Zobrazeno 1 - 10
of 294
pro vyhledávání: '"Stephen B, Liggett"'
Autor:
Adley Gin, Phuong-Diem Nguyen, Jeffrey E. Melzer, Cheng Li, Hannah Strzelinski, Stephen B. Liggett, Judith Su
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract G-protein coupled receptors help regulate cellular function and communication, and are targets of small molecule drug discovery efforts. Conventional techniques to probe these interactions require labels and large amounts of receptor to achi
Externí odkaz:
https://doaj.org/article/249d1c6b0f6c41e9896245694f75acef
Autor:
Robert J. Lefkowitz, Howard A. Rockman, Paul J. Shim, Samuel Liu, Seungkirl Ahn, Biswaranjan Pani, Sudarshan Rajagopal, Sudha K. Shenoy, Michel Bouvier, Jeffrey L. Benovic, Stephen B. Liggett, Robert R. Ruffolo, Michael R. Bristow, Milton Packer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/1516c52dd4af4fd98dff325b5997c3e9
Autor:
Philip D. Tatman, David P. Kao, Kathryn C. Chatfield, Ian A. Carroll, Jessica A. Wagner, Eric R. Jonas, Carmen C. Sucharov, J. David Port, Brian D. Lowes, Wayne A. Minobe, Sophia P. Huebler, Anis Karimpour-Fard, Erin M. Rodriguez, Stephen B. Liggett, Michael R. Bristow
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
We investigated the extent, biologic characterization, phenotypic specificity, and possible regulation of a β1-adrenergic receptor–linked (β1-AR–linked) gene signaling network (β1-GSN) involved in left ventricular (LV) eccentric pathologic rem
Externí odkaz:
https://doaj.org/article/cc7c56d0fed841659469accaddf4f47a
Autor:
Jung-A. A. Woo, Tian Liu, Cenxiao C. Fang, Sara Cazzaro, Teresa Kee, Patrick LePochat, Ksenia Yrigoin, Courtney Penn, Xingyu Zhao, Xinming Wang, Stephen B. Liggett, David E. Kang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/53eb33bef2334933a0bf4a285008e1ab
Autor:
Alina Tokmakova, Donghwa Kim, Brian Guthrie, Soo-Kyung Kim, William A. Goddard, III, Stephen B. Liggett
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106422- (2023)
Summary: The 25 human bitter taste receptors (TAS2Rs) are expressed on taste and extra-oral cells representing an integrated chemosensory system. The archetypal TAS2R14 is activated by > 150 topographically diverse agonists, raising the question of h
Externí odkaz:
https://doaj.org/article/382ca3127a474918bc78e67811c5bada
Autor:
Jung-A A. Woo, Maria Castaño, Teresa R. Kee, Jordan Lee, Cynthia J. Koziol-White, Steven S. An, Donghwa Kim, David E. Kang, Stephen B. Liggett
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 68:417-429
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8ac9c1be88c474401eaf3a42bb9f96b
https://doi.org/10.1165/rcmb.2022-0303oc
https://doi.org/10.1165/rcmb.2022-0303oc
Autor:
Donghwa Kim, Alina Tokmakova, Jung-A A. Woo, Steven S. An, William A. Goddard, Stephen B. Liggett
G protein coupled receptors (GPCRs) are a superfamily of transmembrane-spanning receptors that are activated by multiple endogenous ligands and are the most common target for agonist or antagonist therapeutics across a broad spectrum of diseases. Ini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e379f92b40736a420987b735b40411
https://resolver.caltech.edu/CaltechAUTHORS:20220523-164626000
https://resolver.caltech.edu/CaltechAUTHORS:20220523-164626000
Autor:
Garrett A, Enten, Xianlong, Gao, Hannah R, Strzelinski, McWayne, Weche, Stephen B, Liggett, Matthias, Majetschak
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(20)
It is known that catecholamines regulate innate immune functions. The underlying mechanisms, however, are not well understood. Here we show that at least 20 members of the human chemokine receptor (CR) family heteromerize with one or more members of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66471a7579c27ec885dfbc655e10db74
https://pubmed.ncbi.nlm.nih.gov/35537053
https://pubmed.ncbi.nlm.nih.gov/35537053
Autor:
Garrett A. Enten, Xianlong Gao, Hannah R. Strzelinski, McWayne Weche, Stephen B. Liggett, Matthias Majetschak
Publikováno v:
Proceedings of the National Academy of Sciences. 119
SignificanceHere we show that most chemokine receptors (CRs) form heteromeric complexes with α1-adrenergic receptors (ARs) in recombinant systems and that such heteromers are detectable in human monocytes and in the human monocytic leukemia cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::598b9fbae52c66e5d7d337ef3885588d
https://doi.org/10.1073/pnas.2123511119
https://doi.org/10.1073/pnas.2123511119
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Bitter taste receptors (TAS2Rs) are recognized as being expressed on multiple cell types and organs, including human airway smooth muscle (HASM) cells, where agonists promote significant relaxation to constrictive stimuli. Thus, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b2578fa1a5065711a9e30948c58c43
https://doi.org/10.1021/acsptsci.0c00127
https://doi.org/10.1021/acsptsci.0c00127