-Miller, Sanford D. Markowitz, Peter C. Scacheri
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Active enhancers are defined by the presence of post-translational modifications of histones. Here, the authors use these marks to identify enhancers recurrently activated in colorectal cancer and find that these enhancers turn on oncogenes and are a
Externí odkaz:
https://doaj.org/article/5528fdc3208d403fa301effc0fea14f8
Autor:
Stephen C. Mack, Kelsey C. Bertrand
Publikováno v:
Clinical Cancer Research.
Glioblastoma (GBM) is a heterogeneous brain tumor entity from infancy through adulthood. ALK gene fusions enriched in congenital and infant GBM have emerged as druggable driver alterations. Understanding the molecular basis and prevalence of ALK gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd435d3aa534a344655a5ed8fa1d8f32
https://doi.org/10.1158/1078-0432.ccr-23-0472
https://doi.org/10.1158/1078-0432.ccr-23-0472
Autor:
Nada Jabado, Claudia L. Kleinman, Livia Garzia, Michael D. Taylor, Stephen C. Mack, Benjamin A. Garcia, Peter W. Lewis, Pierre Thibault, Jay S. Wunder, Robert Turcotte, Brendan C. Dickson, Jason Karamchandani, Sungmi Jung, Ashot S. Harutyunyan, Véronique Lisi, Robert Eveleigh, Tianna S. Sihota, Kateryna Rossokhata, Siddhant U. Jain, Takeaki Ishii, Éric Bonneil, Joel Lanoix, Dylan M. Marchione, Damien Faury, Leonie G. Mikael, Carol C.L. Chen, Wajih Jawhar, Liam D. Hendrikse, Shriya Deshmukh, Nicolas De Jay, Sima Khazaei
Differential Expression in Isogenic Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1343050be4db44fce4eca262d777317
https://doi.org/10.1158/2159-8290.22535012
https://doi.org/10.1158/2159-8290.22535012
Autor:
Stephen C. Mack, Benjamin Deneen, Kelsey C. Bertrand, Claudia L. Kleinman, Nada Jabado, Joanna Yi, Richard J. Gilbertson, Sameer Agnihotri, Kristian W. Pajtler, Donald W. Parsons, Susan M. Blaney, Murali M. Chintagumpala, Thomas F. Westbrook, Irtisha Singh, H. Courtney Hodges, Charles Y. Lin, Stefan M. Pfister, Daisuke Kawauchi, Felix Sahm, Luz A. De León, Peter R. Wang, Madeline Ngo, Sarah G. Injac, Baoli Hu, Robert Kupp, Kathleen Kong, Kristen L. Karlin, Calla Olson, Yuen San Chan, Ann-Catherine J. Stanton, Brian J. Golbourn, Dana Tlais, Alisha Kardian, Minerva Solis, Austin J. Stuckert, Bryan Rivas, Selin Jessa, Hsiao-Chi Chen, Srinidhi Varadharajan, Yanhua Zhao, Amir Arabzade
93 gene signature that characterizes ZFTA-Rela mouse and human tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2455a45bb7a7160f6ff2e0c7dedb37da
https://doi.org/10.1158/2159-8290.22539655.v1
https://doi.org/10.1158/2159-8290.22539655.v1
Autor:
Richard J. Gilbertson, Javed Khan, Berkley E. Gryder, Katherine E. Masih, Stephen C. Mack, Benjamin Deneen, Kristian W. Pajtler, Daisuke Kawauchi, Stefan M. Pfister, Mohankumar Murugesan, Tuyu Zheng, Srinidhi Varadharajan, Yanhua Zhao, Amir Arabzade, Marcus Widdess, Katherine Wickham-Rahrmann, Nadin Hoffmann, Chandra Sekhar Reddy Chilamakuri, Rory Stark, Stephane Ballereau, Erica Nathan, Sabrina Terranova, Lisa Ruff, Robert Kupp
ZFTA (C11orf95)—a gene of unknown function—partners with a variety of transcriptional coactivators in translocations that drive supratentorial ependymoma, a frequently lethal brain tumor. Understanding the function of ZFTA is key to developing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2cf8077f685aa539c0dc306a7178bc
https://doi.org/10.1158/2159-8290.c.6549395
https://doi.org/10.1158/2159-8290.c.6549395