Výsledky vyhledávání - "Stephen Archacki"

Akademický článek

Statistical and Functional Studies Identify Epistasis of Cardiovascular Risk Genomic Variants From Genome‐Wide Association Studies

Autor: Yabo Li, Hyosuk Cho, Fan Wang, Oriol Canela‐Xandri, Chunyan Luo, Konrad Rawlik, Stephen Archacki, Chengqi Xu, Albert Tenesa, Qiuyun Chen, Qing Kenneth Wang

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 7 (2020)

Background Epistasis describes how gene‐gene interactions affect phenotypes, and could have a profound impact on human diseases such as coronary artery disease (CAD). The goal of this study was to identify gene‐gene interactions in CAD using an e

Externí odkaz: https://doaj.org/article/0a3445cba489428884a3a35fe867f338

Zobrazit plný text záznamu

Long noncoding RNA ANRIL regulates endothelial cell activities associated with coronary artery disease by up-regulating CLIP1, EZR, and LYVE1 genes

Autor: Qing Kenneth Wang, Qiuyun Chen, Gang Yu, Gong-Qing Shen, Xiaofeng Wang, Susmita Chakrabarti, Hyosuk Cho, Fan Wang, Yabo Li, Stephen Archacki

Publikováno v: Journal of Biological Chemistry. 294:3881-3898

Coronary artery disease (CAD) is the leading cause of death worldwide. Long noncoding RNAs (lncRNAs) are a class of noncoding transcripts of > 200 nucleotides and are increasingly recognized as playing functional roles in physiology and disease. ANRI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e62f9ea0b1527b0c580eee180c568d7
https://doi.org/10.1074/jbc.ra118.005050

Zobrazit plný text záznamu

Role of epigenetic m6A RNA methylation in vascular development:mettl3regulates vascular development through PHLPP2/mTOR‐AKT signaling

Autor: Stephen Archacki, Hui Li, Isabel Z. Wang, Chengqi Xu, Qiuyun Chen, Ramendu Parial, Jia Li, Qing Kenneth Wang, Zhongcheng Yang

Publikováno v: The FASEB Journal. 35

N6 -methyladenosine (m6A) methylation is the most prevalent RNA modification, and it emerges as an important regulatory mechanism of gene expression involved in many cellular and biological processes. However, the role of m6 A methylation in vascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f182a167f99ffc7e2d208c1509be48a
https://doi.org/10.1096/fj.202000516rr

Zobrazit plný text záznamu

Role of epigenetic m

Autor: Ramendu, Parial, Hui, Li, Jia, Li, Stephen, Archacki, Zhongcheng, Yang, Isabel Z, Wang, Qiuyun, Chen, Chengqi, Xu, Qing K, Wang

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd20e4dc2224e44198d275ce51acf9ae
https://pubmed.ncbi.nlm.nih.gov/33788967

Zobrazit plný text záznamu

Splice variants of lncRNA RNA ANRIL exert opposing effects on endothelial cell activities associated with coronary artery disease

Autor: Gang Yu, Susmita Chakrabarti, Qiuyun Chen, Yang Guo, Qing Kenneth Wang, Hyosuk Cho, Fan Wang, Yabo Li, Stephen Archacki

Publikováno v: RNA Biol

Each gene typically has multiple alternatively spliced transcripts. Different transcripts are assumed to play a similar biological role; however, some transcripts may simply lose their function due to loss of important functional domains. Here, we sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad0fed7af55653bb354c963cb46d4e2
https://europepmc.org/articles/PMC7549722/

Zobrazit plný text záznamu

Statistical and Functional Studies Identify Epistasis of Cardiovascular Risk Genomic Variants From Genome-Wide Association Studies

Autor: Qing Kenneth Wang, Fan Wang, Oriol Canela-Xandri, Yabo Li, Hyosuk Cho, Albert Tenesa, Konrad Rawlik, Stephen Archacki, Chengqi Xu, Qiuyun Chen, Chunyan Luo

Publikováno v: Li, Y, Cho, H, Wang, F, Canela-Xandri, O, Luo, C, Rawlik, K, Archacki, S, Xu, C, Tenesa, A, Chen, Q & Wang, Q K 2020, ' Statistical and Functional Studies Identify Epistasis of Cardiovascular Risk Genomic Variants From Genome-Wide Association Studies ', Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, vol. 9, no. 7, pp. e014146 . https://doi.org/10.1161/JAHA.119.014146
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background Epistasis describes how gene‐gene interactions affect phenotypes, and could have a profound impact on human diseases such as coronary artery disease ( CAD ). The goal of this study was to identify gene‐gene interactions in CAD using an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f16c1d30fdeb7d03a7c42eda152a18
https://www.pure.ed.ac.uk/ws/files/143823994/Statistical_and_Functional_Studies_Identify_Epistasis_of_Cardiovascular_Risk_Genomic_Variants_From_Genome_Wide_Association_Studies.html

Zobrazit plný text záznamu

Identification of three mutations in the MVK gene in six patients associated with disseminated superficial actinic porokeratosis

Autor: Ying Liu, Mugen Liu, Juanjuan Ma, Jiuxiang Wang, Yayun Qin, Changzheng Huang, Stephen Archacki, Duanzuo Li

Publikováno v: Clinica Chimica Acta. 454:124-129

Porokeratosis is recognized as a heterogenously inherited epidermal keratinization disorder. Disseminated superficial actinic porokeratosis (DSAP) is considered to be the most common form of porokeratosis and is characterized by multiple, small kerat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f181fe3dbca7d65a918bdab8d5e1dda
https://doi.org/10.1016/j.cca.2016.01.009

Zobrazit plný text záznamu

ADTRP regulates TFPI expression via transcription factor POU1F1 involved in coronary artery disease

Publikováno v: Gene. 753:144805

Genomic variants in both ADTRP and TFPI genes are associated with risk of coronary artery disease (CAD). ADTRP regulates TFPI expression and endothelial cell functions involved in the initiation of atherosclerotic CAD. ADTRP also specifies primitive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07814fd4da75b6aa9c943632b8d48395
https://doi.org/10.1016/j.gene.2020.144805

Zobrazit plný text záznamu

Knockout of ush2a gene in zebrafish causes hearing impairment and late onset rod-cone dystrophy

Publikováno v: Human genetics. 137(10)

Most cases of Usher syndrome type II (USH2) are due to mutations in the USH2A gene. There are no effective treatments or ideal animal models for this disease, and the pathological mechanisms of USH2 caused by USH2A mutations are still unknown. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d039f72bd7f81137af8eb33d6b1b1a
https://pubmed.ncbi.nlm.nih.gov/30242501

Zobrazit plný text záznamu

Analysis of causal effect of APOA5 variants on premature coronary artery disease

Autor: Eric J. Topol, Carlos A. Hubbard, Stephen G. Ellis, Qiuyun Chen, John Barnard, Fan Wang, Isabel Z. Wang, Stephen Archacki, Qing Kenneth Wang

Publikováno v: Annals of human genetics. 82(6)

Apolipoprotein A5 (APOA5) regulates the metabolisms of triglyceride and HDL. APOA5 variants have been linked to coronary artery disease (CAD), but their causal roles are not well studied yet. This study aims to identify the causal effects of APOA5 va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2574664411835f62d5a94f7ecfeaf67
https://pubmed.ncbi.nlm.nih.gov/30024021

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání