Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Stephen Arkle"'
Autor:
Rasha Al-Khalidi, Chiara Panicucci, Paul Cox, Natalia Chira, Justyna Róg, Christopher N. J. Young, Rhiannon E. McGeehan, Kameshwari Ambati, Jayakrishna Ambati, Krzysztof Zabłocki, Elisabetta Gazzerro, Stephen Arkle, Claudio Bruno, Dariusz C. Górecki
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Duchenne muscular dystrophy (DMD) is the most common inherited muscle disorder that causes severe disability and death of young men. This disease is characterized by progressive muscle degeneration aggravated by sterile inflammation and is a
Externí odkaz:
https://doaj.org/article/dd25d786045a4ae7b7f3c0189e811271
Autor:
Anthony Sinadinos, Christopher N J Young, Rasha Al-Khalidi, Anna Teti, Paweł Kalinski, Shafini Mohamad, Léonore Floriot, Tiphaine Henry, Gianluca Tozzi, Taiwen Jiang, Olivier Wurtz, Alexis Lefebvre, Mikhail Shugay, Jie Tong, David Vaudry, Stephen Arkle, Jean-Claude doRego, Dariusz C Górecki
Publikováno v:
PLoS Medicine, Vol 12, Iss 10, p e1001888 (2015)
BackgroundDuchenne muscular dystrophy (DMD) is the most common inherited muscle disease, leading to severe disability and death in young men. Death is caused by the progressive degeneration of striated muscles aggravated by sterile inflammation. The
Externí odkaz:
https://doaj.org/article/2382264224b74bba97356135e450e25b
Publikováno v:
Archives of Biochemistry and Biophysics. 457:105-110
This study reports that dexamethasone (DEX) significantly induces CYP3A11, CYP3A13 and CYP3A25 mRNA expression in male and female 4 days, 3 weeks and 18 weeks old C57BL/6J mice. Furthermore, CYP3A activity, as measured by erythromycin-N-demethylation
Autor:
Stephen Arkle, Dariusz C. Górecki, David Vaudry, Alexis Lefebvre, Christopher N. J. Young, Philippe Chan, Anthony Sinadinos
Publikováno v:
Young, C, Sinadinos, A, Lefebvre, A, Chan, P, Arkle, S, Vaudry, D & Gorecki, D 2015, ' A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90 ', Autophagy, vol. 11, no. 1, pp. 113-130 . https://doi.org/10.4161/15548627.2014.994402
Autophagy
Autophagy
P2RX7 is an ATP-gated ion channel, which can also exhibit an open state with a considerably wider permeation. However, the functional significance of the movement of molecules through the large pore (LP) and the intracellular signaling events involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f70b158d516f117b614c75ea744b74
https://doi.org/10.4161/15548627.2014.994402
https://doi.org/10.4161/15548627.2014.994402
Autor:
Marta Onopiuk, Christopher N. J. Young, Wojciech Brutkowski, Justyna Róg, Sylwia Wojciechowska, Dariusz C. Górecki, Stephen Arkle, Elżbieta Krasowska, Krzysztof Zabłocki, Morten Ritso
Publikováno v:
Onopiuk, M, Brutkowski, W, Young, C, Krasowska, E, Rog, J, Ritso, M, Wojciechowska, S, Arkle, S, Zablocki, K & Gorecki, D C 2015, ' Store-operated calcium entry contributes to abnormal Ca 2+ signalling in dystrophic mdx mouse myoblasts ', Archives of Biochemistry and Biophysics, vol. 569, pp. 1-9 . https://doi.org/10.1016/j.abb.2015.01.025
Sarcolemma damage and activation of various calcium channels are implicated in altered Ca2+ homeostasis in muscle fibres of both Duchenne muscular dystrophy (DMD) sufferers and in the mdx mouse model of DMD. Previously we have demonstrated that also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbe796855b39cba52023a8e409fab15
http://hdl.handle.net/2086/15031
http://hdl.handle.net/2086/15031
Autor:
Marta, Onopiuk, Wojciech, Brutkowski, Christopher, Young, Elżbieta, Krasowska, Justyna, Róg, Morten, Ritso, Sylwia, Wojciechowska, Stephen, Arkle, Krzysztof, Zabłocki, Dariusz C, Górecki
Publikováno v:
Archives of biochemistry and biophysics. 569
Sarcolemma damage and activation of various calcium channels are implicated in altered Ca(2+) homeostasis in muscle fibres of both Duchenne muscular dystrophy (DMD) sufferers and in the mdx mouse model of DMD. Previously we have demonstrated that als
Autor:
Dariusz C. Górecki, Chun-Fu Lien, Stephen Arkle, Christopher N. J. Young, Hanns Lochmüller, Wojciech Brutkowski, Krzysztof Zabłocki
Publikováno v:
Journal of Cellular and Molecular Medicine
Duchenne muscular dystrophy (DMD) is a lethal inherited muscle disorder. Pathological characteristics of DMD skeletal muscles include, among others, abnormal Ca2+ homeostasis and cell signalling. Here, in the mdx mouse model of DMD, we demonstrate si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0dca5b0c0796bddd27f109bc724c99
http://hdl.handle.net/2086/15030
http://hdl.handle.net/2086/15030
Publikováno v:
Journal of Experimental Biology. 184:63-88
Medullary bone forms in egg-laying birds in response to gonadal steroids and is the most overtly oestrogen-dependent of all bone types. It acts as a labile reservoir for the supply of eggshell calcium. Previous studies indicate that feeding calcium-
Autor:
Eric A. Barnard, Stephen Arkle, Taiwen Jiang, Krzysztof Zabłocki, Davy Yeung, Hanns Lochmüller, Joseph Simon, Chun-Fu Lien, Wojciech Brutkowski, Dariusz C. Górecki, James Brown
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20(6)
Pathological cellular hallmarks of Duchenne muscular dystrophy (DMD) include, among others, abnormal calcium homeostasis. Changes in the expression of specific receptors for extracellular ATP in dystrophic muscle have been recently documented: here,
Publikováno v:
Autonomicautacoid pharmacology. 25(3)
1. Experiments were carried out to characterize the possible adrenergic properties of the 5-HT(1A) antagonists WAY 100635 and MM-77 using the mouse isolated vasa deferentia preparation. 2. When vasa deferentia were preincubated for 10 min in the pres