Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Stephen A. Whelan"'
Autor:
Dakota R. Robarts, Steven R. McGreal, David S. Umbaugh, Wendena S. Parkes, Manasi Kotulkar, Sarah Abernathy, Norman Lee, Hartmut Jaeschke, Sumedha Gunewardena, Stephen A. Whelan, John A. Hanover, Natasha E. Zachara, Chad Slawson, Udayan Apte
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1510-1529 (2022)
Background & Aims: The liver has a unique capacity to regenerate after injury in a highly orchestrated and regulated manner. Here, we report that O-GlcNAcylation, an intracellular post-translational modification regulated by 2 enzymes, O-GlcNAc trans
Externí odkaz:
https://doaj.org/article/ea3c4596c6654707b658a0f0be83e403
Autor:
Nkiruka V. Arinze, Wenqing Yin, Saran Lotfollahzadeh, Marc Arthur Napoleon, Sean Richards, Joshua A. Walker, Mostafa Belghasem, Jonathan D. Ravid, Mohamed Hassan Kamel, Stephen A. Whelan, Norman Lee, Jeffrey J. Siracuse, Stephan Anderson, Alik Farber, David Sherr, Jean Francis, Naomi M. Hamburg, Nader Rahimi, Vipul C. Chitalia
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)
Chronic kidney disease (CKD) imposes a strong and independent risk for peripheral artery disease (PAD). While solutes retained in CKD patients (uremic solutes) inflict vascular damage, their role in PAD remains elusive. Here, we show that the dietary
Externí odkaz:
https://doaj.org/article/4ee000486c134e99bdab746f991fce26
Autor:
Andreia eVasconcelos-dos-Santos, Isadora A. Oliveira, Miguel Clodomiro Lucena, Natalia Rodrigues Mantuano, Stephen A. Whelan, Wagner Barbosa Dias, Adriane Regina Todeschini
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the malignant phenotype. The hexosamine biosynthetic pathway (HBP) is a branch of glucose metabolism that produces UDP-GlcNAc, and its derivatives, UDP-GalNAc and CMP-
Externí odkaz:
https://doaj.org/article/35dcb941cd3147b68195bdaf4d17fceb
Autor:
Stephen A. Whelan, Nathan Hendricks, Zachary L. Dwight, Qin Fu, Annie Moradian, Jennifer E. Van Eyk, Susan M. Mockus
SummaryTelehealth, accessing healthcare and wellness remotely, should be a cost effective and efficient way for individuals to receive care. The convenience of having a robust remote collection device for blood tests will facilitate access to precisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f1020b2927f7000fe78ca8c1321410
https://doi.org/10.1101/2023.02.04.23285394
https://doi.org/10.1101/2023.02.04.23285394
Publikováno v:
Foods; Volume 11; Issue 8; Pages: 1163
To standardise research activity and determine alcohol yield from native Irish hard wheat grain, a benchmark approach that reflects Irish industry norms is required. The goal of this study was to optimise milling parameters, grain particle size, and
Publikováno v:
Nucleic Acids Research
Transcription factor decoy binding sites are short DNA sequences that can serve as “sponges” to titrate a transcription factor away from its natural binding site, therefore regulating gene expression. In this study, we harness decoy sites to deve
Autor:
Mohamed Hassan Kamel, Wenqing Yin, Jeffrey J. Siracuse, David H. Sherr, Jonathan D. Ravid, Stephan W. Anderson, Saran Lotfollahzadeh, Vipul C. Chitalia, Stephen A. Whelan, Norman Lee, Nkiruka Arinze, Alik Farber, Joshua Walker, Mostafa Belghasem, Jean M. Francis, Naomi M. Hamburg, Sean Richards, Marc A Napoleon, Nader Rahimi
Publikováno v:
The Journal of Clinical Investigation
Chronic kidney disease (CKD) imposes a strong and independent risk for peripheral artery disease (PAD). While solutes retained in CKD patients (uremic solutes) inflict vascular damage, their role in PAD remains elusive. Here, we show that the dietary
Autor:
Lian Wu, Jiahai Zhou, Xuefeng Jiang, Youhua Yong, Jiahui Xue, Xin-Hao Li, Juan Lopez, Zixin Deng, Nathchar Naowarojna, Pinghua Liu, Rui Lai, Weiyao Hu, Stephen A. Whelan, Chao Peng, Norman Lee, Qiang Cui, Mark W. Grinstaff, Changming Zhao, Ronghai Cheng, Jie-Sheng Chen
Publikováno v:
ACS Catal
Ergothioneine, a natural longevity vitamin and antioxidant, is a thiol-histidine derivative. Recently, two types of biosynthetic pathways were reported. In the aerobic ergothioneine biosynthesis, a non-heme iron enzyme incorporates a sulfoxide to an
Autor:
Stephen A. Whelan, Jiangyun Wang, Zhihong Li, Lu Qiao, Juan Lopez, Pinghua Liu, Christina Wong, Qiang Cui, Rui Lai, Nathchar Naowarojna, Chao Peng, Mark W. Grinstaff, Kelin Li, Ronghai Cheng, Norman Lee
Publikováno v:
ACS Catal
In the anaerobic ergothioneine biosynthetic pathway, a rhodanese domain containing enzyme (EanB) activates tne hercynine’s sp(2) ε-C-H Dona ana replaces it with a C-S bond to produce ergothioneine. The key intermediate for this trans-sulfuration r
Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD
Autor:
Stephen A. Whelan, Sung Bok Yoo, Nkiruka Arinze, Joshua Walker, Saran Lotfollahzadeh, Teresa L Russell, Sean Richards, Laura M. Dember, Katya Ravid, Mostafa Belghasem, Norman Lee, Vipul C. Chitalia, Marc A Napoleon
Publikováno v:
J Am Soc Nephrol
BACKGROUND: CKD, characterized by retained uremic solutes, is a strong and independent risk factor for thrombosis after vascular procedures . Urem ic solutes such as indoxyl sulfate (IS) and kynurenine (Kyn) mediate prothrombotic effect through tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c7a1e4a4bb01e8e9ec4d2ed56388a3
https://europepmc.org/articles/PMC8806102/
https://europepmc.org/articles/PMC8806102/