Zobrazeno 1 - 10
of 412
pro vyhledávání: '"Stephen A. Duncan"'
Autor:
Jui-Tung Liu, Caren Doueiry, Yu-lin Jiang, Josef Blaszkiewicz, Mary Paige Lamprecht, James A. Heslop, Yuri K. Peterson, Juliana Debrito Carten, Paula Traktman, Yang Yuan, Salman R. Khetani, Waleed O. Twal, Stephen A. Duncan
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Familial hypercholesterolemia (FH) patients suffer from excessively high levels of Low Density Lipoprotein Cholesterol (LDL-C), which can cause severe cardiovascular disease. Statins, bile acid sequestrants, PCSK9 inhibitors, and cholesterol
Externí odkaz:
https://doaj.org/article/fe36e9c4a8724c3384dc661b32a9f5f8
Autor:
Shasha Yin, Liu Liu, Lauren E. Ball, Yalong Wang, Mark T. Bedford, Stephen A. Duncan, Haizhen Wang, Wenjian Gan
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112316- (2023)
Summary: The mammalian target of rapamycin complex1 (mTORC1) is a central regulator of metabolism and cell growth by sensing diverse environmental signals, including amino acids. The GATOR2 complex is a key component linking amino acid signals to mTO
Externí odkaz:
https://doaj.org/article/eabff953454641b384853ab480a49a89
Autor:
Kareem A. Heslop, Pieter Burger, Christiana Kappler, Ashish K. Solanki, Monika Gooz, Yuri K. Peterson, Catherine Mills, Thomas Benton, Stephen A. Duncan, Patrick M. Woster, Eduardo N. Maldonado
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 150, Iss , Pp 112928- (2022)
Voltage dependent anion channels (VDAC) control the flux of most anionic respiratory substrates, ATP, ADP, and small cations, crossing the outer mitochondrial membrane. VDAC closure contributes to the partial suppression of mitochondrial metabolism t
Externí odkaz:
https://doaj.org/article/b7edd7c2a82c4166a08fa15b6e90f3ee
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104300- (2022)
Summary: In addition to cooperatively driving transcriptional programs, emerging evidence supports transcription factors interacting with one another to modulate the outcome of binding events. As such, transcription factor interactions fine-tune the
Externí odkaz:
https://doaj.org/article/b8324477e2954838a5aad424be824cd7
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109145- (2021)
Summary: In addition to driving specific gene expression profiles, transcriptional regulators are becoming increasingly recognized for their capacity to modulate chromatin structure. GATA6 is essential for the formation of definitive endoderm; howeve
Externí odkaz:
https://doaj.org/article/a536369f410c44e982ef50dbf4afcd0f
Autor:
Behshad Pournasr, Stephen A. Duncan
Publikováno v:
Stem Cell Research, Vol 48, Iss , Pp 101953- (2020)
Propionic acidemia (PA) is an autosomal recessive metabolic liver disease caused by defects in propionyl CoA carboxylase. Propionyl CoA carboxylase is a dodecameric enzyme consisting of multiple copies of alpha and beta subunits encoded by the PCCA a
Externí odkaz:
https://doaj.org/article/0bc9005894eb42508f96050979d107b0
Publikováno v:
PeerJ, Vol 8, p e9060 (2020)
Genome editing in human induced pluripotent stem cells (iPSCs) provides the potential for disease modeling and cell therapy. By generating iPSCs with specific mutations, researchers can differentiate the modified cells to their lineage of interest fo
Externí odkaz:
https://doaj.org/article/dbfa97270f1f4b96b46af3a45b811550
Autor:
Gray Evans, Christiana S. Kappler, Ray Liu, Juliana D. Carten, Cody M. Orr, Sarah Stephenson, Paula Traktman, Stephen A. Duncan, Eric G. Meissner
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 14-15 (2021)
ABSTRACT IMPACT: We hope to provide a more nuanced understanding of the type-III IFN system, thereby exploring its therapeutic potential in the realm of infectious diseases. OBJECTIVES/GOALS: The role of IFNLR1 receptor dynamics and plasticity in reg
Externí odkaz:
https://doaj.org/article/4493cce05d4548e0a02e98cefe3f83d4
Autor:
Ying Liu, Donna M. Conlon, Xin Bi, Katherine J. Slovik, Jianting Shi, Hailey I. Edelstein, John S. Millar, Ali Javaheri, Marina Cuchel, Evanthia E. Pashos, Jahangir Iqbal, M. Mahmood Hussain, Robert A. Hegele, Wenli Yang, Stephen A. Duncan, Daniel J. Rader, Edward E. Morrisey
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1456-1466 (2017)
Abetalipoproteinemia (ABL) is an inherited disorder of lipoprotein metabolism resulting from mutations in microsomal triglyceride transfer protein (MTTP). In addition to expression in the liver and intestine, MTTP is expressed in cardiomyocytes, and
Externí odkaz:
https://doaj.org/article/d7125650f9fd4644a056f52767d91fcf
Autor:
Xin Bi, Evanthia E. Pashos, Marina Cuchel, Nicholas N. Lyssenko, Mayda Hernandez, Antonino Picataggi, James McParland, Wenli Yang, Ying Liu, Ruilan Yan, Christopher Yu, Stephanie L. DerOhannessian, Michael C. Phillips, Edward E. Morrisey, Stephen A. Duncan, Daniel J. Rader
Publikováno v:
EBioMedicine, Vol 18, Iss C, Pp 139-145 (2017)
Despite the recognized role of the ATP-binding Cassette Transporter A1 (ABCA1) in high-density lipoprotein (HDL) metabolism, our understanding of ABCA1 deficiency in human hepatocytes is limited. To define the functional effects of human hepatocyte A
Externí odkaz:
https://doaj.org/article/946ab8b7ea644fcfaed179b2dcca84c0