Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Stephen A. Shinsky"'
Autor:
Haibing He, Guangkai Bian, Corey J. Herbst-Gervasoni, Takahiro Mori, Stephen A. Shinsky, Anwei Hou, Xin Mu, Minjian Huang, Shu Cheng, Zixin Deng, David W. Christianson, Ikuro Abe, Tiangang Liu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Terpene cyclases catalyze the formation of diverse hydrocarbon scaffolds found in terpenoids. Here, the authors report the cryptic function of class I terpene cyclases as aromatic prenyltransferases and the universality of this cryptic feature is con
Externí odkaz:
https://doaj.org/article/c70d380b1bf6424697e7827e67324201
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Polyamines bind to nucleic acids and their function is regulated by reversible acetylation. Here, the authors show that histone deacetylase 10 is a polyamine deacetylase and present its crystal structure with a bound polyamine transition state analog
Externí odkaz:
https://doaj.org/article/a275abbed63b43529d75e158a00c61cf
Autor:
Daniel Herp, Johannes Ridinger, Dina Robaa, Stephen A. Shinsky, Karin Schmidtkunz, Talha Z. Yesiloglu, Theresa Bayer, Raphael R. Steimbach, Corey J. Herbst‐Gervasoni, Annika Merz, Christophe Romier, Peter Sehr, Nikolas Gunkel, Aubry K. Miller, David W. Christianson, Ina Oehme, Wolfgang Sippl, Manfred Jung
Histone deacetylases (HDACs) are important epigenetic regulators involved in many diseases, especially cancer. Five HDAC inhibitors have been approved for anticancer therapy and many are in clinical trials. Among the 11 zinc-dependent HDACs, HDAC10 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12f6e164098dbd9c557478e7daf6594
Autor:
Tiangang Liu, Takahiro Mori, Stephen A. Shinsky, Haibing He, Xin Mu, Guangkai Bian, David W. Christianson, Zixin Deng, Ikuro Abe, Minjian Huang, Corey J Herbst-Gervasoni, Anwei Hou, Shu Cheng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Catalytic versatility is an inherent property of many enzymes. In nature, terpene cyclases comprise the foundation of molecular biodiversity as they generate diverse hydrocarbon scaffolds found in thousands of terpenoid natural products. Here, we rep
Publikováno v:
Biochemistry. 58:3755-3766
Polyamines are small organic cations that are essential for cellular function in all kingdoms of life. Polyamine metabolism is regulated by enzyme-catalyzed acetylation-deacetylation cycles in a fashion similar to the epigenetic regulation of histone
Autor:
Wolfgang Sippl, Peter Sehr, Talha Zahid Yesiloglu, Ina Oehme, Stephen A. Shinsky, Johannes Ridinger, David W. Christianson, Nikolas Gunkel, Dina Robaa, Theresa Bayer, Karin Schmidtkunz, Aubry K. Miller, Manfred Jung, Daniel Herp
Histone deacetylases (HDACs) are important epigenetic regulators involved in many diseases, esp. cancer. First HDAC inhibitors have been approved for anticancer therapy and many are in clinical trials. Among the 11 zinc-dependent HDACs, HDAC10 has re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d730b4047b2056ef78f16ebefddf27c
https://doi.org/10.26434/chemrxiv.12440096
https://doi.org/10.26434/chemrxiv.12440096
Publikováno v:
ACS Chem Biol
The natural product sesquisabinene is a key component of the fragrant essential oil of the sandalwood tree, currently valued at $5,000/L. Sesquisabinene contains a highly strained [3.1.0] bicyclic ring system and is generated from farnesyl diphosphat
Autor:
Deepak Kumar Jha, Catherine C. Fahey, Andy H. Vo, Yun Chen J. Chiang, Julia V. DiFiore, Kathryn E. Hacker, Stephen A. Shinsky, Ian J. Davis, Brian D. Strahl, W. Kimryn Rathmell, Jordan A. Shavit
Publikováno v:
Journal of Biological Chemistry. 291:21283-21295
The yeast Set2 histone methyltransferase is a critical enzyme that plays a number of key roles in gene transcription and DNA repair. Recently, the human homologue, SETD2, was found to be recurrently mutated in a significant percentage of renal cell c
Publikováno v:
The Journal of Biological Chemistry
Background: The mixed lineage leukemia 3 (MLL3) core complex catalyzes monomethylation of histone H3 lysine 4 (H3K4). Results: The WDR5 subunit is not required for MLL3 core complex assembly and partially inhibits methyltransferase activity. Conclusi
Autor:
Ashby J. Morrison, Raghuvar Dronamraju, Stephen A. Shinsky, Graeme J. Gowans, Natarajan V. Bhanu, Nicolas E. Buchler, Joseph B. Bridgers, Aline Thiengmany, Anthony Burnetti, Devin A. King, Jibo Zhang, Brian D. Strahl, Benjamin A. Garcia
Publikováno v:
Mol Cell
Metabolic signaling to chromatin often underlies how adaptive transcriptional responses are controlled. While intermediary metabolites serve as co-factors for histone-modifying enzymes during metabolic flux, how these modifications contribute to tran