Zobrazeno 1 - 10
of 1 291
pro vyhledávání: '"Stephen B Dunnett"'
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164072 (2016)
Huntington's disease (HD) is characterised by motor symptoms which are often preceded by cognitive and behavioural changes, that can significantly contribute to disease burden for people living with HD. Numerous knock-in mouse models of HD are curren
Externí odkaz:
https://doaj.org/article/5b65a3e257f6492ba70a04227f8437f5
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165069 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0144864.].
Externí odkaz:
https://doaj.org/article/1478b76bfe0444b0a7bfc03d3192884f
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155834 (2016)
Huntington's disease (HD) cellular pathology is characterised by the aggregation of mutant huntingtin (mHTT) protein into inclusion bodies. The present paper compared the sensitivity of five widely used mHTT antibodies (S830; MW8; EM48; 1C2; ubiquiti
Externí odkaz:
https://doaj.org/article/84fb407f795d40719c3a02afabfe524f
Publikováno v:
Neuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 5, Pp 835-845 (2008)
Emma L Lane, Olivia J Handley, Anne E Rosser, Stephen B DunnettBrain Repair Group, School of Biosciences, Cardiff University, CF10 3US, UKAbstract: Parkinson’s disease is most commonly treated with a range of pharmacotherapeutics, with the more rec
Externí odkaz:
https://doaj.org/article/a79f5795c2314fd9bdecf5715ff4e6b8
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144864 (2015)
Huntington's disease is a neurodegenerative disorder characterised primarily by motor abnormalities, and is caused by an expanded polyglutamine repeat in the huntingtin protein. Huntingtin dynamically shuttles between subcellular compartments, and th
Externí odkaz:
https://doaj.org/article/ef3d2d24f256400bbd90ad32587a18a0
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Dopamine transmission has been implicated in motor and cognitive function. In Parkinson’s disease (PD), dopamine replacement using the precursor drug l-DOPA is the predominant treatment approach, but long-term exposure leads to the onset o
Externí odkaz:
https://doaj.org/article/cfff42f7ea5e4e1ab38d4f5ab4bbf112
Autor:
Daniel, Rees, Amy L, Beynon, Mariah J, Lelos, Gaynor A, Smith, Luke D, Roberts, Lyndsey, Phelps, Stephen B, Dunnett, Alwena H, Morgan, Rowan M, Brown, Timothy, Wells, Jeffrey S, Davies
Publikováno v:
Cellular and molecular neurobiology.
The feeding-related hormone, acyl-ghrelin, protects dopamine neurones in murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-based models of experimental Parkinson's disease (PD). However, the potential protective effect of acyl-ghrelin on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80c6d669b430079c54c9da5588e12d64
https://pubmed.ncbi.nlm.nih.gov/36107359
https://pubmed.ncbi.nlm.nih.gov/36107359
Autor:
Stephen B. Dunnett, Anne E. Rosser
Publikováno v:
Neurobiology of Disease, Vol 61, Iss , Pp 79-89 (2014)
We review the first generations of clinical trials of novel cell therapies applied to a range of neurodegenerative diseases in the context of mechanisms of functional efficacy. This in turn helps to determine the best strategies to be adopted and the
Externí odkaz:
https://doaj.org/article/a474849214134bc2ae7c62e7f3f2545d
Publikováno v:
Neurobiology of Disease, Vol 50, Iss , Pp 142-150 (2013)
Abnormal involuntary movement (AIM) rating scales are frequently used to study the mechanisms underlying l-DOPA-induced dyskinesia (LID) in 6-OHDA lesioned rodents and the propensity of novel treatments for Parkinson's disease to induce or alleviate
Externí odkaz:
https://doaj.org/article/4fb7ba2ad14546da904a99aa1343a12a
Autor:
Daniel Rees, Amy L. Beynon, Mariah J. Lelos, Gaynor A. Smith, Luke D. Roberts, Lyndsey Phelps, Stephen B. Dunnett, Alwena H. Morgan, Rowan M. Brown, Timothy Wells, Jeffrey S. Davies
The feeding-related hormone, acyl-ghrelin, protects dopamine neurons in murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-based models of experimental Parkinson’s disease (PD). However, the potential protective effect of acyl-ghrelin on su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8256a460abb03791a206464ea5633dc0
https://cronfa.swan.ac.uk/Record/cronfa59475/Download/59475__25351__9a510e4c130f45738d2458f48ed48839.pdf
https://cronfa.swan.ac.uk/Record/cronfa59475/Download/59475__25351__9a510e4c130f45738d2458f48ed48839.pdf
