Výsledky vyhledávání - "Stephen A. Ainger"

Data from Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo

Autor: Brian Gabrielli, Nikolas K. Haass, Richard A. Sturm, Stephen A. Ainger, Loredana Spoerri, Dubravka Škalamera, James Chen, Catherine Lanagan, Sebastian Walpole, Sheena M. Daignault, Martina Proctor, Alexander J. Stevenson, Zay Yar Oo

Purpose: Checkpoint kinase 1 inhibitors (CHEK1i) have single-agent activity in vitro and in vivo. Here, we have investigated the molecular basis of this activity.Experimental Design: We have assessed a panel of melanoma cell lines for their sensitivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2d500d668d42bc11bf309dc19b22bf
https://doi.org/10.1158/1078-0432.c.6525843

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Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo

Autor: Martina Proctor, Catherine Lanagan, Stephen A. Ainger, Sebastian Walpole, James Chen, Richard A. Sturm, Dubravka Skalamera, Alexander J. Stevenson, Brian Gabrielli, Loredana Spoerri, Nikolas K. Haass, Zay Yar Oo, S. M. Daignault

Publikováno v: Clinical Cancer Research. 24:2901-2912

Purpose: Checkpoint kinase 1 inhibitors (CHEK1i) have single-agent activity in vitro and in vivo. Here, we have investigated the molecular basis of this activity. Experimental Design: We have assessed a panel of melanoma cell lines for their sensitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd5bc21ec119d1e4c2ddf3ab214adf8
https://doi.org/10.1158/1078-0432.ccr-17-2701

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Testing of viable human skin cell dilution cultures as an approach to validating microsampling

Autor: Richard A. Sturm, H. Peter Soyer, X. L. Hilary Yong, Stephen A. Ainger

Publikováno v: Archives of Dermatological Research. 309:305-310

Skin biopsies are a valuable technique in the diagnosis of cutaneous inflammatory and neoplastic conditions. We were interested to test the minimal size or equivalent volume by dilution of proteolytically disassociated skin tissue required to allow t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096307aaaaeeecc5a59818d8a63e2a96
https://doi.org/10.1007/s00403-017-1726-3

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Melanoma mutations modify melanocyte dynamics in co-culture with keratinocytes or fibroblasts

Autor: Stephen A. Ainger, Anna Ehmann, Catherine Lanagan, Brian Gabrielli, Richard A. Sturm, Alexander J. Stevenson, Dubravka Skalamera

Publikováno v: Journal of cell science. 132(24)

Melanocytic cell interactions are integral to skin homeostasis, and affect the outcome of multiple diseases, including cutaneous pigmentation disorders and melanoma. By using automated-microscopy and machine-learning-assisted morphology analysis of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcd6edf1d3a318e27ef5b95ded65b15
https://pubmed.ncbi.nlm.nih.gov/31767623

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Skin Pigmentation Genetics for the Clinic

Autor: Katie J. Lee, Stephen A. Ainger, H. Peter Soyer, Richard A. Sturm, K. Jagirdar

Publikováno v: Dermatology. 233:1-15

Human pigmentation characteristics play an important role in the effects of sun exposure, skin cancer induction and disease outcomes. Several of the genes most important for this diversity are involved in the regulation and distribution of melanin pi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a38533691b0d806618d3428c57fbd29
https://doi.org/10.1159/000468538

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Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon-gamma response in melanocytic cells

Autor: Reuben S.Q. Kim, Stephen A. Ainger, Hilary X.L. Yong, Aaron G. Smith, Wen Lim, Melinda M. Ashcroft, Richard A. Sturm, Arish Soogrim, Dayana Nur Mahiuddin, Mitchell Fane, Graeme J. Walker, Scott A. Beatson, Darren J. Smit, Yash Chhabra, K. Jagirdar

Publikováno v: Pigment cellmelanoma research. 31(1)

A SNP within intron4 of the interferon regulatory factor4 (IRF4) gene, rs12203592*C/T, has been independently associated with pigmentation and age-specific effects on naevus count in European-derived populations. We have characterized the cis-regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9165186052e4c87b7739e478f9020803
https://pubmed.ncbi.nlm.nih.gov/28755520

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DCT protects human melanocytic cells from UVR and ROS damage and increases cell viability

Autor: J. Helen Leonard, Xuan L. Yong, Stephen A. Ainger, Dubravka Skalamera, Shu Shyan Wong, Brian Gabrielli, Richard A. Sturm

Publikováno v: Experimental Dermatology. 23:916-921

Dopachrome tautomerase (DCT) is involved in the formation of the photoprotective skin pigment eumelanin and has also been shown to have a role in response to apoptotic stimuli and oxidative stress. The effect of DCT on UVR DNA damage responses and su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea34f0837263e0c11ad69149f282c048
https://doi.org/10.1111/exd.12574

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MC1R Variant Allele Effects on UVR-Induced Phosphorylation of p38, p53, and DDB2 Repair Protein Responses in Melanocytic Cells in Culture

Autor: Shu Shyan Wong, Stephen A. Ainger, Richard A. Sturm, J. Helen Leonard

Publikováno v: Journal of Investigative Dermatology. 132:1452-1461

Variant alleles of the human melanocortin 1 receptor (MC1R) reduce the ability of melanocytes to produce the dark pigment eumelanin, with R alleles being most deficient. Cultured melanocytes of MC1R R/R variant genotype give reduced responses to [Nle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e2851192bcbea4352b9da274007bda
https://doi.org/10.1038/jid.2011.473

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Melanocortin MC1 receptor in human genetics and model systems

Autor: Glenn L. Millhauser, Kimberley A. Beaumont, Shu Shyan Wong, Mira Patel, Richard A. Sturm, Jennifer J. Smith, Yan Yan Liu, Paul F. Alewood, Stephen A. Ainger, J. Helen Leonard

Publikováno v: European Journal of Pharmacology. 660:103-110

The melanocortin MC(1) receptor is a G-protein coupled receptor expressed in the melanocytes of the skin and hair and is known for its key role in the regulation of human pigmentation. Melanocortin MC(1) receptor activation after ultraviolet radiatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b525de6d23f4f8308131a81a59588b73
https://doi.org/10.1016/j.ejphar.2010.11.040

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