Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Stephen A Renshaw"'
Autor:
Joana Alves, Manouk Vrieling, Natalie Ring, Gonzalo Yebra, Amy Pickering, Tomasz K. Prajsnar, Stephen A. Renshaw, J. Ross Fitzgerald
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Staphylococcus aureus is a major pathogen associated with important diseases in humans and animals. Macrophages are a key component of the innate immune response to S. aureus infection and play a major role in disease outcomes. To investigat
Externí odkaz:
https://doaj.org/article/8bc49965ec104d2fa6c918073ae5e90e
Autor:
Grace R. Pidwill, Josie F. Pyrah, Joshua A. F. Sutton, Alex Best, Stephen A. Renshaw, Simon J. Foster
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Staphylococcus aureus is a human commensal and also an opportunist pathogen causing life threatening infections. During S. aureus disease, the abscesses that characterise infection can be clonal, whereby a large bacterial population is found
Externí odkaz:
https://doaj.org/article/be9030a97869411792d99ab1fb4dbab1
Autor:
Ibrahim Jubber, Duncan R. Morhardt, Jonathan Griffin, Marcus G. Cumberbatch, Maggie Glover, Yang Zheng, Ishtiaq Rehman, Catherine A. Loynes, Syed A. Hussain, Stephen A. Renshaw, Steven D. Leach, Vincent T. Cunliffe, James W. F. Catto
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 7 (2023)
Externí odkaz:
https://doaj.org/article/882eef581347482bb2e37309b1667130
Autor:
Pam S. Ellis, Raquel R. Martins, Emily J. Thompson, Asma Farhat, Stephen A. Renshaw, Catarina M. Henriques
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-23 (2022)
Abstract Background Telomerase, the enzyme capable of elongating telomeres, is usually restricted in human somatic cells, which contributes to progressive telomere shortening with cell-division and ageing. T and B-cells cells are somatic cells that c
Externí odkaz:
https://doaj.org/article/bf803312df66482381e58b06972e25fa
Autor:
Stone Elworthy, Holly A. Rutherford, Tomasz K. Prajsnar, Noémie M. Hamilton, Katja Vogt, Stephen A. Renshaw, Alison M. Condliffe
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/196851044d0c4387b4e74b482b2dc3aa
Autor:
Kimberly D. Herman, Carl G. Wright, Helen M. Marriott, Sam C. McCaughran, Kieran A. Bowden, Mark O. Collins, Stephen A. Renshaw, Lynne R. Prince
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Dysregulated neutrophilic inflammation can be highly destructive in chronic inflammatory diseases due to prolonged neutrophil lifespan and continual release of histotoxic mediators in inflamed tissues. Therapeutic induction of neutrophil apoptosis, a
Externí odkaz:
https://doaj.org/article/3b6a66ae4ab6401e9ef5f5cc7bbfbef5
Autor:
Josie F. Gibson, Aleksandra Bojarczuk, Robert J. Evans, Alfred Alinafe Kamuyango, Richard Hotham, Anne K. Lagendijk, Benjamin M. Hogan, Philip W. Ingham, Stephen A. Renshaw, Simon A. Johnston
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4 (2022)
Meningitis caused by infectious pathogens is associated with vessel damage and infarct formation, however the physiological cause is often unknown. Cryptococcus neoformans is a human fungal pathogen and causative agent of cryptococcal meningitis, whe
Externí odkaz:
https://doaj.org/article/9a0f3facc19348eb8e32b4c945c9e636
Autor:
Holly A. Rutherford, Amy Clarke, Emily V. Chambers, Jessica J. Petts, Euan G. Carson, Hannah M. Isles, Alejandra Duque-Jaramillo, Stephen A. Renshaw, Jean-Pierre Levraud, Noémie Hamilton
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 4 (2022)
Endogenous retroviruses (ERVs) are fossils left in our genome from retrovirus infections of the past. Their sequences are part of every vertebrate genome and their random integrations are thought to have contributed to evolution. Although ERVs are ma
Externí odkaz:
https://doaj.org/article/41b7b9994ecb41a683d8d684f5ce4a0b
Autor:
Josie F Gibson, Grace R Pidwill, Oliver T Carnell, Bas G J Surewaard, Daria Shamarina, Joshua A F Sutton, Charlotte Jeffery, Aurélie Derré-Bobillot, Cristel Archambaud, Matthew K Siggins, Eric J G Pollitt, Simon A Johnston, Pascale Serror, Shiranee Sriskandan, Stephen A Renshaw, Simon J Foster
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009880 (2021)
Staphylococcus aureus is a human commensal organism and opportunist pathogen, causing potentially fatal disease. The presence of non-pathogenic microflora or their components, at the point of infection, dramatically increases S. aureus pathogenicity,
Externí odkaz:
https://doaj.org/article/589ad2747e0c478eacd842d8f79203f3
Autor:
Hannah M Isles, Catherine A Loynes, Sultan Alasmari, Fu Chuen Kon, Katherine M Henry, Anastasia Kadochnikova, Jack Hales, Clare F Muir, Maria-Cristina Keightley, Visakan Kadirkamanathan, Noémie Hamilton, Graham J Lieschke, Stephen A Renshaw, Philip M Elks
Publikováno v:
eLife, Vol 10 (2021)
Neutrophils are rapidly recruited to inflammatory sites where their coordinated migration forms clusters, a process termed neutrophil swarming. The factors that modulate early stages of neutrophil swarming are not fully understood, requiring the deve
Externí odkaz:
https://doaj.org/article/d4579f2c9a1845eca0b84e65f16d27ae