Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Stephen A. Adam"'
Autor:
Suganya Sivagurunathan, Amir Vahabikashi, Haiqian Yang, Jun Zhang, Kelly Vazquez, Dhivyaa Rajasundaram, Yuliya Politanska, Hiam Abdala-Valencia, Jacob Notbohm, Ming Guo, Stephen A. Adam, Robert D. Goldman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Vimentin is a Type III intermediate filament (VIF) cytoskeletal protein that regulates the mechanical and migratory behavior of cells. Its expression is considered to be a marker for the epithelial to mesenchymal transition (EMT) that takes place in
Externí odkaz:
https://doaj.org/article/77d566af8a374e9e9a874adf3df64d39
Publikováno v:
APL Bioengineering, Vol 6, Iss 1, Pp 011503-011503-11 (2022)
Nuclear lamins are type V intermediate filament proteins that polymerize into complex filamentous meshworks at the nuclear periphery and in less structured forms throughout the nucleoplasm. Lamins interact with a wide range of nuclear proteins and ar
Externí odkaz:
https://doaj.org/article/11845f71dba34e3d8071d5a8b75a421e
Publikováno v:
Nucleic acids research. 50(20)
The chromatin associated with the nuclear lamina (NL) is referred to as lamina-associated domains (LADs). Here, we present an adaptation of the tyramide-signal amplification sequencing (TSA-seq) protocol, which we call chromatin pull down-based TSA-s
Publikováno v:
Cytoskeleton (Hoboken, N.J.). 79(6-8)
Stereocilia are actin-based projections of hair cells that are arranged in a step like array, in rows of increasing height, and that constitute the mechanosensory organelle used for the senses of hearing and balance. In order to function properly, st
Autor:
Amir Vahabikashi, Suganya Sivagurunathan, Fiona Ann Sadsad Nicdao, Yu Long Han, Chan Young Park, Mark Kittisopikul, Xianrong Wong, Joseph R. Tran, Gregg G. Gundersen, Karen L. Reddy, G. W. Gant Luxton, Ming Guo, Jeffrey J. Fredberg, Yixian Zheng, Stephen A. Adam, Robert D. Goldman
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell mechanics through poorly understood mechanisms. Here we cond
Autor:
Stephen A. Adam, Yinan Shen, David A. Weitz, Suganya Sivagurunathan, Huayin Wu, Jennifer Hyunjong Shin, Ohad Medalia, Jeffrey J. Fredberg, Robert D. Goldman, Miriam Weber
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(10)
The cytoskeleton of eukaryotic cells is primarily composed of networks of filamentous proteins, F-actin, microtubules, and intermediate filaments. Interactions among the cytoskeletal components are important in determining cell structure and in regul
Autor:
Yohei Kono, Stephen A. Adam, Karen L. Reddy, Yixian Zheng, Ohad Medalia, Robert D. Goldman, Hiroshi Kimura, Takeshi Shimi
In mammalian cell nuclei, the nuclear lamina (NL) underlies the nuclear envelope (NE) to maintain nuclear structure. The nuclear lamins, the major structural components of the NL, are involved in the protection against NE rupture induced by mechanica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510271aaa8cae0f7088a3f68c5e54aed
https://doi.org/10.1101/2022.01.05.475028
https://doi.org/10.1101/2022.01.05.475028
Autor:
Stephen A. Adam, Karen L. Reddy, Suganya Sivagurunathan, Chan Young Park, Robert D. Goldman, Yixian Zheng, Tran, Wong X, Jeffrey J. Fredberg, Gregg G. Gundersen, Amir Vahabikashi, Nicdao Fas, Ming Guo, Yu Long Han, Luxton Gg
The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell mechanics through poorly understood mechanisms. Here we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59d2872e5ecc95c3d1aa2059959c0ddd
https://doi.org/10.1101/2021.05.12.443683
https://doi.org/10.1101/2021.05.12.443683
Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation
Autor:
Stephen A. Adam, Robert D. Goldman, Luay M. Almassalha, Vadim Backman, Andrew D. Stephens, John F. Marko, Viswajit Kandula, Edward J. Banigan, Haimei Chen, Thomas V. O'Halloran, Cameron Herman, Patrick Z. Liu
Publikováno v:
Molecular Biology of the Cell
The nucleus houses, organizes, and protects chromatin to ensure genome integrity and proper gene expression, but how the nucleus adapts mechanically to changes in the extracellular environment is poorly understood. Recent studies have revealed that e
Autor:
Joseph J. Lee, Arthur Beyder, Robert D. Goldman, Ronen Sumagin, Veronika Butin-Israeli, Lorraine A. Mascarenhas, Lindsey C. Mehl, Lisa Wiesmüller, Triet M. Bui, Hannah L. Wiesolek, Stephen A. Adam, Stephen B. Hanauer, Kaitlyn R. Knutson
Publikováno v:
Journal of Clinical Investigation. 129:712-726
Neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark of tissue injury associated with inflammatory bowel diseases (IBDs). The pathological effects of PMNs are largely attributed to the release of soluble mediators and reactive oxygen