Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Stephen A. Kempson"'
Publikováno v:
Cellular Physiology and Biochemistry, Vol 32, Iss 1, Pp 32-40 (2013)
Betaine, also known as trimethylglycine, is an important human nutrient obtained from a variety of foods and also can be synthesized from choline. Betaine is much more abundant in kidney and liver compared to other mammalian organs. The principal rol
Externí odkaz:
https://doaj.org/article/fafeda4d83eb4caf8b012acfaa9a38e8
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
The physiological roles of the betaine/GABA transporter (BGT1; slc6a12) are still being debated. BGT1 is a member of the solute carrier family 6 (the neurotransmitter, sodium symporter transporter family) and mediates cellular uptake of betaine and G
Externí odkaz:
https://doaj.org/article/5f0adad4f1d8417a8e99bd1f2ee36f35
Autor:
Stephen A. Kempson, Christopher R. Day
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:1098-1106
Background Betaine is the trimethyl derivative of glycine and is normally present in human plasma due to dietary intake and endogenous synthesis in liver and kidney. Betaine is utilized in the kidney primarily as an osmoprotectant, whereas in the liv
Autor:
Christine Ziegler, Stephen A. Kempson, Friedericke Joos, Birgitta C. Burckhardt, Eva S. Schweikhard, Cristina Fenollar-Ferrer, Lucy R. Forrest
Publikováno v:
Biochemical Journal. 470:169-179
The osmolyte and folding chaperone betaine is transported by the renal Na + -coupled GABA (γ-aminobutyric acid) symporter BGT-1 (betaine/GABA transporter 1), a member of the SLC6 (solute carrier 6) family. Under hypertonic conditions, the transcript
Publikováno v:
American Journal of Physiology-Renal Physiology. 307:F107-F115
Betaine is an important osmolyte and is, compared with other organs, much more abundant in the kidneys, where it enters cells in the medulla by betaine-GABA transporter 1 (BGT1) to balance osmoregulation in the countercurrent system. In wild-type (wt
Publikováno v:
Physiology Journal. 2013:1-9
One response to hypertonic stress in the renal medulla and MDCK cells is the upregulation of betaine transporter (BGT1) synthesis, followed by trafficking to the plasma membrane (PM) and an increase in betaine transport. Upregulation of BGT1 was enha
Publikováno v:
Cellular Physiology and Biochemistry, Vol 32, Iss 1, Pp 32-40 (2013)
Betaine, also known as trimethylglycine, is an important human nutrient obtained from a variety of foods and also can be synthesized from choline. Betaine is much more abundant in kidney and liver compared to other mammalian organs. The principal rol
Autor:
Anna Maria Olofsson, Silvia Holmseth, Rui Hua, Yun Zhou, Niels C. Danbolt, Irais Poblete-Naredo, Anne-Catherine Lehre, Stephen A. Kempson
Publikováno v:
American Journal of Physiology-Renal Physiology. 302:F316-F328
The Na+- and Cl−-dependent GABA-betaine transporter (BGT1) has received attention mostly as a protector against osmolarity changes in the kidney and as a potential controller of the neurotransmitter GABA in the brain. Nevertheless, the cellular dis
Publikováno v:
The Open Urology & Nephrology Journal. 2:6-10
Non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most common classes of medications used worldwide for treatment of pain and inflammation, and their nephrotoxic effects have been well documented. This study is focused on aspirin ac
Publikováno v:
Nitric Oxide. 17:33-43
Renal tubules process large amounts of NaCl that other investigators indicate increases tubular generation of nitric oxide. We questioned whether medullary or superficial cortical tubules would have the greater increase in nitric oxide concentration,