Zobrazeno 1 - 10
of 555
pro vyhledávání: '"Stephen A. McMahon"'
Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
Autor:
Stephen A. McMahon, Wenlong Zhu, Shirley Graham, Robert Rambo, Malcolm F. White, Tracey M. Gloster
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Antiviral defence type III CRISPR systems produce cyclic oligoadenylates (cOA) as second messengers that activate downstream effectors. Here the authors present the crystal structure of the type III CRISPR defence DNA nuclease Can1 in complex with cy
Externí odkaz:
https://doaj.org/article/8e15c55ed2f04a3986e306637192568c
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Cyclic peptide macrocycles are promising anti-cancer and antimicrobial molecules. Here, the authors characterize the structure and catalytic mechanism of the prolyl oligopeptidase B from Basidiomycete fungi, showing that its dual macrocyclase-peptida
Externí odkaz:
https://doaj.org/article/6dc005fce7cd4bbe952d36cff3418252
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract There is agreement that high-LET radiation has a high Relative Biological Effectiveness (RBE) when delivered as a single treatment, but how it interacts with radiations of different qualities, such as X-rays, is less clear. We sought to clar
Externí odkaz:
https://doaj.org/article/a890c2850e504ea6a271d71550f9f850
Autor:
Samuel P. Ingram, John-William Warmenhoven, Nicholas T. Henthorn, Amy L. Chadiwck, Elham E. Santina, Stephen J. McMahon, Jan Schuemann, Norman F. Kirkby, Ranald I. Mackay, Karen J. Kirkby, Michael J. Merchant
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
PyFoci is a tool that simulates distributions of fluorescently labeled DNA double-strand break marker protein foci and allows the estimation of miscounting under different radiation types, doses and microscopy settings.
Externí odkaz:
https://doaj.org/article/12f2d24396fc42b6b08bfd133060527c
Autor:
Pankaj Chaudhary, Deborah C. Gwynne, Boris Odlozilik, Aaron McMurray, Giuliana Milluzzo, Carla Maiorino, Domenico Doria, Hamad Ahmed, Lorenzo Romagnani, Aaron Alejo, Hersimerjit Padda, James Green, David Carroll, Nicola Booth, Paul McKenna, Satyabrata Kar, Giada Petringa, Roberto Catalano, Francesco P. Cammarata, Giuseppe A. P. Cirrone, Stephen J. McMahon, Kevin M. Prise, Marco Borghesi
Publikováno v:
Radiation Oncology, Vol 17, Iss 1, Pp 1-14 (2022)
Abstract Background There is currently significant interest in assessing the role of oxygen in the radiobiological effects at ultra-high dose rates. Oxygen modulation is postulated to play a role in the enhanced sparing effect observed in FLASH radio
Externí odkaz:
https://doaj.org/article/c922634e63314088a19183d22aca3a4f
Autor:
Emily Russell, Victoria Dunne, Ben Russell, Hibaaq Mohamud, Mihaela Ghita, Stephen J. McMahon, Karl T. Butterworth, Giuseppe Schettino, Conor K. McGarry, Kevin M. Prise
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-16 (2021)
Abstract Purpose The recent implementation of MR-Linacs has highlighted theranostic opportunities of contrast agents in both imaging and radiotherapy. There is a lack of data exploring the potential of superparamagnetic iron oxide nanoparticles (SPIO
Externí odkaz:
https://doaj.org/article/395ba23d1e574bf1bc3495e2cccd624d
Autor:
Francisco D. C. Guerra Liberal, Hugo Moreira, Kelly M. Redmond, Joe M. O’Sullivan, Ali H. D. Alshehri, Timothy C. Wright, Victoria L. Dunne, Caoimhghin Campfield, Sandra Biggart, Stephen J. McMahon, Kevin M. Prise
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionRadium-223 (223Ra) has been shown to have an overall survival benefit in metastatic castration-resistant prostate cancer (mCRPC) involving bone. Despite its increased clinical usage, relatively little is known regarding the mechanism of a
Externí odkaz:
https://doaj.org/article/c036d2a956814f3e95393de65eb7ca6f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7861 (2023)
Intrinsic radiosensitivity is a major determinant of radiation response. Despite the extensive amount of radiobiological data available, variability among different studies makes it very difficult to produce high-quality radiosensitivity biomarkers o
Externí odkaz:
https://doaj.org/article/eb3c494789634deca1f46a4a2fc322f9
Autor:
Beatrice Oehler, Cindy Périer, Vincent Martin, Amy Fisher, Stéphane Lezmi, Mikhail Kalinichev, Stephen B. McMahon
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Well-established efficacy of botulinum neurotoxin type A (BoNT/A) in aesthetic dermatology and neuromuscular hyperactivity disorders relies on canonical interruption of acetylcholine neurotransmission at the neuromuscular junction at the site of the
Externí odkaz:
https://doaj.org/article/f1a3a232eb484ea6a8f97ed2adf83874
Autor:
Gabriel Adrian, Elise Konradsson, Sarah Beyer, Anders Wittrup, Karl T. Butterworth, Stephen J. McMahon, Mihaela Ghita, Kristoffer Petersson, Crister Ceberg
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundIrradiation with ultra-high dose rate (FLASH) has been shown to spare normal tissue without hampering tumor control in several in vivo studies. Few cell lines have been investigated in vitro, and previous results are inconsistent. Assuming
Externí odkaz:
https://doaj.org/article/469e2113cafa4b189229e664a90ccba4