Cytokine profiling in active and quiescent SLE reveals distinct patient subpopulations

Autor: John A. Reynolds, Eoghan M. McCarthy, Sahena Haque, Pintip Ngamjanyaporn, Jamie C. Sergeant, Elaine Lee, Eileen Lee, Stephen A. Kilfeather, Ben Parker, Ian N. Bruce

Publikováno v: Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018)

Abstract Background Patients with SLE display marked clinical and immunlogical heterogeneity. The purpose of the study was to investigate patterns of serum cytokines in patients with active and stable systemic lupus erythematosus (SLE) and to determi

Externí odkaz: https://doaj.org/article/2eb7a40d8551442da945519e96e73c23

Cytokine profiling in active and quiescent SLE reveals distinct patient subpopulations

Autor: Eoghan M. McCarthy, John A. Reynolds, Jamie C. Sergeant, Pintip Ngamjanyaporn, Ben Parker, Sahena Haque, Ian N. Bruce, Elaine Lee, Eileen Lee, Stephen A. Kilfeather

Publikováno v: Arthritis Research & Therapy
Reynolds, J, Mccarthy, E, Haque, S, Ngamjanyaporn, P, Sergeant, J, Lee, E, Lee, E, Kilfeather, S A, Parker, B & Bruce, I 2018, ' Cytokine profiling in active and quiescent SLE reveals distinct patient subpopulations ', Arthritis Research and Therapy, vol. 20, no. 173, 173 . https://doi.org/10.1186/s13075-018-1666-0
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018)

Background Patients with SLE display marked clinical and immunlogical heterogeneity. The purpose of the study was to investigate patterns of serum cytokines in patients with active and stable systemic lupus erythematosus (SLE) and to determine how th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf97db58bfd09800f5e0b3c24e9fb79
https://pubmed.ncbi.nlm.nih.gov/30092845

The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects

Autor: D MacLeod, Paul Sullivan, P Heath, Stephen A. Kilfeather, P L Harbinson, S O'Toole, Clive P. Page, J F Costello, S. T. Holgate, Richard J. Hawksworth, Tak H. Lee

Publikováno v: European Respiratory Journal. 10:1008-1014

Recent studies have suggested that theophylline, a nonspecific phospho-diesterase inhibitor, has useful anti-inflammatory actions in asthma. Phosphodiesterase 4 (PDE4) represents the predominant PDE isoenzyme present in inflammatory cells. PDE4 inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0ac3e65e5f0db6f291902f905cbaa2
https://doi.org/10.1183/09031936.97.10051008

Effects of tetrandrine on growth factor-induced DNA synthesis and proliferative response of rat pulmonary artery smooth muscle cells

Autor: Stephen A. Kilfeather, G R Martin, Clive P. Page, Huai-Liang Wang

Publikováno v: Pulmonary pharmacologytherapeutics. 13(2)

The objective of the present study was to investigate the effect of tetrandrine (a plant alkaloid isolated from Stephenia tetrandra) on growth factor-induced DNA synthesis and proliferative responses of rat pulmonary artery smooth muscle cells. Male

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bebdbfa7910ec64981acd1ee61e28ab
https://pubmed.ncbi.nlm.nih.gov/10799282

Effect of chronic theophylline treatment on the methacholine dose-response curve in allergic asthmatic subjects

Autor: J F Costello, T Cotter, Stephen A. Kilfeather, Clive P. Page, Domenico Spina, Paul Sullivan

Publikováno v: The European respiratory journal. 12(1)

Theophylline is a bronchodilator and immunomodulator drug which has recently been demonstrated to attenuate the recruitment and activation of inflammatory cells into lungs of asthmatics. This study investigated the effect of chronic treatment with th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d0256a9601f1bcd7404adcb41f1dcc
https://pubmed.ncbi.nlm.nih.gov/9701409