Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

Autor: Nicholas A Kennedy, Graham A Heap, Harry D Green, Benjamin Hamilton, Claire Bewshea, Gareth J Walker, Amanda Thomas, Rachel Nice, Mandy H Perry, Sonia Bouri, Neil Chanchlani, Neel M Heerasing, Peter Hendy, Simeng Lin, Daniel R Gaya, J R Fraser Cummings, Christian P Selinger, Charlie W Lees, Ailsa L Hart, Miles Parkes, Shaji Sebastian, John C Mansfield, Peter M Irving, James Lindsay, Richard K Russell, Timothy J McDonald, Dermot McGovern, James R Goodhand, Tariq Ahmad, Vinod Patel, Zia Mazhar, Rebecca Saich, Ben Colleypriest, Tony C Tham, Tariq H Iqbal, Vishal Kaushik, Senthil Murugesan, Salil Singh, Sean Weaver, Cathryn Preston, Assad Butt, Melissa Smith, Dharamveer Basude, Amanda Beale, Sarah Langlands, Natalie Direkze, Franco Torrente, Juan De La Revella Negro, Chris Ewen MacDonald, Stephen M Evans, Anton V J Gunasekera, Alka Thakur, David Elphick, Achuth Shenoy, Chuka U Nwokolo, Anjan Dhar, Andrew T Cole, Anurag Agrawal, Stephen Bridger, Julie Doherty, Sheldon C Cooper, Shanika de Silva, Craig Mowat, Phillip Mayhead, Charlie Lees, Gareth Jones, James W Hart, Lisa Gervais, Paul Dunckley, Tariq Mahmood, Paul J R Banim, Sunil Sonwalkar, Deb Ghosh, Rosemary H Phillips, Amer Azaz, Richard Shenderey, Lawrence Armstrong, Claire Bell, Radhakrishnan Hariraj, Helen Matthews, Hasnain Jafferbhoy, Veena Zamvar, John S De Caestecker, Anne Willmott, Richard Miller, Palani Sathish Babu, Christos Tzivinikos, Stuart L Bloom, Guy Chung-Faye, Nicholas M Croft, John ME Fell, Marcus Harbord, Ailsa Hart, Ben Hope, James O Lindsay, Joel E Mawdsley, Alistair McNair, Kevin J Monahan, Charles D Murray, Timothy Orchard, Thankam Paul, Richard Pollok, Neil Shah, Matt W Johnson, Anita Modi, Kasamu Dawa Kabiru, B K Baburajan, Bim Bhaduri, Andrew Adebayo Fagbemi, Scott Levison, Jimmy K Limdi, Gill Watts, Stephen Foley, Arvind Ramadas, George MacFaul, John Mansfield, Leonie Grellier, Mary-Anne Morris, Mark Tremelling, Chris Hawkey, Sian Kirkham, Charles PJ Charlton, Astor Rodrigues, Alison Simmons, Stephen J Lewis, Jonathon Snook, Mark Tighe, Patrick M Goggin, Aminda N De Silva, Simon Lal, Mark S Smith, Simon Panter, Suranga Dharmisari, Martyn Carter, David Watts, Zahid Mahmood, Bruce McLain, Sandip Sen, Anna J Pigott, David Hobday, Emma Wesley, Richard Johnston, Cathryn Edwards, John Beckly, Deven Vani, Subramaniam Ramakrishnan, Rakesh Chaudhary, Nigel J Trudgill, Rachel Cooney, Andy Bell, Neeraj Prasad, John N Gordon, Matthew J Brookes, Andy Li, Stephen Gore

Publikováno v: The Lancet Gastroenterology & Hepatology. 4:341-353

BACKGROUND: Anti-TNF drugs are effective treatments for the management of Crohn's disease but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors that predict primary non-response at week 14 after starting treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cf9cdaaf826d8961db6241a4505d59
https://doi.org/10.1016/s2468-1253(19)30012-3

PTU-114 Safety of accelerated infliximab infusion in inflammatory bowel disease in a district general hospital

Autor: Rosetta Wilson, James Jupp, Stephen Bridger, Elizabeth Webb, Annie Lock, Pearl Avery, Jeffrey Luk, Angel Castro-Silva, J Shutt

Publikováno v: Gastroenterology Service.

Introduction Our district general hospital serves a population of around 3 30 000 with 1325 active Inflammatory Bowel Disease (IBD) patients. A small percentage of these patients receive infliximab infusions for disease control. The British National

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::792e6f3814ef8e74433ba77b59a09023
https://doi.org/10.1136/gutjnl-2018-bsgabstracts.492

Linkage of Inflammatory Bowel Disease to Human Chromosome 6p

Autor: Robert Saiz, Stefan Schreiber, Silvia Mascheretti, Pieter C. F. Stokkers, Sarah H. Shaw, Nancy J. Leysens, Nicholas J. Lynch, Annette Lantermann, Mark E. Curran, John E. Lennard-Jones, Christopher G. Mathew, Phil Morin, Alastair Forbes, Stephen Bridger, Mudassar M. Mirza, Sander J. H. van Deventer, A Macpherson, Jochen Hampe

Publikováno v: American journal of human genetics, 65(6), 1647-1655. Cell Press

Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease and ulcerative colitis phenotypes. Given the immunologic dysregulation in IBD, the human-leukocyte-antigen region o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081363678ea6762071110b621b2058fc

PTU-059 Early Experience with Biosimilar Infliximab at a District General Hospital for an Entire Crohns Disease Patient Cohort Switch from Remicade to Inflectra

Autor: J Jupp, Rosetta Wilson, Pearl Avery, J Shutt, A Prowse, Stephen Bridger, K Ala

Publikováno v: Gut. 65:A81-A81

Introduction Switching from an established biologic to a biosimilar to save costs was considered likely to be ‘inappropriate and ineffective’ by ECCO.1 Methods With Area Prescribing Committee approval, all Crohns disease (CD) patients established

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16dfb1f5204ecd2e7ac46dd28ef85b9e
https://doi.org/10.1136/gutjnl-2016-312388.145

The use of oxygen uptake rate to monitor discovery of microbial and enzymatic biocatalysts

Autor: Geoff Dumsday, Gunseli Ocal, John Stephen Bridger, Michael Zachariou

Publikováno v: Biotechnology and bioengineering. 102(3)

Arising from the requirement for discovery of novel biocatalysts with unusual properties, a process was developed which uniquely combines aspects of continuous culture with the measurement of oxygen uptake. This adaptation of the chemostat can be use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0e0e762cf0048437af9fa966609b78
https://pubmed.ncbi.nlm.nih.gov/19090578