Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Stephen B, Wheatcroft"'
Autor:
Azhar Maqbool, Hema Viswambharan, Anna Skromna, Natallia Makava, Heba Shawer, Katherine Bridge, Shovkat Kadirovich Muminov, Helen Imrie, Kathryn Griffin, Stephen B Wheatcroft, Piruthivi Sukumar, Richard M Cubbon, Mark T Kearney, Nadira Yusupovna Yuldasheva
Publikováno v:
Vascular Biology, Vol 6, Iss 1, Pp 1-8 (2024)
Insulin resistance underpins the progression of type 2 diabetes mellitus and leads to a collection of risk factors for the development of atherosclerosis. Whether or not insulin resistance at a whole-body level per se leads to accelerated atheroscler
Externí odkaz:
https://doaj.org/article/04b8efb0aafa42a292c29ead35d01c2a
Autor:
Andrew MN Walker, Nicole T. Watt, Nadira Y. Yuldasheva, Sanjush Dalmia, Marcella Conning-Rowland, Chew W. Cheng, Nele Warmke, Katherine Bridge, Oliver I. Brown, Cheukyau Luk, Michael Drozd, Natalie J. Haywood, Anna Skromna, Natasha Makava, Stephen B. Wheatcroft, Mark T. Kearney, Richard M. Cubbon
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e36457- (2024)
Objective: Reduced IGF-1 signalling is an evolutionarily conserved mediator of longevity, yet the magnitude of this effect is substantially larger in organisms retaining a common insulin and IGF-1 receptor. Whether this reflects the failure to simult
Externí odkaz:
https://doaj.org/article/8e31cd24581c4d399766217804bdc0d5
Autor:
Helen Imrie, Hema Viswambharan, Natalie J Haywood, Katherine I Bridge, Nadira Y Yuldasheva, Stacey Galloway, Katie J Simmons, Richard M Cubbon, Piruthivi Sukumar, Nicole T Watt, Laeticia Lichtenstein, Judy I Wyatt, Hiromi Kudo, Robert Goldin, Baptiste Rode, Stephen B Wheatcroft, Mark T Kearney
Publikováno v:
Adipocyte, Vol 11, Iss 1, Pp 366-378 (2022)
High fat diet (HFD)-induced obesity leads to perturbation in the storage function of white adipose tissue (WAT) resulting in deposition of lipids in tissues ill-equipped to deal with this challenge. The role of insulin like growth factor-1 (IGF-1) in
Externí odkaz:
https://doaj.org/article/3a306229dac84d0493dc86af288e28b8
Autor:
Shane Parfrey, Amr Abdelrahman, Daniel Blackman, Jonathan M. Blaxill, Michael S. Cunnington, John P. Greenwood, Christopher J. Malkin, Abdul M. Mozid, Jennifer A. Rossington, Murugapathy Veerasamy, Nancy Wassef, Stephen B. Wheatcroft, Heerajnarain Bulluck
Publikováno v:
BMC Cardiovascular Disorders, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Very short duration of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) has recently attracted a lot of attention with the introduction of newer generations stents. This is appealing, especially in patients
Externí odkaz:
https://doaj.org/article/53ff4a31117941ec854b814dec536678
Autor:
Rabeia Javid, Thomas A Slater, Robert Bowes, Murugapathy Veerasamy, Nancy Wassef, Jennifer A Rossington, Abdul M Mozid, Ananth Kidambi, Stephen B Wheatcroft, Muzahir H Tayebjee
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281374 (2023)
IntroductionPercutaneous coronary intervention is performed routinely in the management of myocardial infarction with obstructive coronary disease, but intervention to arteries supplying nonviable myocardium may be harmful. It is important therefore
Externí odkaz:
https://doaj.org/article/4553f7f743014209a084e4b493551f7b
Autor:
Daniel J Blackman, John P Greenwood, Paul D Baxter, Christopher J Malkin, Arvindra Krishnamurthy, Michelle Anderson, Kathryn Somers, Natalie Burton-Wood, Charlotte Harland, Jonathan M Blaxill, Stephen B Wheatcroft, Claire M Keeble, Jim M McLenachan
Publikováno v:
Open Heart, Vol 9, Iss 2 (2022)
Background There is a paucity of real-world data assessing the association of operator volumes and mortality specific to primary percutaneous coronary intervention (PPCI).Methods Demographic, clinical and outcome data for all patients undergoing PPCI
Externí odkaz:
https://doaj.org/article/88faa8a271724c2996c5084704d60c6f
Autor:
Hansa Iqbal, Sam Straw, Thomas P. Craven, Katherine Stirling, Stephen B. Wheatcroft, Klaus K. Witte
Publikováno v:
ESC Heart Failure, Vol 7, Iss 5, Pp 2032-2041 (2020)
Abstract Aims Left ventricular (LV) thrombus is increasingly detected in patients with and without ischaemic heart disease due to the increased availability of cardiac magnetic resonance imaging. Risk factors include anterior ST elevation myocardial
Externí odkaz:
https://doaj.org/article/ece46dd43fde45bea74cbd3669e9f313
Autor:
Talia Caspi, Sam Straw, Chew Cheng, Jack O Garnham, Jason L. Scragg, Jessica Smith, Aaron O. Koshy, Eylem Levelt, Piruthivi Sukumar, John Gierula, David J. Beech, Mark T. Kearney, Richard M. Cubbon, Stephen B. Wheatcroft, Klaus K. Witte, Lee D. Roberts, T. Scott Bowen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 18 (2020)
Background People with chronic heart failure (CHF) experience severe skeletal muscle dysfunction, characterized by mitochondrial abnormalities, which exacerbates the primary symptom of exercise intolerance. However, the molecular triggers and charact
Externí odkaz:
https://doaj.org/article/77f1fe2c40ff4e25b5657d33ba7106ee
Autor:
Gina A. Smith, Gareth W. Fearnley, Izma Abdul-Zani, Stephen B. Wheatcroft, Darren C. Tomlinson, Michael A. Harrison, Sreenivasan Ponnambalam
Publikováno v:
Biology Open, Vol 6, Iss 10, Pp 1404-1415 (2017)
Cell surface receptors can undergo recycling or proteolysis but the cellular decision-making events that sort between these pathways remain poorly defined. Vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor
Externí odkaz:
https://doaj.org/article/0083afd86eff426b9d979f5c7df686ce
Autor:
Baptiste Rode, Jian Shi, Naima Endesh, Mark J. Drinkhill, Peter J. Webster, Sabine J. Lotteau, Marc A. Bailey, Nadira Y. Yuldasheva, Melanie J. Ludlow, Richard M. Cubbon, Jing Li, T. Simon Futers, Lara Morley, Hannah J. Gaunt, Katarzyna Marszalek, Hema Viswambharan, Kevin Cuthbertson, Paul D. Baxter, Richard Foster, Piruthivi Sukumar, Andrew Weightman, Sarah C. Calaghan, Stephen B. Wheatcroft, Mark T. Kearney, David J. Beech
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The mechanisms that regulate the body’s response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial
Externí odkaz:
https://doaj.org/article/7f62f67aa840473d94edc1b8db9c890a