Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Stephen C Kales"'
Autor:
Silvano Rakeem Daniels, Mariya Liyasova, Stephen C Kales, Marion M Nau, Philip E Ryan, Jeffrey E Green, Stanley Lipkowitz
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219143 (2019)
Receptor Tyrosine Kinase (RTK) signaling is essential for normal biological processes and disruption of this regulation can lead to tumor initiation and progression. Cbl proteins (Cbl, Cbl-b and Cbl-c) are a family of RING finger (RF) ubiquitin ligas
Externí odkaz:
https://doaj.org/article/79cd95f3885c45088a69cbd78b042ecb
Autor:
Lizhen Wu, Jian Cao, Wesley L Cai, Sabine M Lang, John R Horton, Daniel J Jansen, Zongzhi Z Liu, Jocelyn F Chen, Meiling Zhang, Bryan T Mott, Katherine Pohida, Ganesha Rai, Stephen C Kales, Mark J Henderson, Xin Hu, Ajit Jadhav, David J Maloney, Anton Simeonov, Shu Zhu, Akiko Iwasaki, Matthew D Hall, Xiaodong Cheng, Gerald S Shadel, Qin Yan
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2006134 (2018)
Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate
Externí odkaz:
https://doaj.org/article/b82bd2d7d5a04000a7a64e580355ce3f
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87116 (2014)
The Cbl proteins (Cbl, Cbl-b, and Cbl-c) are a highly conserved family of RING finger ubiquitin ligases (E3s) that function as negative regulators of tyrosine kinases in a wide variety of signal transduction pathways. In this study, we identify a new
Externí odkaz:
https://doaj.org/article/6a03ab554f364d1982b7553d1cc0a240
Autor:
Philip E Ryan, Stephen C Kales, Rajgopal Yadavalli, Marion M Nau, Han Zhang, Stanley Lipkowitz
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49428 (2012)
Cbl proteins (Cbl, Cbl-b and Cbl-c) are ubiquitin ligases that are critical regulators of tyrosine kinase signaling. In this study we identify a new Cbl-c interacting protein, Hydrogen peroxide Induced Construct 5 (Hic-5). The two proteins interact t
Externí odkaz:
https://doaj.org/article/28f9f8d7a876472da8f17bea2af14911
Autor:
Yi-Hung Carol Tan, Soundararajan Krishnaswamy, Suvobroto Nandi, Rajani Kanteti, Sapana Vora, Kenan Onel, Rifat Hasina, Fang-Yi Lo, Essam El-Hashani, Gustavo Cervantes, Matthew Robinson, Han-Shui Hsu, Stephen C Kales, Stanley Lipkowitz, Theodore Karrison, Martin Sattler, Everett E Vokes, Yi-Ching Wang, Ravi Salgia
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8972 (2010)
Non-small cell lung cancer (NSCLC) is a heterogeneous group of disorders with a number of genetic and proteomic alterations. c-CBL is an E3 ubiquitin ligase and adaptor molecule important in normal homeostasis and cancer. We determined the genetic va
Externí odkaz:
https://doaj.org/article/07bc66ce343e48fc911cf1cc1edddb67
Autor:
Qin Yan, Marcus W. Bosenberg, Daniel P. Kelly, Matthew D. Hall, Anton Simeonov, Stephen C. Kales, Daniel J. Jansen, Ling Lai, Irina Krykbaeva, Meaghan K. McGeary, Shang-Min Zhang, Xiaoni Liu
Tumor heterogeneity is a major challenge for cancer treatment, especially due to the presence of various subpopulations with stem cell or progenitor cell properties. In mouse melanomas, both CD34+p75− (CD34+) and CD34−p75− (CD34−) tumor subpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::067c56d0d5b3eb34e6f9c5b1dfc605d1
https://doi.org/10.1158/1535-7163.c.6538539.v1
https://doi.org/10.1158/1535-7163.c.6538539.v1
Autor:
Qin Yan, Marcus W. Bosenberg, Daniel P. Kelly, Matthew D. Hall, Anton Simeonov, Stephen C. Kales, Daniel J. Jansen, Ling Lai, Irina Krykbaeva, Meaghan K. McGeary, Shang-Min Zhang, Xiaoni Liu
Figure S1. Responses of different YUMM cell lines to BRAFi treatment; Figure S2. Inhibition of KDM5 family members by shRNA knockdown and pan-KDM5 inhibitors; Figure S3. Subpopulation composition in tumors of different volumes; Figure S4. In vivo BRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29b44f79f8fe1852f77e511980e40fd
https://doi.org/10.1158/1535-7163.22506975
https://doi.org/10.1158/1535-7163.22506975
Autor:
Jonathan H. Shrimp, John Janiszewski, Catherine Z. Chen, Miao Xu, Kelli M. Wilson, Stephen C. Kales, Philip E. Sanderson, Paul Shinn, Rick Schneider, Zina Itkin, Hui Guo, Min Shen, Carleen Klumpp-Thomas, Samuel G. Michael, Wei Zheng, Anton Simeonov, Matthew D. Hall
Publikováno v:
ACS Infectious Diseases. 8:1191-1203
SARS-CoV-2 is the causative viral pathogen driving the COVID-19 pandemic that prompted an immediate global response to the development of vaccines and antiviral therapeutics. For antiviral therapeutics, drug repurposing allows for rapid movement of t
Autor:
Anna R. Panchenko, Stanley Lipkowitz, Andrew L. Cangelosi, Juan Crespo-Barreto, Benjamin A. Shoemaker, Ke Ma, Stephen C. Kales, Minghui Li
Fig. S1. The distribution of unfolding and binding free energy changes for Single, Recurrent and Random class mutations for all states in CBL activation cycle. Fig.S2. The distribution of local RMSD of mutant structures for Single, Recurrent and Rand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb546c494c2f73006222586e7feb390
https://doi.org/10.1158/0008-5472.22409519.v1
https://doi.org/10.1158/0008-5472.22409519.v1
Autor:
Anna R. Panchenko, Stanley Lipkowitz, Andrew L. Cangelosi, Juan Crespo-Barreto, Benjamin A. Shoemaker, Ke Ma, Stephen C. Kales, Minghui Li
Detailed description of methods for computational modeling and analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca8c934d75e8eafa86e7076d2ad1688
https://doi.org/10.1158/0008-5472.22409516.v1
https://doi.org/10.1158/0008-5472.22409516.v1