Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Stephen B Gauld"'
Autor:
Ian D. Odell, Holly Steach, Stephen B. Gauld, Lauren Reinke-Breen, Jozsef Karman, Tracy L. Carr, Joseph B. Wetter, Lucy Phillips, Monique Hinchcliff, Richard A. Flavell
Publikováno v:
Sci Immunol
Immune cells are fundamental regulators of extracellular matrix (ECM) production by fibroblasts and have important roles in determining extent of fibrosis in response to inflammation. Although much is known about fibroblast signaling in fibrosis, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddecce5f56bc5a2499be2aafe69a23d
https://europepmc.org/articles/PMC9840167/
https://europepmc.org/articles/PMC9840167/
Autor:
Geertruida Veldman, Christine Nelson, Robert Dunstan, Fei Wu, Qi Wan, Zhi Su, Marian T. Namovic, Laura Leys, Li Zhou, Richard McCarthy, Gary Overmeyer, Jun Zhang, Stephen B. Gauld, Leyu Wang, Jeffrey Barbon, Susan V. Westmoreland, Yibing Wang, Mark Konrad, Rui Zhu, Denise Perron
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Four antibodies that inhibit interleukin (IL)-23 are approved for the treatment of moderate-to-severe plaque psoriasis. Here, we present non-clinical data comparing ustekinumab, guselkumab, tildrakizumab and risankizumab with regard to thermostabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4575781a8e40df4d55178f079ed23759
http://europepmc.org/articles/PMC8409790
http://europepmc.org/articles/PMC8409790
Autor:
Arun Kannan, Loren M. Lasko, S.E. Paulsboe, Stephen B. Gauld, Zhi Su, Donna Gauvin, Ryan Duggan, Steve McGaraughty, Victoria E. Scott, Michael E. Kort, P. Honore
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports
Foxp3+ regulatory T cells (Tregs) represent a major fraction of skin resident T cells. Although normally protective, Tregs have been shown to produce pro-inflammatory cytokines in human diseases, including psoriasis. A significant hurdle in the Treg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b60dfb852c8a181888be2e0ee179fc5
http://link.springer.com/article/10.1038/s41598-019-53240-z
http://link.springer.com/article/10.1038/s41598-019-53240-z
Autor:
K. Salte, Yibing Wang, Zhi Su, Steve McGaraughty, Joe Wetter, Laura Leys, Rebecca M. Edelmayer, P. Honore, S.E. Paulsboe, Victoria E. Scott, Stephen B. Gauld, Donna Gauvin, Isaac Weinberg, Marian Namovic
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Psoriasis is an immune-mediated inflammatory skin disease that affects millions worldwide. Studying immune cells involved in psoriasis pathogenesis is essential to identify effective and safe therapeutics for the disease. Using human psoriasis skin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86e2581f30b8aa37341c250654437c4
http://link.springer.com/article/10.1038/s41598-019-41655-7
http://link.springer.com/article/10.1038/s41598-019-41655-7
Autor:
S. Huang, Donna Gauvin, Stephen B. Gauld, S.E. Paulsboe, P. Honore, Zheng Liu, Yibing Wang, Rebecca M. Edelmayer, Lauren Olson, K. Salte, S. McGaraughty, Laura Leys, J. Wetter
Publikováno v:
Journal of Dermatological Science. 92:45-53
Background Animal models of Psoriasis (PsO) are important for our understanding of the pathophysiology of human disease but rarely manifest all features of the disease. In order to facilitate greater understanding of the underlying biology of PsO it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208e54bbbdda7377fc0506001a30bf0d
https://doi.org/10.1016/j.jdermsci.2018.08.001
https://doi.org/10.1016/j.jdermsci.2018.08.001
Autor:
Nancy Elms, Katherine A. Gonzaga, John M. Routes, Mary Hintermeyer, Stephen B. Gauld, James W. Verbsky, Mary T. Bausch-Jurken
Publikováno v:
Journal of Clinical Immunology. 37:427-433
The specific antibody response to the unconjugated 23-valent pneumococcal polysaccharide vaccine is one of the most common tests used to assess for possible humoral immunodeficiency. The results can be difficult to interpret because most people have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d823dceb1c26dab9e4f64528835a61
https://doi.org/10.1007/s10875-017-0406-6
https://doi.org/10.1007/s10875-017-0406-6
Autor:
Richard McCarthy, Rebecca M. Edelmayer, Maria A. Argiriadi, Didier Bressac, Craig Wallace, Michael E. Kort, Yibing Wang, Laura Leys, Eric C. Breinlinger, J. Wetter, Zhi Su, Jean-Michel Luccarini, P. Honore, K. Salte, Philippe Masson, Christian Goess, Stephen B. Gauld, Kevin P. Cusack, Donna Gauvin, S. Huang, Dominique Potin, Sébastien Jacquet, S. McGaraughty, Kelly E. Desino
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 371(1)
Blockade of interleukin (IL)-23 or IL-17 with biologics is clinically validated as a treatment of psoriasis. However, the clinical impact of targeting other nodes within the IL-23/IL-17 pathway, especially with small molecules, is less defined. We re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034e971e80621670c1cc818c78451615
https://pubmed.ncbi.nlm.nih.gov/31375639
https://pubmed.ncbi.nlm.nih.gov/31375639
Autor:
S.E. Paulsboe, Peter F. Slivka, J. Wetter, Eric R. Goedken, Marian Namovic, Stephen B. Gauld, Alex Lipovsky, Donna Gauvin, Yibing Wang, Zhi Su, Denise Perron, S. McGaraughty
Publikováno v:
Journal of Investigative Dermatology. 141:1772-1779.e6
Psoriasis is a debilitating skin disease characterized by epidermal thickening, abnormal keratinocyte differentiation, and proinflammatory immune cell infiltrate into the affected skin. IL-17A plays a critical role in the etiology of psoriasis. ACT1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14694a3b78a1f4ae06b7d28f8434c10c
https://doi.org/10.1016/j.jid.2020.10.029
https://doi.org/10.1016/j.jid.2020.10.029
Autor:
Stephen B. Gauld, Eric R. Goedken, S.E. Paulsboe, Peter F. Slivka, Yibing Wang, Alex Lipovsky, J. Wetter, Donna Gauvin, Zhi Su, S. McGaraughty, Marian Namovic
Publikováno v:
Journal of Investigative Dermatology. 139:S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3c98ffee7262c254bea55c3a5e51f90
https://doi.org/10.1016/j.jid.2019.03.091
https://doi.org/10.1016/j.jid.2019.03.091
Autor:
Steven M. Leonardo, Weston Maier, Stephen B. Gauld, Jessica L. De Santis, Jennifer A. McGraw, Joseph M. Kulinski, Elizabeth A. Ruder, Vera L. Tarakanova
Publikováno v:
Immunology. 139:197-204
Viruses such as Epstein–Barr virus (EBV) have been linked to mechanisms that support autoantibody production in diseases such as systemic lupus erythematosus. However, the mechanisms by which viruses contribute to autoantibody production remain poo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990afffed16f041d9e2cede5d5a2049d
https://doi.org/10.1111/imm.12069
https://doi.org/10.1111/imm.12069