Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Stephen A Renshaw"'
Autor:
Josie F Gibson, Aleksandra Bojarczuk, Robert J Evans, Alfred Alinafe Kamuyango, Richard Hotham, Anne K Lagendijk, Benjamin M Hogan, Philip W Ingham, Stephen A Renshaw, Simon A Johnston
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010389 (2022)
Meningitis caused by infectious pathogens is associated with vessel damage and infarct formation, however the physiological cause is often unknown. Cryptococcus neoformans is a human fungal pathogen and causative agent of cryptococcal meningitis, whe
Externí odkaz:
https://doaj.org/article/3b91dae0d9c44945a33055a707079f72
Autor:
Josie F Gibson, Grace R Pidwill, Oliver T Carnell, Bas G J Surewaard, Daria Shamarina, Joshua A F Sutton, Charlotte Jeffery, Aurélie Derré-Bobillot, Cristel Archambaud, Matthew K Siggins, Eric J G Pollitt, Simon A Johnston, Pascale Serror, Shiranee Sriskandan, Stephen A Renshaw, Simon J Foster
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009880 (2021)
Staphylococcus aureus is a human commensal organism and opportunist pathogen, causing potentially fatal disease. The presence of non-pathogenic microflora or their components, at the point of infection, dramatically increases S. aureus pathogenicity,
Externí odkaz:
https://doaj.org/article/589ad2747e0c478eacd842d8f79203f3
Autor:
Hannah M Isles, Catherine A Loynes, Sultan Alasmari, Fu Chuen Kon, Katherine M Henry, Anastasia Kadochnikova, Jack Hales, Clare F Muir, Maria-Cristina Keightley, Visakan Kadirkamanathan, Noémie Hamilton, Graham J Lieschke, Stephen A Renshaw, Philip M Elks
Publikováno v:
eLife, Vol 10 (2021)
Neutrophils are rapidly recruited to inflammatory sites where their coordinated migration forms clusters, a process termed neutrophil swarming. The factors that modulate early stages of neutrophil swarming are not fully understood, requiring the deve
Externí odkaz:
https://doaj.org/article/d4579f2c9a1845eca0b84e65f16d27ae
Autor:
Joshua A F Sutton, Oliver T Carnell, Lucia Lafage, Joe Gray, Jacob Biboy, Josie F Gibson, Eric J G Pollitt, Simone C Tazoll, William Turnbull, Natalia H Hajdamowicz, Bartłomiej Salamaga, Grace R Pidwill, Alison M Condliffe, Stephen A Renshaw, Waldemar Vollmer, Simon J Foster
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009468 (2021)
Peptidoglycan is the major structural component of the Staphylococcus aureus cell wall, in which it maintains cellular integrity, is the interface with the host, and its synthesis is targeted by some of the most crucial antibiotics developed. Despite
Externí odkaz:
https://doaj.org/article/fcebc94d5e2540bd8ac9e1aa6695335c
Autor:
Robert J Evans, Katherine Pline, Catherine A Loynes, Sarah Needs, Maceler Aldrovandi, Jens Tiefenbach, Ewa Bielska, Rachel E Rubino, Christopher J Nicol, Robin C May, Henry M Krause, Valerie B O'Donnell, Stephen A Renshaw, Simon A Johnston
Publikováno v:
PLoS Pathogens, Vol 16, Iss 11, p e1009058 (2020)
[This corrects the article DOI: 10.1371/journal.ppat.1007597.].
Externí odkaz:
https://doaj.org/article/22138a71e80440478697917cedc11f4d
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240231 (2020)
During inflammation, dysregulated neutrophil behaviour can play a major role in a range of chronic inflammatory diseases, for many of which current treatments are generally ineffective. Recently, specific naturally occurring tanshinones have shown pr
Externí odkaz:
https://doaj.org/article/9fa84250981447c8938b7344ef0abddb
Autor:
Atiqur Rahman, Katherine M Henry, Kimberly D Herman, Alfred AR Thompson, Hannah M Isles, Claudia Tulotta, David Sammut, Julien JY Rougeot, Nika Khoshaein, Abigail E Reese, Kathryn Higgins, Caroline Tabor, Ian Sabroe, William J Zuercher, Caroline O Savage, Annemarie H Meijer, Moira KB Whyte, David H Dockrell, Stephen A Renshaw, Lynne R Prince
Publikováno v:
eLife, Vol 8 (2019)
Neutrophilic inflammation with prolonged neutrophil survival is common to many inflammatory conditions, including chronic obstructive pulmonary disease (COPD). There are few specific therapies that reverse neutrophilic inflammation, but uncovering me
Externí odkaz:
https://doaj.org/article/fe7fcfe76891424e9fe5d095f6489f95
Autor:
Robert J Evans, Katherine Pline, Catherine A Loynes, Sarah Needs, Maceler Aldrovandi, Jens Tiefenbach, Ewa Bielska, Rachel E Rubino, Christopher J Nicol, Robin C May, Henry M Krause, Valerie B O'Donnell, Stephen A Renshaw, Simon A Johnston
Publikováno v:
PLoS Pathogens, Vol 15, Iss 3, p e1007597 (2019)
Cryptococcus neoformans is one of the leading causes of invasive fungal infection in humans worldwide. C. neoformans uses macrophages as a proliferative niche to increase infective burden and avoid immune surveillance. However, the specific mechanism
Externí odkaz:
https://doaj.org/article/1a08a7430145486bae0ce55dcf6c2043
Autor:
Kyle D Buchan, Tomasz K Prajsnar, Nikolay V Ogryzko, Nienke W M de Jong, Michiel van Gent, Julia Kolata, Simon J Foster, Jos A G van Strijp, Stephen A Renshaw
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215592 (2019)
The neutrophil enzyme myeloperoxidase (MPO) is a major enzyme made by neutrophils to generate antimicrobial and immunomodulatory compounds, notably hypochlorous acid (HOCl), amplifying their capacity for destroying pathogens and regulating inflammati
Externí odkaz:
https://doaj.org/article/2da189fc572646f5a55e6eeaad1a7bde
Autor:
Mark Schiebler, Karen Brown, Krisztina Hegyi, Sandra M Newton, Maurizio Renna, Lucy Hepburn, Catherine Klapholz, Sarah Coulter, Andres Obregón‐Henao, Marcela Henao Tamayo, Randall Basaraba, Beate Kampmann, Katherine M Henry, Joseph Burgon, Stephen A Renshaw, Angeleen Fleming, Robert R Kay, Karen E Anderson, Phillip T Hawkins, Diane J Ordway, David C Rubinsztein, Rodrigo Andres Floto
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 2, Pp 127-139 (2014)
Abstract Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse by the spread of multidrug resistance. We therefore examined whether stimulating intracellular killing of mycobacteria through pharmacological enhancement
Externí odkaz:
https://doaj.org/article/ada27d1f952241569b2948040684763a