Intramuscular depot medroxyprogesterone acetate accentuates bone loss associated with tenofovir disoproxil fumarate-containing antiretroviral therapy initiation in young women living with HIV (the BONE: CARE study): a prospective cohort study in Uganda

Autor: Flavia Kiweewa Matovu, Noah Kiwanuka, Martin Nabwana, Delia Scholes, Philippa Musoke, Mary Glenn Fowler, Mags E Beksinska, John M Pettifor, Todd T Brown, Flavia Matovu Kiweewa, Clemensia Nakabiito, Faith Nawagi, Betty Kamira, Esther Isingel, Stephen Bule, Violet Kukundakwe, Andrew Kateregga, Mary (Maria) Musisi, Paula Mubiru Namayanja, Dorothy Mirembe, Mary Speciosa Mbabali, Sarah Mulebeke, Joselyne Nabisere, Joyce Nakakande, Nicholas Matovu, Dorah Nakaye, Joshua Wynne, Faith Mulumba, Restituta Mukasa, Masitula Ssewanyana, Hadijah Kalule Nabunya, Florence Asiimwe Biira, Erinah Kyomukama, Suzan Nampiira, Aisha Zalwago, Margaret l Namuganga, Deborah Mwebaza, Prossy Ethel Namuli, Caroline Tulina, Florence Sempa Kikonyogo, Regina Bukenya Nabatanzi, Rosemary Muwawu, Jane Nsubuga Musisi, Margaret Nakato Saava, Mary Mukasa Kagwa Najjemba, Winfred Kaahwa, Rose Namwanje Mukalazi, Miriam Magomu Takhuli, Osman Sawsan, Margaret Mugenyi, Mary Agnes Mugagga, Francis Sserugo, Agnes Namuddu, Doreen Kemigisha, Justine Nakyeyune, Caroline Kawuma Nassozi, Juliet Asello, Zaam Zinda Nakawungu, Olivia Higiro Kaboggoza, Sarah Babirye Ssebabi, Bertha Birungi, Ruth Lutabi Ssentogo, Michael Charles Mubiru, Winnie Nansamba, Stella Nalusiba Kalungi, Luke Erismus Bukenya, Prossy Asiimwe, James Amos Bazira, Sulaiman Katongole, Wenceslaus Twinomujuni, Susan Nakacwa, Joanita Nankya Baddokwaya, Alice Margaret Elwana, Juliet Nanyonjo, Susan Adikini, Justine Nalwoga, Godfrey Rwanzogyera, Fabian Okello, Daniel Kabenge Kiiza, Emmanuel Mayanja, Francis Katongole, Max Kiwewa, Francis Onen, Joseph Mutebo, Dick Mukasa, Joshua Tamale, Ismael Kibirige

Publikováno v: The Lancet. Global health. 10(5)

Tenofovir disoproxil fumarate (TDF) and intramuscular depot medroxyprogesterone acetate (DMPA-IM) are independently associated with reduced bone mineral density (BMD). We aimed to assess the combined effects of DMPA-IM use and TDF initiation on BMD i

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https://pubmed.ncbi.nlm.nih.gov/35427508