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pro vyhledávání: '"Stephen A. Glover"'
Autor:
Stephen A. Glover, Adam A. Rosser
Publikováno v:
Amide Bond Activation. :29-77
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9566149d58f0e3a8daf8b12176fa51f3
https://doi.org/10.1002/9783527830251.ch2
https://doi.org/10.1002/9783527830251.ch2
Heteroatom Substitution at Amide Nitrogen—Resonance Reduction and HERON Reactions of Anomeric Amides
Autor:
Stephen A. Glover, Adam A. Rosser
Publikováno v:
Molecules, Vol 23, Iss 11, p 2834 (2018)
This review describes how resonance in amides is greatly affected upon substitution at nitrogen by two electronegative atoms. Nitrogen becomes strongly pyramidal and resonance stabilisation, evaluated computationally, can be reduced to as little as 5
Externí odkaz:
https://doaj.org/article/47d07bb86c124e2897e19c48a1ef7684
Autor:
Stephen A. Glover
Publikováno v:
ARKIVOC, Vol 2001, Iss 12, Pp 143-160 (2002)
Externí odkaz:
https://doaj.org/article/555e31d64cec4189ae0c7a2d68aaf6bc
Autor:
Adam A. Rosser, Stephen A. Glover
Publikováno v:
Canadian Journal of Chemistry. 94:1169-1180
Anomeric amides, RCON(X)(Y), have two electronegative atoms at the amide nitrogen, a configuration that results in greatly reduced amide resonance and strongly pyramidal nitrogen atoms. This, combined with facilitation of anomeric interactions, can r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10a0e6c7f9574a4b8aa43dfd5a7ef5e7
https://doi.org/10.1139/cjc-2016-0300
https://doi.org/10.1139/cjc-2016-0300
Autor:
Stephen A. Glover
Publikováno v:
Physical chemistry chemical physics : PCCP. 21(32)
The nature of amide resonance in the β-lactam ring of β-propiolactams and penicillin type structures has been evaluated by the Mucsi hydrogenation method on the one hand, and isodesmic trans-amidation (TA) and the carbonyl substitution nitrogen ato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200fd3a1c49c8d079bd1e229d47ade58
https://pubmed.ncbi.nlm.nih.gov/23760063
https://pubmed.ncbi.nlm.nih.gov/23760063
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. :503299
N-Acyloxy-N-alkoxyamides are direct-acting mutagens in S. typhimurium TA100 and TA98. A reliable QSAR for their activity in TA100 has been developed, which indicates reversible intercalation into the DNA helix through naphthalene substituents. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97e3504d37183e9b526d10d366fd1a6
https://doi.org/10.1016/j.mrgentox.2020.503299
https://doi.org/10.1016/j.mrgentox.2020.503299
Publikováno v:
Organic & Biomolecular Chemistry. 14:3699-3714
N-Acyloxy-N-alkoxyamides are direct-acting mutagens in S. typhimurium TA100 with a linear dependence upon log P that maximises at log P0 = 6.4. Eight N-acyloxy-N-alkoxyamides (2–9) bearing a naphthalene group on any of the three side-chains and wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a3d142bafee23e74ed5834a0ff4377
https://doi.org/10.1039/c6ob00162a
https://doi.org/10.1039/c6ob00162a
Publikováno v:
Synlett. 26:111-115
Protected inosose 2- O -mesylates generate oxyallyl systems by elimination of the mesylate group after enolization. The reaction is promoted by weak bases such as triethylamine and azide, and the oxyallyl systems are then trapped by nucleophilic alco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beaa243c60f04a952fa8c497481997f0
https://doi.org/10.1055/s-0034-1379490
https://doi.org/10.1055/s-0034-1379490
Autor:
Stephen A. Glover, Adam A. Rosser
Publikováno v:
Journal of Physical Organic Chemistry. 28:215-222
Calculations show that anomeric amides, amides bearing two electronegative atoms at the amide nitrogen, are unusual in structure and reactivity. They have much reduced amide resonance and also undergo the HERON reaction where anomeric destabilisation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99c04f3659f4d9600cd3e09e772aeca7
https://doi.org/10.1002/poc.3322
https://doi.org/10.1002/poc.3322
Publikováno v:
Organicbiomolecular chemistry. 14(28)
Correction for ‘Mutagenicity of N-acyloxy-N-alkoxyamides as an indicator of DNA intercalation part 1: evidence for naphthalene as a DNA intercalator’ by Tony M. Banks, et al., Org. Biomol. Chem., 2016, 14, 3699–3714.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eebaef0f76ee2743f956802f88113fe
https://pubmed.ncbi.nlm.nih.gov/27357220
https://pubmed.ncbi.nlm.nih.gov/27357220