Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Stephen A.C. Wren"'
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3546-3549
We report what we believe is the first use of 19F NMR spectroscopy to directly measure in-vitro release (IVR) from polymeric nanoparticles (PNPs). Using 19F NMR we selectively measured IVR of AZD2811 from PNPs. Due to rapid nuclear relaxation in soli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::901464db2e5e2d2768db44570cf37f0f
https://doi.org/10.1016/j.xphs.2021.08.011
https://doi.org/10.1016/j.xphs.2021.08.011
Autor:
Leslie P. Hughes, David Whittaker, Jonathan Booth, Stephen A.C. Wren, James F. McCabe, Mick D. Mantle, Elena Pisa
Publikováno v:
Molecular Pharmaceutics. 17:2021-2033
The formulation of drug/polymer amorphous solid dispersions (ASDs) is one of the most successful strategies for improving the oral bioavailability of poorly soluble active pharmaceutical ingredients (APIs). Hot-melt extrusion (HME) is one method for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb6e9d6e122a3ab3007dd7400211c67
https://doi.org/10.1021/acs.molpharmaceut.0c00188
https://doi.org/10.1021/acs.molpharmaceut.0c00188
Publikováno v:
Powder Technology. 341:23-37
In this research the effect of two fundamental stresses, i.e. the tableting load and roller compaction pressure, on tablet disintegration were investigated. Excipient materials were roller compacted using a range of pressures, and tablets were produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b24fadb371a6901d7cb82b79f85a81c
https://doi.org/10.1016/j.powtec.2018.08.065
https://doi.org/10.1016/j.powtec.2018.08.065
Publikováno v:
Journal of pharmaceutical sciences. 109(7)
The measurement of nanoparticle size, and size distribution, is important to the development of pharmaceutical nanoparticle products and their manufacturing processes. In this work we report on the use of 4 widely-used liquid-phase techniques, dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b74a3b841cdd9b7750bc2d1f263199a
https://pubmed.ncbi.nlm.nih.gov/32278922
https://pubmed.ncbi.nlm.nih.gov/32278922
Publikováno v:
Crystal Growth & Design. 17:5108-5116
The dissolution kinetics of individual microscale bicalutamide (BIC) form-I crystals are tracked over time using in situ atomic force microscopy (AFM), with the evolution of crystal morphology used to obtain quantitative data on dissolution kinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddbbb9f71032cb77064a931cc24d3876
https://doi.org/10.1021/acs.cgd.7b00401
https://doi.org/10.1021/acs.cgd.7b00401
Autor:
Leslie P. Hughes, Michael D. Ward, Laura N. Poloni, Maria Adobes-Vidal, Stephen A.C. Wren, Dmitry Momotenko, Faduma M. Maddar, Patrick R. Unwin
Publikováno v:
Crystal Growth & Design. 16:4421-4429
A versatile in situ multi-microscopy approach to study the dissolution kinetics of single crystals is described, using the loop diuretic drug furosemide as a testbed to demonstrate the utility of the approach. Using optical microscopy and scanning io
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af7cb46c834c0bbdd8dd64906ebba3f
https://doi.org/10.1021/acs.cgd.6b00543
https://doi.org/10.1021/acs.cgd.6b00543
Publikováno v:
Rapid Communications in Mass Spectrometry. 29:1107-1114
RATIONALE: A current challenge for analytical chemists is the development of measurement systems and approaches required to understand dynamic processes such as tablet dissolution. The design and development of oral tablets could be improved by the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b882ed5ba0c91c3962d5b165288042f
https://doi.org/10.1002/rcm.7203
https://doi.org/10.1002/rcm.7203
Autor:
Leslie P. Hughes, Francesco Tres, Kevin Treacher, Jonathan C. Burley, Stephen A.C. Wren, Jonathan Booth, Jonathan W. Aylott
Publikováno v:
Molecular pharmaceutics. 13(3)
Because of its weakly acidic nature (pKa of 4.5), indomethacin presents an aqueous solubility that significantly increases when changing from acidic to neutral/alkaline pH (1.5 μg/mL at pH 1.2 and 105.2 μg/mL at pH 7.4). We have therefore investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc07fd36eb5aedec0c013e504c86078
https://pubmed.ncbi.nlm.nih.gov/26845251
https://pubmed.ncbi.nlm.nih.gov/26845251
Autor:
Gavin K. Reynolds, Agba D. Salman, Arthi D. Rajkumar, Michael J. Hounslow, Stephen A.C. Wren, David Wilson
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 106
Tablet disintegration is a fundamental parameter that is tested in vitro before a product is released to the market, to give confidence that the tablet will break up in vivo and that active drug will be available for absorption. Variations in tablet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6b07a4c31d9f0319b29e159ba7c31f
https://pubmed.ncbi.nlm.nih.gov/27287552
https://pubmed.ncbi.nlm.nih.gov/27287552
Autor:
Jamie Patient, Francesco Tres, Stephen A.C. Wren, Leslie P. Hughes, Jonathan C. Burley, Jonathan W. Aylott, Philip M. Williams, Kevin Treacher, Jonathan Booth
Publikováno v:
Molecular pharmaceutics. 12(5)
Real-time in situ Raman mapping has been employed to monitor, during dissolution, the crystallization transitions of amorphous bicalutamide formulated as a molecular dispersion in a copovidone VA64 matrix. The dissolution performance was also investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2322ea644966998236a9ff19f8fcfd6d
https://pubmed.ncbi.nlm.nih.gov/25872658
https://pubmed.ncbi.nlm.nih.gov/25872658