Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Stephen Altmann"'
Autor:
Kristin Taborn, Joseph Ligutti, Josie H. Lee, Thomas Kornecook, Dong Liu, Dawn Zhu, Stephen Altmann, Ruoyuan Yin, Xuhai Be, Robert T. Fremeau, Jinti Wang, John Roberts, David J. Matson, Danielle Johnson, Violeta Yu, Christopher P Ilch, Bryan D. Moyer, Jason A. Luther, Virginia Berry, Matthew Weiss, Danny Ortuno, Michael Jarosh, Sonya G. Lehto
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 362:146-160
Potent and selective antagonists of the voltage-gated sodium channel NaV1.7 represent a promising avenue for the development of new chronic pain therapies. We generated a small molecule atropisomer quinolone sulfonamide antagonist AMG8379 and a less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d863f2d2c28cbf4708d06dfd96734ade
https://doi.org/10.1124/jpet.116.239590
https://doi.org/10.1124/jpet.116.239590
Autor:
Robert T. Fremeau, Joseph Ligutti, Paul E. Rose, Dong Liu, Elma Feric Bojic, Yan Wang, Hongbing Huang, Violeta Yu, Thomas Kornecook, Angel Guzman-Perez, Laurie B. Schenkel, Hakan Gunaydin, Stephen Altmann, Jean Wang, Kristin Taborn, Matthew Weiss, Margaret Y. Chu-Moyer, Michael Jarosh, Howard Bregman, Hua Gao, Robert S. Foti, Bryan D. Moyer, Brian E. Hall, Loren Berry, Nagasree Chakka, Josie Lee, Daniel Ortuno, Erin F. DiMauro
Publikováno v:
Journal of medicinal chemistry. 59(17)
The majority of potent and selective hNaV1.7 inhibitors possess common pharmacophoric features that include a heteroaryl sulfonamide headgroup and a lipophilic aromatic tail group. Recently, reports of similar aromatic tail groups in combination with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae84d39f884bb9eb14c6496cd67e32ce
https://pubmed.ncbi.nlm.nih.gov/27441383
https://pubmed.ncbi.nlm.nih.gov/27441383