Zobrazeno 1 - 10 of 88 pro vyhledávání: '"Stephen A. Mizsak"'
1
Syntheses of benzoquinolizidine and benzoindolizidine derivatives as anti-amnesic agents
Autor: Christopher L. Bacon, Andrew G. Foley, Michael J. Totleben, John M. Kelly, Stephen A. Mizsak, Shikai Zhao, Jacob Szmuszkovicz, Gerard B. Fox, U. Farrell, Ciaran M. Regan, Jeremiah P. Freeman, Esther O’Driscoll
Publikováno v: Bioorganic & Medicinal Chemistry. 7:1637-1646
Tacrine, one of the drugs available for Alzheimer's disease based on the cholinergic approach, suffers from considerable toxicity. Many analogues of tacrine have been prepared which retain the pharmacologically rich aminopyridine or aminoquinoline mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c625cf87a2e16c1a20846328ed3be1
https://doi.org/10.1016/s0968-0896(99)00078-4
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2
Biosynthesis of the Pipecolate Moiety of Marcfortine A
Autor: J. I. Cialdella, Stephen A. Mizsak, M. S. Kuo, D. A. Yurek, V. P. Marshall, L. Baczynskyj
Publikováno v: Journal of the American Chemical Society. 121:1763-1767
In this paper, we demonstrate that the marcfortine A (MA) producing Penicillium strain incorporates l-lysine, which is metabolized to the pipecolate moiety by losing the α-amino group and not the e...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8daa1cf013b8731276c74295dab146bc
https://doi.org/10.1021/ja983128d
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3
Cyclopentene Synthesis from 1,3-Dienes via Base-Induced Ring Contraction of 3,6-Dihydro-2H-thiopyrans: Studies on Diastereoselection and Mechanism
Autor: Brian E. Libby, Scott D. Larsen, Peter V. Fisher, Warren R. Ronk, W. Watt, Scott T. Hill, Stephen A. Mizsak, Randy M. Jensen
Publikováno v: The Journal of Organic Chemistry. 61:4725-4738
An investigation of the scope and mechanism of a new synthesis of cyclopentenes from 3,6-dihydro-2H-thiopyrans is described. Alkyl halides substituted with an electron-withdrawing group in the alpha-position were reacted with sodium thiosulfate, yiel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc936dd93d6330325ae5e5f683ea60c3
https://doi.org/10.1021/jo960537o
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4
Synthesis of an Azasteroid Using an Acyl Iminium Ion-Initiated Tandem Cyclization
Autor: Stephen A. Mizsak, Arthur Glenn Romero, Jeffrey A. Leiby
Publikováno v: The Journal of Organic Chemistry. 61:6974-6979
An acyl iminium ion-initiated tandem cyclization gave an unexpected dienone product, a seco-azasteroid (2). The factors governing the formation of 2 were investigated in an attempt to optimize its formation. The reaction was applied to a more elabora
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a715bf5988f3ed05b1d0858f564a8d
https://doi.org/10.1021/jo960673t
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6
A novel asymmetric synthesis of atropisomeric 6-aryl pyrazinones via an unusual chirality transfer process. New chiral ligands for the GABAA/Chloride ionophore complex
Autor: William Watt, Ronald B. Gammill, Stephen A. Mizsak, Lester A. Dolak, Thomas M. Judge, John Tulinsky
Publikováno v: Tetrahedron Letters. 36:2017-2020
Cyclization of ( S , S )- α -[(1-phenylethyl)amino]- α -(2-iodophenyl)acetonitrile 3a with (COCl) 2 in toluene or chlorobenzene afforeded the atropisomeric pyrazinone ( aS , S ) 6-(2-α-iodophenyl)-3,5-dichloro-1-(1-phenylethyl)-2(1H)-pyrazinone 7a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eff2345756001ff6a17273d17d49da76
https://doi.org/10.1016/0040-4039(95)00216-y
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7
Acis-1,2-DIAMINE FROM THE STEREOSELECTIVE REDUCTION OF AN α-AMINO ENAMINE
Autor: Shikai Zhao, Stephen A. Mizsak, Stan V. D'Andrea, Jacob Szmuszkovicz, Jeremiah P. Freeman
Publikováno v: Organic Preparations and Procedures International. 26:114-118
(1994). A cis-1,2-DIAMINE FROM THE STEREOSELECTIVE REDUCTION OF AN α-AMINO ENAMINE. Organic Preparations and Procedures International: Vol. 26, No. 1, pp. 114-118.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f114cbee0becd92645f484a985565c6d
https://doi.org/10.1080/00304949409458018
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8
Regioselective and stereoselective syntheses of 1,2,3-triaminocyclohexane derivatives
Autor: Stephen A. Mizsak, Jeremiah P. Freeman, Jacob Szmuszkovicz, Constance G. Chidester, Philip F. VonVoigtlander, Shikai Zhao
Publikováno v: The Journal of Organic Chemistry. 58:4043-4048
The reactions of trans- and cis-3-bromo-1,2-epoxycyclohexanes with pyrrolidine are described. While in the case of the trans-epoxide 2 the diamino alcohol 3 was obtained in benzene, the cis-epoxide 5 unexpectedly led to bromo amino alcohol 7 in benze
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a00cdcef064a26d1bae2c360cb93481a
https://doi.org/10.1021/jo00067a042
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9
Synthesis and biological activity of spirocyclic benzopyran imidazolone potassium channel openers
Autor: Bharat V. Kamdar, William Watt, Mark L. Wolfe, Vincent E. Groppi, Loretta A. Cipkus Dubray, Michael P. Smith, Robert C. Gadwood, Stephen A. Mizsak
Publikováno v: Journal of Medicinal Chemistry. 36:1480-1487
A series of novel spirocyclic benzopyran imidazolones were synthesized as rigid analogues of cromakalim. These compounds cause a dose-dependent membrane hyperpolarization of A10 rat aorta cells. This hyperpolarization was blocked by pretreatment with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57f66c957fa23d8308e33d322ac38c8
https://doi.org/10.1021/jm00062a022
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