Zobrazeno 1 - 10
of 944
pro vyhledávání: '"Stephen A, Ward"'
Autor:
Joseph A. Daccache, Francis Eng, Lei Cao, Ning Ma, Stephen C. Ward, Thomas Schiano, Mark Miller, Daniel Herron, Anthony V. Azzara, Steven S. Pullen, Paolo Guarnieri, Costica Aloman, Andrea D. Branch
Publikováno v:
Clinical and Translational Discovery, Vol 4, Iss 5, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/dfe5f6ac40824995975fd62165fa8afb
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/756cdf40048a4adf9198a3e80e3984f8
Autor:
Stephen V. Ward
Publikováno v:
Angles, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/cd325379f6fb4649b0ebe8ed69a5bd33
Autor:
Agata Stodolna, Miao He, Mahesh Vasipalli, Zoya Kingsbury, Jennifer Becq, Joanne D. Stockton, Mark P. Dilworth, Jonathan James, Toju Sillo, Daniel Blakeway, Stephen T. Ward, Tariq Ismail, Mark T. Ross, Andrew D. Beggs
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract Background Clinical-grade whole-genome sequencing (cWGS) has the potential to become the standard of care within the clinic because of its breadth of coverage and lack of bias towards certain regions of the genome. Colorectal cancer presents
Externí odkaz:
https://doaj.org/article/00cb0ed19ab64cdb92fa418f9c62f4a2
Autor:
Aekkarin Klinkhamhom, Supattra Glaharn, Charit Srisook, Sumate Ampawong, Srivicha Krudsood, Stephen A. Ward, Parnpen Viriyavejakul
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-9 (2020)
Abstract Background Pulmonary oedema (PE) is a serious complication of Plasmodium falciparum malaria which can lead to acute lung injury in severe cases. Lung macrophages are activated during malaria infection due to a complex host-immune response. T
Externí odkaz:
https://doaj.org/article/35ec0c5bea2a46d09be53953610652e9
Autor:
Bojan Losic, Amanda J. Craig, Carlos Villacorta-Martin, Sebastiao N. Martins-Filho, Nicholas Akers, Xintong Chen, Mehmet E. Ahsen, Johann von Felden, Ismail Labgaa, Delia DʹAvola, Kimaada Allette, Sergio A. Lira, Glaucia C. Furtado, Teresa Garcia-Lezana, Paula Restrepo, Ashley Stueck, Stephen C. Ward, Maria I. Fiel, Spiros P. Hiotis, Ganesh Gunasekaran, Daniela Sia, Eric E. Schadt, Robert Sebra, Myron Schwartz, Josep M. Llovet, Swan Thung, Gustavo Stolovitzky, Augusto Villanueva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Immune-mediated selection pressures impact the clonal evolution of tumours. Here, in hepatocellular carcinoma the authors map spatio-temporal interactions between tumor and immune cells, highlighting the regulatory substrate of intra-tumoural heterog
Externí odkaz:
https://doaj.org/article/b7e9387e6d0443a18b41f98ca9cd0d20
Autor:
Sarah A. Penny, Jennifer G. Abelin, Stacy A. Malaker, Paisley T. Myers, Abu Z. Saeed, Lora G. Steadman, Dina L. Bai, Stephen T. Ward, Jeffrey Shabanowitz, Donald F. Hunt, Mark Cobbold
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
There is a pressing need for novel immunotherapeutic targets in colorectal cancer (CRC). Cytotoxic T cell infiltration is well established as a key prognostic indicator in CRC, and it is known that these tumor infiltrating lymphocytes (TILs) target a
Externí odkaz:
https://doaj.org/article/c061e36b679342809afb621a520a51ca
Autor:
Grazia Camarda, Piyaporn Jirawatcharadech, Richard S. Priestley, Ahmed Saif, Sandra March, Michael H. L. Wong, Suet Leung, Alex B. Miller, David A. Baker, Pietro Alano, Mark J. I. Paine, Sangeeta N. Bhatia, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Primaquine (PQ) is a widely used anti-malaria drug, but its mechanism of action is unclear. Here, Camarda et al. show that PQ’s activity against liver and sexual Plasmodium stages depends on generation of hydroxylated-PQ metabolites (OH-PQm), which
Externí odkaz:
https://doaj.org/article/53df786506df4fffaf54431621d57eba
Autor:
Rachel H. Clare, Catherine Bardelle, Paul Harper, W. David Hong, Ulf Börjesson, Kelly L. Johnston, Matthew Collier, Laura Myhill, Andrew Cassidy, Darren Plant, Helen Plant, Roger Clark, Darren A. N. Cook, Andrew Steven, John Archer, Paul McGillan, Sitthivut Charoensutthivarakul, Jaclyn Bibby, Raman Sharma, Gemma L. Nixon, Barton E. Slatko, Lindsey Cantin, Bo Wu, Joseph Turner, Louise Ford, Kirsty Rich, Mark Wigglesworth, Neil G. Berry, Paul M. O’Neill, Mark J. Taylor, Stephen A. Ward
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chem
Externí odkaz:
https://doaj.org/article/4cb4bba947a8460babf1f27b9cb22a73
Autor:
Kangsa Amporndanai, Nattapon Pinthong, Paul M. O’Neill, W. David Hong, Richard K. Amewu, Chandrakala Pidathala, Neil G. Berry, Suet C. Leung, Stephen A. Ward, Giancarlo A. Biagini, S. Samar Hasnain, Svetlana V. Antonyuk
Publikováno v:
Biology, Vol 11, Iss 8, p 1109 (2022)
Antimalarials targeting the ubiquinol-oxidation (Qo) site of the Plasmodium falciparum bc1 complex, such as atovaquone, have become less effective due to the rapid emergence of resistance linked to point mutations in the Qo site. Recent findings show
Externí odkaz:
https://doaj.org/article/b74084f8e68b4a56bee023bd1e647e27