Optimizations of lipid II synthesis: an essential glycolipid precursor in bacterial cell wall synthesis and a validated antibiotic target

Autor: Milandip Karak, Cian R. Cloonan, Brad R. Baker, Rachel V. K. Cochrane, Stephen A. Cochrane

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 220-227 (2024)

Lipid II is an essential glycolipid found in bacteria. Accessing this valuable cell wall precursor is important both for studying cell wall synthesis and for studying/identifying novel antimicrobial compounds. Herein, we describe optimizations to the

Externí odkaz: https://doaj.org/article/c1986121f19943f99d556cd95b504c5f

Linearization of the brevicidine and laterocidine lipopeptides yields analogues that retain full antibacterial activity

Autor: Ross D. Ballantine, Karol Al Ayed, Samantha J. Bann, Michael Hoekstra, Nathaniel I. Martin, Stephen A. Cochrane

Publikováno v: Ballantine, R D, Al Ayed, K, Bann, S J, Hoekstra, M, Martin, N I & Cochrane, S A 2023, ' Linearization of the brevicidine and laterocidine lipopeptides yields analogues that retain full antibacterial activity ', Journal of Medicinal Chemistry, vol. 66, no. 8, pp. 6002–6009 . https://doi.org/10.1021/acs.jmedchem.3c00308

Brevicidine and laterocidine are macrocyclic lipodepsipeptides with selective activity against Gram-negative bacteria, including colistin-resistant strains. Previously, the macrocyclic core of these peptides was thought essential for antibacterial ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09c03c0cc76ae7e5befbc94a8558900
https://pure.qub.ac.uk/en/publications/b4f5f24c-7d26-4f15-abf5-6953f2f2c8b3

Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine

Autor: Ross D. Ballantine, Karol Al Ayed, Samantha J. Bann, Michael Hoekstra, Nathaniel I. Martin, Stephen A. Cochrane

Publikováno v: Ballantine, R D, Al Ayed, K, Bann, S J, Hoekstra, M, Martin, N I & Cochrane, S A 2022, ' Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine ', RSC Medicinal Chemistry, vol. 13, no. 12, pp. 1640-1643 . https://doi.org/10.1039/D2MD00281G
RSC Medicinal Chemistry, 13, 1640-1643. Royal Society of Chemistry (RSC)

The brevicidine and laterocidine family of lipopeptide antibiotics exhibit strong activity against multidrug-resistant Gram-negative bacteria, while showing low propensity to induce resistance. Both peptides feature a branched lipid tail on the N-ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121dece8cf31225048d484c4d78ce224
https://pure.qub.ac.uk/en/publications/64b92b45-9d67-43eb-a9f8-6feea03fd68f

Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and

Autor: Karol, Al Ayed, Ross D, Ballantine, Michael, Hoekstra, Samantha J, Bann, Charlotte M J, Wesseling, Alexander T, Bakker, Zheng, Zhong, Yong-Xin, Li, Nora C, Brüchle, Mario, van der Stelt, Stephen A, Cochrane, Nathaniel I, Martin

Publikováno v: Chemical science. 13(12)

Brevicidine and laterocidine are two recently discovered lipopeptide antibiotics with promising antibacterial activity. Possessing a macrocyclic core, multiple positive charges, and a lipidated N-terminus, these lipopeptides exhibit potent and select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e304ff04a2c60c19c28036840a6d5528
https://pubmed.ncbi.nlm.nih.gov/35432860

Total Synthesis of the Brevicidine and Laterocidine Family of Lipopeptide Antibiotics

Autor: Nathaniel I. Martin, Li Y, Stephen A. Cochrane, Al-Ayed K, Ballantine Rd, Zhong Z

Brevicidine and laterocidine are two recently discovered lipopeptide antibiotics with promising antibacterial activity. Possessing a macrocyclic core, multiple positive charges, and a lipidated N-terminus, these lipopeptides exhibit potent and select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b76b7ae34cf983f9ffbc6b68018a5a3
https://doi.org/10.26434/chemrxiv.13660949.v1