Výsledky vyhledávání - "Stephen Blakemore"

Akademický článek

BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™) induces tumor localized CD137 agonism

Autor: Jun Ma, Kristen Hurov, Johanna lahdenranta, Punit Upadhyaya, Elizabeth Repash, Julia Kristensson, Eric Haines, Kevin McDonnell, Philip Brandish, Nicholas Keen, Fanglei You, Mike Kelly, Heather Cohen, Drasti Kanakia, Carly Campbell, David Witty, Stephen Blakemore, Phil Jeffrey

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)

Externí odkaz: https://doaj.org/article/4724c01b9ec7407d90abf3570e647883

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Akademický článek

2 Quantitation of CD137 and Nectin-4 expression across multiple tumor types to support indication selection for BT7480, a Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™)

Autor: Mate Nagy, Kristen Hurov, Johanna lahdenranta, Nicholas Keen, Dominic Smethurst, Qingyan Au, Heather Cohen, Carly Campbell, Stephen Blakemore, Tara Gelb, David Galbraith, Dan Rozelle, Erinn Parnell, Phil Brandish, Sebastien Hazard

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Externí odkaz: https://doaj.org/article/102a84b0e197487c962ac3bde6fc8f41

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Data from Disrupting Protein NEDDylation with MLN4924 Is a Novel Strategy to Target Cisplatin Resistance in Ovarian Cancer

Autor: Jennifer S. Carew, Allison Berger, Michael Thomas, Stephen Blakemore, Michael Milhollen, Sean A. Beausoleil, Anthony Possemato, Claudia M. Espitia, Peter G. Smith, Kevin R. Kelly, Steffan T. Nawrocki

Purpose: Ovarian cancer has the highest mortality rate of all female reproductive malignancies. Drug resistance is a major cause of treatment failure and novel therapeutic strategies are urgently needed. MLN4924 is a NEDDylation inhibitor currently u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbb66a754615a2340af9aba36490809
https://doi.org/10.1158/1078-0432.c.6522186.v1

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Supplementary Figure 1 from Disrupting Protein NEDDylation with MLN4924 Is a Novel Strategy to Target Cisplatin Resistance in Ovarian Cancer

PDF file - 1755K, Supplemental Figure 1: Effects of targeted p65 knockdown on cisplatin sensitivity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627036159925f122bbe6cee401c9efba
https://doi.org/10.1158/1078-0432.22451391

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Supplementary Table 1 from Disrupting Protein NEDDylation with MLN4924 Is a Novel Strategy to Target Cisplatin Resistance in Ovarian Cancer

PDF file - 71K, Supplemental Table 1. Proteins Altered >2-fold by Treatment with MLN4924.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0b67ed86626b6eb94f1ada6e5c926e
https://doi.org/10.1158/1078-0432.22451385

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Supplementary Figure 2 from Disrupting Protein NEDDylation with MLN4924 Is a Novel Strategy to Target Cisplatin Resistance in Ovarian Cancer

PDF file - 3554K, Supplemental Figure 2: Effects of caspase inhibition and antioxidant treatment on MLN4924/cisplatin-induced DNA damage.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a0198af11e49361783b5d136b4d01d
https://doi.org/10.1158/1078-0432.22451388

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BT7480, a novel fully synthetic

Autor: Kristen, Hurov, Johanna, Lahdenranta, Punit, Upadhyaya, Eric, Haines, Heather, Cohen, Elizabeth, Repash, Drasti, Kanakia, Jun, Ma, Julia, Kristensson, Fanglei, You, Carly, Campbell, David, Witty, Mike, Kelly, Stephen, Blakemore, Phil, Jeffrey, Kevin, McDonnell, Philip, Brandish, Nicholas, Keen

Publikováno v: Journal for Immunotherapy of Cancer

Background CD137 (4-1BB) is an immune costimulatory receptor with high therapeutic potential in cancer. We are creating tumor target-dependent CD137 agonists using a novel chemical approach based on fully synthetic constrained bicyclic peptide (Bicyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4e1d5371e1c2ab609b1f42b7db38751b
https://pubmed.ncbi.nlm.nih.gov/34725211

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Elektronická kniha

Recovering the Soul : Aquinas’s and Spinoza’s Surprising and Helpful Affinity on the Nature of Mind-Body Unity

Autor: G. Stephen Blakemore

Recovering the Soul explores an area of historical philosophy that few if any others have attempted by critically comparing the metaphysical doctrines of Thomas Aquinas and Baruch Spinoza on the identity of mind and body. The central premise is that

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CURRENT PERSPECTIVES IN CANCER THERAPY

Autor: Isidor Schwaner Ravdin, William Stephen Blakemore

Publikováno v: The American Journal Of The Medical Sciences. 252:377

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1db441d7d1f53031a0be5423bf80539b
https://doi.org/10.1097/00000441-196609000-00026

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