Výsledky vyhledávání - "Stephen Bowlin"

In Vitro Metabolism of Slowly Cleared G Protein-Coupled Receptor 139 Agonist TAK-041 Using Rat, Dog, Monkey, and Human Hepatocyte Models (HepatoPac): Correlation with In Vivo Metabolism

Autor: Natalie Hosea, Stephen Bowlin, Antonio Laurenza, Dimitrios Arkilo, Amin Kamel

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 49(2)

Hepatic metabolism of low-clearance compound TAK-041 was studied in two different in vitro model systems using rat, dog, monkey, and human suspended cryopreserved hepatocytes and HepatoPac micropatterned coculture model primary hepatocytes. The aim o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fde562f04e0bbaf480b94622943ea33
https://pubmed.ncbi.nlm.nih.gov/33273044

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In Vitro Biotransformation of the Nrf2 Activator Bardoxolone: Formation of an Epoxide Metabolite That Undergoes Two Novel Glutathione-Mediated Metabolic Pathways: Epoxide Reduction and Oxidative Elimination of Nitrile Moiety

Autor: Ian A. Blair, Ban Anwar, Stephen Bowlin, Holly Reichard, Joseph P. Argus, Amin Kamel

Publikováno v: Chem Res Toxicol

Metabolism of bardoxolone methyl (BARD-Me), an oleanolic acid derivative, and its epoxide metabolite was studied in different in vitro systems. BARD-Me also undergoes glutathione (GSH)-adduct formation via direct nucleophilic attack at the β-carbon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3847a52f0ca01d064d5d5022a1090152
https://pubmed.ncbi.nlm.nih.gov/31613099

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Catabolism of antibody drug conjugates and characterization methods

Autor: Stephen Bowlin, Jayaprakasam Bolleddula, Mohammad Shadid

Publikováno v: Bioorganicmedicinal chemistry. 25(12)

Antibody drug conjugates (ADCs) are large molecule therapeutics in which a cytotoxic payload is conjugated to a monoclonal antibody (mAb) via a linker. The molecules are designed to selectively bind to target-expressing cells, thus delivering therape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba64e552d3ad2bd9f1ae84cbd2a8fb8
https://pubmed.ncbi.nlm.nih.gov/28438386

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In vitro metabolic activation of thiabendazole via 5-hydroxythiabendazole: identification of a glutathione conjugate of 5-hydroxythiabendazole

Autor: Evan Smith, Alan Deese, Deepak Dalvie, Stephen Bowlin

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 34(4)

Thiabendazole (TBZ) is a broad-spectrum antihelmintic used for treatment of parasitic infections in animals and humans and as an agricultural fungicide for postharvest treatment of fruits and vegetables. It is teratogenic and nephrotoxic in mice, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d4d72b665110fccf29df92768aee0b
https://pubmed.ncbi.nlm.nih.gov/16434547

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