Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Stephen B Shears"'
Autor:
Rizwan Yousaf, Chunfang Gu, Zubair M Ahmed, Shaheen N Khan, Thomas B Friedman, Sheikh Riazuddin, Stephen B Shears, Saima Riazuddin
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007297 (2018)
Autosomal recessive nonsyndromic hearing loss is a genetically heterogeneous disorder. Here, we report a severe-to-profound sensorineural hearing loss locus, DFNB100 on chromosome 5q13.2-q23.2. Exome enrichment followed by massive parallel sequencing
Externí odkaz:
https://doaj.org/article/82cbaa41f0b04304a24ab3821e971473
Autor:
Brandi M Baughman, Huanchen Wang, Yi An, Dmitri Kireev, Michael A Stashko, Henning J Jessen, Kenneth H Pearce, Stephen V Frye, Stephen B Shears
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0180272 (2017)
Externí odkaz:
https://doaj.org/article/d01b745b9ec746979a07d77db60eb36a
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165286 (2016)
The HCT116 cell line, which has a pseudo-diploid karotype, is a popular model in the fields of cancer cell biology, intestinal immunity, and inflammation. In the current study, we describe two batches of diverged HCT116 cells, which we designate as H
Externí odkaz:
https://doaj.org/article/135259b3c4b649aba93ac2f4092dc70e
Autor:
Brandi M Baughman, Huanchen Wang, Yi An, Dmitri Kireev, Michael A Stashko, Henning J Jessen, Kenneth H Pearce, Stephen V Frye, Stephen B Shears
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164378 (2016)
Pharmacological tools-'chemical probes'-that intervene in cell signaling cascades are important for complementing genetically-based experimental approaches. Probe development frequently begins with a high-throughput screen (HTS) of a chemical library
Externí odkaz:
https://doaj.org/article/7ed2fec04f874d708d7332f61fb59374
Autor:
Niyas Kudukkil Pulloor, Sajith Nair, Kathleen McCaffrey, Aleksandar D Kostic, Pradeep Bist, Jeremy D Weaver, Andrew M Riley, Richa Tyagi, Pradeep D Uchil, John D York, Solomon H Snyder, Adolfo García-Sastre, Barry V L Potter, Rongtuan Lin, Stephen B Shears, Ramnik J Xavier, Manoj N Krishnan
Publikováno v:
PLoS Pathogens, Vol 10, Iss 2, p e1003981 (2014)
The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 novel regulatory proteins of
Externí odkaz:
https://doaj.org/article/f96658edd07f4b1fb196fa2464f3ef81
Autor:
Xingyao Li, Regan B. Kirkpatrick, Xiaodong Wang, Charles J. Tucker, Anuj Shukla, Henning J. Jessen, Huanchen Wang, Stephen B. Shears, Chunfang Gu
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114316- (2024)
Summary: Phosphate (Pi) serves countless metabolic pathways and is involved in macromolecule synthesis, energy storage, cellular signaling, and bone maintenance. Herein, we describe the coordination of Pi uptake and efflux pathways to maintain mammal
Externí odkaz:
https://doaj.org/article/f3b6e793e06f4a21a4aaa698b4a545cf
Autor:
Huanchen Wang, Lalith Perera, Nikolaus Jork, Guangning Zong, Andrew M. Riley, Barry V. L. Potter, Henning J. Jessen, Stephen B. Shears
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Inositol pyrophosphates (PP-IPs) regulate immunity and phosphate homeostasis. Here, the authors’ structural dissection of an Arabidopsis thaliana PP-IP phosphatase reveals that substrates drive their own hydrolysis and identifies a highly elusive m
Externí odkaz:
https://doaj.org/article/80727188fe0e4b42b9d3d714ec578029
Autor:
Jia Yu, Barbara Leibiger, Shao-Nian Yang, Stephen B. Shears, Ingo B. Leibiger, Per-Olof Berggren, Christopher J. Barker
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 885 (2023)
Multiple inositol polyphosphate phosphatase (MINPP1) is an enigmatic enzyme that is responsible for the metabolism of inositol hexakisphosphate (InsP6) and inositol 1,3,4,5,6 pentakisphosphate (Ins(1,3,4,5,6)P5 in mammalian cells, despite being restr
Externí odkaz:
https://doaj.org/article/6ffb397ad7494abf9d89ea895e39da7c
Autor:
Soumyadip Sahu, Jacob Gordon, Chunfang Gu, Mack Sobhany, Dorothea Fiedler, Robin E. Stanley, Stephen B. Shears
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 153 (2023)
Inositol pyrophosphates (PP-InsPs); are a functionally diverse family of eukaryotic molecules that deploy a highly-specialized array of phosphate groups as a combinatorial cell-signaling code. One reductive strategy to derive a molecular-level unders
Externí odkaz:
https://doaj.org/article/cdac5d5e38e7480aa0830c4af3bf7ffa
Autor:
Yubai Zhou, Sandip Mukherjee, Daowei Huang, Molee Chakraborty, Chunfang Gu, Guangning Zong, Michael A. Stashko, Kenneth H. Pearce, Stephen B. Shears, Anutosh Chakraborty, Huanchen Wang, Xiaodong Wang
Publikováno v:
J Med Chem
Obesity and obesity-induced metabolic dysfunctions are significant risk factors for nonalcoholic fatty liver disease and cardiovascular diseases. Thus, obesity is an economic and social burden in developed countries. Blocking the synthesis of inosito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd18436005877b78c4cc91e737f70a50
https://doi.org/10.1021/acs.jmedchem.2c00220
https://doi.org/10.1021/acs.jmedchem.2c00220