Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Stephen B. Wheatcroft"'
Autor:
Andrew MN Walker, Nicole T. Watt, Nadira Y. Yuldasheva, Sanjush Dalmia, Marcella Conning-Rowland, Chew W. Cheng, Nele Warmke, Katherine Bridge, Oliver I. Brown, Cheukyau Luk, Michael Drozd, Natalie J. Haywood, Anna Skromna, Natasha Makava, Stephen B. Wheatcroft, Mark T. Kearney, Richard M. Cubbon
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e36457- (2024)
Objective: Reduced IGF-1 signalling is an evolutionarily conserved mediator of longevity, yet the magnitude of this effect is substantially larger in organisms retaining a common insulin and IGF-1 receptor. Whether this reflects the failure to simult
Externí odkaz:
https://doaj.org/article/8e31cd24581c4d399766217804bdc0d5
Autor:
Shane Parfrey, Amr Abdelrahman, Daniel Blackman, Jonathan M. Blaxill, Michael S. Cunnington, John P. Greenwood, Christopher J. Malkin, Abdul M. Mozid, Jennifer A. Rossington, Murugapathy Veerasamy, Nancy Wassef, Stephen B. Wheatcroft, Heerajnarain Bulluck
Publikováno v:
BMC Cardiovascular Disorders, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Very short duration of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) has recently attracted a lot of attention with the introduction of newer generations stents. This is appealing, especially in patients
Externí odkaz:
https://doaj.org/article/53ff4a31117941ec854b814dec536678
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 22, p 6976 (2023)
Intracoronary guidewires used in percutaneous coronary intervention can also be configured to provide temporary ventricular pacing. Trans coronary electrophysiological parameters recorded by employing coronary guidewires may have a potential role in
Externí odkaz:
https://doaj.org/article/00933636fffc40e08151d98c601ffad9
Autor:
Hansa Iqbal, Sam Straw, Thomas P. Craven, Katherine Stirling, Stephen B. Wheatcroft, Klaus K. Witte
Publikováno v:
ESC Heart Failure, Vol 7, Iss 5, Pp 2032-2041 (2020)
Abstract Aims Left ventricular (LV) thrombus is increasingly detected in patients with and without ischaemic heart disease due to the increased availability of cardiac magnetic resonance imaging. Risk factors include anterior ST elevation myocardial
Externí odkaz:
https://doaj.org/article/ece46dd43fde45bea74cbd3669e9f313
Autor:
Annette M. Maznyczka, Connor J. Matthews, Jonathan M. Blaxill, John P. Greenwood, Abdul M. Mozid, Jennifer A. Rossington, Murugapathy Veerasamy, Stephen B. Wheatcroft, Nick Curzen, Heerajnarain Bulluck
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 23, p 7092 (2022)
Background and Aims: Randomised controlled trials (RCTs) comparing outcomes after fractional flow reserve (FFR)-guided versus angiography-guided management for obstructive coronary artery disease (CAD) have produced conflicting results. We investigat
Externí odkaz:
https://doaj.org/article/39948c60ac314c218b5ba8851c3fdfe9
Autor:
Talia Caspi, Sam Straw, Chew Cheng, Jack O Garnham, Jason L. Scragg, Jessica Smith, Aaron O. Koshy, Eylem Levelt, Piruthivi Sukumar, John Gierula, David J. Beech, Mark T. Kearney, Richard M. Cubbon, Stephen B. Wheatcroft, Klaus K. Witte, Lee D. Roberts, T. Scott Bowen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 18 (2020)
Background People with chronic heart failure (CHF) experience severe skeletal muscle dysfunction, characterized by mitochondrial abnormalities, which exacerbates the primary symptom of exercise intolerance. However, the molecular triggers and charact
Externí odkaz:
https://doaj.org/article/77f1fe2c40ff4e25b5657d33ba7106ee
Autor:
Gina A. Smith, Gareth W. Fearnley, Izma Abdul-Zani, Stephen B. Wheatcroft, Darren C. Tomlinson, Michael A. Harrison, Sreenivasan Ponnambalam
Publikováno v:
Biology Open, Vol 6, Iss 10, Pp 1404-1415 (2017)
Cell surface receptors can undergo recycling or proteolysis but the cellular decision-making events that sort between these pathways remain poorly defined. Vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor
Externí odkaz:
https://doaj.org/article/0083afd86eff426b9d979f5c7df686ce
Autor:
Baptiste Rode, Jian Shi, Naima Endesh, Mark J. Drinkhill, Peter J. Webster, Sabine J. Lotteau, Marc A. Bailey, Nadira Y. Yuldasheva, Melanie J. Ludlow, Richard M. Cubbon, Jing Li, T. Simon Futers, Lara Morley, Hannah J. Gaunt, Katarzyna Marszalek, Hema Viswambharan, Kevin Cuthbertson, Paul D. Baxter, Richard Foster, Piruthivi Sukumar, Andrew Weightman, Sarah C. Calaghan, Stephen B. Wheatcroft, Mark T. Kearney, David J. Beech
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The mechanisms that regulate the body’s response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial
Externí odkaz:
https://doaj.org/article/7f62f67aa840473d94edc1b8db9c890a
Autor:
Gareth W. Fearnley, Izma Abdul-Zani, Antony M. Latham, Monica C. Hollstein, John E. Ladbury, Stephen B. Wheatcroft, Adam F. Odell, Sreenivasan Ponnambalam
Publikováno v:
Biology Open, Vol 8, Iss 5 (2019)
New blood vessel sprouting (angiogenesis) and vascular physiology are fundamental features of metazoan species but we do not fully understand how signal transduction pathways regulate diverse vascular responses. The vascular endothelial growth factor
Externí odkaz:
https://doaj.org/article/ef45472a0e93452798833e10eec2a677
Autor:
Gareth W. Fearnley, Gina A. Smith, Izma Abdul-Zani, Nadira Yuldasheva, Nadeem A. Mughal, Shervanthi Homer-Vanniasinkam, Mark T. Kearney, Ian C. Zachary, Darren C. Tomlinson, Michael A. Harrison, Stephen B. Wheatcroft, Sreenivasan Ponnambalam
Publikováno v:
Biology Open, Vol 5, Iss 5, Pp 571-583 (2016)
Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase VEGFR2 triggers multiple signal transduction pathways, which regulate endothelial cell responses that control vascular development. Multiple isoforms of VEGF-A can
Externí odkaz:
https://doaj.org/article/3e3d9e669a4f443da487cf76e60f7baf