Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Stephen A Wells"'
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0133372 (2015)
Large-scale conformational change is a common feature in the catalytic cycles of enzymes. Many enzymes function as homodimers with active sites that contain elements from both chains. Symmetric and anti-symmetric cooperative motions in homodimers can
Externí odkaz:
https://doaj.org/article/2a775d972a134ded8a22769c85988db8
Publikováno v:
Noise Control Engineering Journal. 70:207-230
This paper presents a case study for measuring and simulating the vibration and radiated sound for a large complex industrial chiller. We describe a simulation framework based on statistical energy analysis (SEA), which is populated using a hybrid mi
Autor:
Moreica B. Pabbruwe, Thomas J. Joyce, Antoni V.F. Nargol, Nish Shyam, Stephen R. Wells, David J. Langton, Rohan M. Bhalekar, Ryan Collier, Matthew E. Nargol
Publikováno v:
The Bone & Joint Journal. :1791-1801
Aims The aim of this study was to investigate whether wear and backside deformation of polyethylene (PE) tibial inserts may influence the cement cover of tibial trays of explanted total knee arthroplasties (TKAs). Methods At our retrieval centre, we
Publikováno v:
New Journal of Chemistry, vol 45, iss 19
Here, a new tripodal tricarboxylic acid ligand, 4,4′-(4′-(4′-carboxy-[1,1′-biphenyl]-4-yl)-[2,2′:6′,2′′-terpyridine]-5,5′′-diyl)-dibenzoic acid (H3cbt), was synthesised using a three-step convergent strategy. Subsequent reactions
Publikováno v:
CrystEngComm. 23:5615-5623
The study of porous materials under high-pressure conditions is crucial for the understanding and development of structure–property relationships. Zeolites are a diverse class of microporous materials with an extensive range of properties and appli
Publikováno v:
Biomedical Physics & Engineering Express. 9:025003
We propose a technique for metal artefact reduction in digital tomosynthesis reconstruction. Although the problem was addressed earlier in the literature, we suggest another approach, which is, in our opinion, simpler, and easier to implement. It is
Autor:
Jean M. H. van den Elsen, Hannah B. L. Jones, Omar Kassaar, Michael J Knight, Christina E. Gulácsy, Andrew G. Watts, Rachel E Woolley, Stephen A. Wells, Stuart Parsons, Elizabeth Rodriguez, Polly Phaal, Andreia Marques, Anthony Kwok, Alison Turner, John O'Hara, Christopher R. Pudney, Leo A Bowsher, Kieran Dawkins
Publikováno v:
Biochemical Journal
Among the major challenges in the development of biopharmaceuticals are structural heterogeneity and aggregation. The development of a successful therapeutic monoclonal antibody (mAb) requires both a highly active and also stable molecule. Whilst a r
Autor:
Aswin Doekhie, Asel Sartbaeva, Stephen A. Wells, Karen J. Edler, A. P. Silve, Andrew J. Smith, Kevin J. Marchbank, Rajeev Dattani, Yun-Chu Chen, Francoise Koumanov, Yang Yang, J.M.H. van den Elsen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
'Scientific Reports ', vol: 10, pages: 9243-1-9243-9 (2020)
Scientific Reports
'Scientific Reports ', vol: 10, pages: 9243-1-9243-9 (2020)
Scientific Reports
Our recently developed ensilication approach can physically stabilize proteins in silica without use of a pre-formed particle matrix. Stabilisation is done by tailor fitting individual proteins with a silica coat using a modified sol-gel process. Bio
Autor:
Harley L. Worthy, D. Dafydd Jones, Stephen A. Wells, Husam Sabah Auhim, Christopher R. Pudney, Hesham Saeed, Nehad Noby, Samuel Winter, Pierre J. Rizkallah, Amira M. Embaby, Ahmed Hussein
Publikováno v:
Open Biology, Vol 11, Iss 12 (2021)
Open Biology
Open Biology
Here we determined the structure of a cold active family IV esterase (EstN7) cloned from Bacillus cohnii strain N1. EstN7 is a dimer with a classical α/β hydrolase fold. It has an acidic surface that is thought to play a role in cold-adaption by re
Publikováno v:
Harm Reduction Journal, Vol 18, Iss 1, Pp 1-2 (2021)