Zobrazeno 1 - 10
of 650
pro vyhledávání: '"Stephen A. Hill"'
Autor:
Sean A. Cullum, Simon Platt, Natasha Dale, Oliver C. Isaac, Edward S. Wragg, Mark Soave, Dmitry B. Veprintsev, Jeanette Woolard, Laura E. Kilpatrick, Stephen J. Hill
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The concept of agonist-independent signalling that can be attenuated by inverse agonists is a fundamental element of the cubic ternary complex model of G protein-coupled receptor (GPCR) activation. This model shows how a GPCR can exist in tw
Externí odkaz:
https://doaj.org/article/1c67926d1da64115a6683f7383bac865
Autor:
Foteini Patera, Sarah J. Mistry, Nicholas D. Kindon, Eleonora Comeo, Joelle Goulding, Barrie Kellam, Laura E. Kilpatrick, Hester Franks, Stephen J. Hill
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract Fluorescent ligands have proved to be powerful tools in the study of G protein‐coupled receptors in living cells. Here we have characterized a new fluorescent ligand PSB603‐BY630 that has high selectivity for the human adenosine A2B rece
Externí odkaz:
https://doaj.org/article/a1c24b9076b34d2fa29863a2ebd18f8f
Autor:
Matt N. Williams, Mathew Ling, John R. Kerr, Stephen R. Hill, Mathew D. Marques, Hollie Mawson, Edward J. R. Clarke
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Recent research has produced a significant body of knowledge about the antecedents and consequences of individual differences in belief in conspiracy theories. What is less clear, however, is the extent to which individuals’ beliefs in con
Externí odkaz:
https://doaj.org/article/a2fdc925fe4f4646b00c804d73b76db5
Autor:
Emma E. H. Doyle, Jessica Thompson, Stephen R. Hill, Matt Williams, Douglas Paton, Sara E. Harrison, Ann Bostrom, Julia S. Becker
Publikováno v:
Frontiers in Communication, Vol 9 (2024)
IntroductionWe conducted mental model interviews in Aotearoa NZ to understand perspectives of uncertainty associated with natural hazards science. Such science contains many layers of interacting uncertainties, and varied understandings about what th
Externí odkaz:
https://doaj.org/article/080c9f464b9c4e3580e703b59d5f11a1
Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Association of single nucleotide polymorphisms in the IL-23 receptor with several auto-inflammatory diseases, led to the heterodimeric receptor and its cytokine-ligand IL-23, becoming important drug targets. Successful antibody-based therapi
Externí odkaz:
https://doaj.org/article/86032f589b894097a542dab777945e85
Publikováno v:
Open Journal of Occupational Therapy, Vol 10, Iss 4, Pp 1-14 (2022)
Background: Three-dimensional (3D) human motion analysis provides objective, quantitative, and reliable kinematic data that are valuable in rehabilitation. Clinicians, including occupational therapists and other specialists, can apply this technology
Externí odkaz:
https://doaj.org/article/672465c0daa4439d90b9c3dce41a022d
Autor:
Lydia Ogrodzinski, Simon Platt, Joelle Goulding, Cameron Alexander, Tracy D. Farr, Jeanette Woolard, Stephen J. Hill, Laura E. Kilpatrick
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107232- (2023)
Summary: E-selectin is expressed on endothelial cells in response to inflammatory cytokines and mediates leukocyte rolling and extravasation. However, studies have been hampered by lack of experimental approaches to monitor expression in real time in
Externí odkaz:
https://doaj.org/article/d9a9d8a2d0b142e5910a28b5858b94d3
Autor:
Stephen l Hill
Publikováno v:
SAGE Open Medicine, Vol 11 (2023)
Objectives: The surgery for dialysis access has changed over the past 38 years. In the 1980s and 1990s, prosthetic grafts were the most common form of access. Then, autogenous fistulae had a rebirth due to their durability and decreased complications
Externí odkaz:
https://doaj.org/article/828803d9b69742e79a60c9565aa5ba39
Autor:
Dehan Comez, Jacqueline Glenn, Stephanie M. Anbuhl, Raimond Heukers, Martine J. Smit, Stephen J. Hill, Laura E. Kilpatrick
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionThe Epidermal Growth Factor Receptor is a member of the Erb receptor tyrosine kinase family. It binds several ligands including EGF, betacellulin (BTC) and TGF-α, controls cellular proliferation and invasion and is overexpressed in vario
Externí odkaz:
https://doaj.org/article/05d30db7c8be4764811481e7f4448f13
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 3, Pp n/a-n/a (2022)
Abstract A2A and A2B adenosine receptors produce regionally selective regulation of vascular tone and elicit differing effects on mean arterial pressure (MAP), whilst inducing tachycardia. The tachycardia induced by the stimulation of A2A or A2B rece
Externí odkaz:
https://doaj.org/article/0f022b6b00b24ed4aabe4c0461bf80ac