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pro vyhledávání: '"Stephen B. Hladky"'
Autor:
Stephen B. Hladky, Margery A. Barrand
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-57 (2024)
Abstract The principles of cerebrospinal fluid (CSF) production, circulation and outflow and regulation of fluid volumes and pressures in the normal brain are summarised. Abnormalities in these aspects in intracranial hypertension, ventriculomegaly a
Externí odkaz:
https://doaj.org/article/155f087f3be94504b0ab82d570bc5519
Autor:
Stephen B. Hladky, Margery A. Barrand
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-33 (2024)
Abstract Oedema occurs when higher than normal amounts of solutes and water accumulate in tissues. In brain parenchymal tissue, vasogenic oedema arises from changes in blood–brain barrier permeability, e.g. in peritumoral oedema. Cytotoxic oedema a
Externí odkaz:
https://doaj.org/article/5834146ff5ae452e9abbf869a9c4caa8
Autor:
Stephen B. Hladky, Margery A. Barrand
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-33 (2022)
Abstract The glymphatic hypothesis proposes a mechanism for extravascular transport into and out of the brain of hydrophilic solutes unable to cross the blood–brain barrier. It suggests that there is a circulation of fluid carrying solutes inwards
Externí odkaz:
https://doaj.org/article/c0ac41c68a614fd997b1bfa7decfa073
Autor:
Stephen B. Hladky, Margery A. Barrand
Publikováno v:
Fluids and Barriers of the CNS, Vol 15, Iss 1, Pp 1-73 (2018)
Abstract This review considers efflux of substances from brain parenchyma quantified as values of clearances (CL, stated in µL g−1 min−1). Total clearance of a substance is the sum of clearance values for all available routes including perivascu
Externí odkaz:
https://doaj.org/article/741fc964c0344ee6ae1631095b82ade9
Autor:
Stephen B. Hladky, Margery A. Barrand
Publikováno v:
Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-3 (2019)
Abstract Solutes can enter and leave gray matter in the brain by perivascular routes. The glymphatic hypothesis supposes that these movements are a consequence of inward flow along periarterial spaces and an equal outward flow along perivenous spaces
Externí odkaz:
https://doaj.org/article/5c8f932afc064c45b3a065faee088278
Autor:
Margery A. Barrand, Stephen B. Hladky
Publikováno v:
Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-3 (2019)
Fluids and Barriers of the CNS
Fluids and Barriers of the CNS
Solutes can enter and leave gray matter in the brain by perivascular routes. The glymphatic hypothesis supposes that these movements are a consequence of inward flow along periarterial spaces and an equal outward flow along perivenous spaces. The flo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78089bdd1cd819518188b05ef937f002
http://link.springer.com/article/10.1186/s12987-019-0141-x
http://link.springer.com/article/10.1186/s12987-019-0141-x
Autor:
Stephen B, Hladky, Margery A, Barrand
Publikováno v:
Handbook of experimental pharmacology. 253
Mechanisms for elimination of metabolites from ISF include metabolism, blood-brain barrier transport and non-selective, perivascular efflux, this last being assessed by measuring the clearance of markers like inulin. Clearance describes elimination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fee2a0337e29580f3a4ecf1943ec26f0
https://pubmed.ncbi.nlm.nih.gov/28744585
https://pubmed.ncbi.nlm.nih.gov/28744585
Autor:
Margery A. Barrand, Stephen B. Hladky
Publikováno v:
Sleep-Wake Neurobiology and Pharmacology ISBN: 9783030112707
Mechanisms for elimination of metabolites from ISF include metabolism, blood–brain barrier transport and non-selective, perivascular efflux, this last being assessed by measuring the clearance of markers like inulin. Clearance describes elimination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13711b543b25cb2969790e91bef4ed17
https://doi.org/10.1007/164_2017_37
https://doi.org/10.1007/164_2017_37
Ion transporters in brain endothelial cells that contribute to formation of brain interstitial fluid
Publikováno v:
Pflugers Archiv
Ions and water transported across the endothelium lining the blood–brain barrier contribute to the fluid secreted into the brain and are important in maintaining appropriate volume and ionic composition of brain interstitial fluid. Changes in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e92d047aa9430193af20a125622918
http://europepmc.org/articles/PMC4006130
http://europepmc.org/articles/PMC4006130
Autor:
Stephen B. Hladky, Margery A. Barrand
Publikováno v:
Fluids and Barriers of the CNS
The two major interfaces separating brain and blood have different primary roles. The choroid plexuses secrete cerebrospinal fluid into the ventricles, accounting for most net fluid entry to the brain. Aquaporin, AQP1, allows water transfer across th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07acf0ed05f6e186471bb03879f97296
https://pubmed.ncbi.nlm.nih.gov/27799072
https://pubmed.ncbi.nlm.nih.gov/27799072