Zobrazeno 1 - 10
of 272
pro vyhledávání: '"Stephen A, Vernon"'
Autor:
Andy Tran, Andy Wang, Jamie Mickaill, Dario Strbenac, Mark Larance, Stephen T. Vernon, Stuart M. Grieve, Gemma A. Figtree, Ellis Patrick, Jean Yee Hwa Yang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract In the enduring challenge against disease, advancements in medical technology have empowered clinicians with novel diagnostic platforms. Whilst in some cases, a single test may provide a confident diagnosis, often additional tests are requir
Externí odkaz:
https://doaj.org/article/e78c45ecc8384f248fa19ebfd1922637
Autor:
Weiqian Eugene Lee, Elijah Genetzakis, Giannie Barsha, Joshua Vescovi, Carmen Mifsud, Stephen T. Vernon, Tung Viet Nguyen, Michael P. Gray, Stuart M. Grieve, Gemma A. Figtree
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1308 (2024)
Background and Aims: Myeloperoxidase (MPO) plays a critical role in the innate immune response and has been suggested to be a surrogate marker of oxidative stress and inflammation, with elevated levels implicated in cardiovascular diseases, such as a
Externí odkaz:
https://doaj.org/article/f4d5eaa2e8ce49f58d888198e17905f3
Autor:
Stephen T. Vernon, Stuart Brentnall, Danielle J Currie, Cindy Peng, Michael P. Gray, Giordano Botta, Deo Mujwara, Stephen J. Nicholls, Stuart M. Grieve, Julie Redfern, Clara Chow, Jean-Frederic Levesque, Peter J. Meikle, Garry Jennings, Zanfina Ademi, Andrew Wilson, Gemma A. Figtree
Publikováno v:
American Journal of Preventive Cardiology, Vol 18, Iss , Pp 100672- (2024)
Background: Primary prevention programs utilising traditional risk scores fail to identify all individuals who suffer acute cardiovascular events. We aimed to model the impact and cost effectiveness of incorporating a Polygenic risk scores (PRS) into
Externí odkaz:
https://doaj.org/article/b786deb82829480a8118d138be0a781e
Autor:
Katharine A. Bate, Elijah Genetzakis, Joshua Vescovi, Michael P. Gray, David S. Celermajer, Helen M. McGuire, Stuart M. Grieve, Stephen T. Vernon, Siân P. Cartland, Jean Y. Yang, Mary M. Kavurma, Gemma A. Figtree
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1119 (2024)
The risk-factor-based prediction of atherosclerotic coronary artery disease (CAD) remains suboptimal, particularly in the absence of any of the standard modifiable cardiovascular risk factors (SMuRFs), making the discovery of biomarkers that correlat
Externí odkaz:
https://doaj.org/article/8cc95d4df88b46e6b2d39e95007bbedc
Autor:
Genevieve Coorey, Gemma A. Figtree, David F. Fletcher, Victoria J. Snelson, Stephen Thomas Vernon, David Winlaw, Stuart M. Grieve, Alistair McEwan, Jean Yee Hwa Yang, Pierre Qian, Kieran O’Brien, Jessica Orchard, Jinman Kim, Sanjay Patel, Julie Redfern
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-12 (2022)
Abstract Potential benefits of precision medicine in cardiovascular disease (CVD) include more accurate phenotyping of individual patients with the same condition or presentation, using multiple clinical, imaging, molecular and other variables to gui
Externí odkaz:
https://doaj.org/article/a89c12ecf5d94282a867fd26e2f2c8ee
Autor:
Adam S. Chan, Songhua Wu, Stephen T. Vernon, Owen Tang, Gemma A. Figtree, Tongliang Liu, Jean Y.H. Yang, Ellis Patrick
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106633- (2023)
Summary: Cardiovascular disease remains a leading cause of mortality with an estimated half a billion people affected in 2019. However, detecting signals between specific pathophysiology and coronary plaque phenotypes using complex multi-omic discove
Externí odkaz:
https://doaj.org/article/1e3bd3bd2ce74709add12efe4fe44c71
Autor:
Katharine A Kott, Adam S Chan, Stephen T Vernon, Thomas Hansen, Taiyun Kim, Macha deDreu, Bavani Gunasegaran, Andrew J Murphy, Ellis Patrick, Peter J Psaltis, Stuart M Grieve, Jean Y Yang, Barbara Fazekas de St Groth, Helen M McGuire, Gemma A Figtree
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 11, Pp n/a-n/a (2023)
Abstract Objective The importance of inflammation in atherosclerosis is well accepted, but the role of the adaptive immune system is not yet fully understood. To further explore this, we assessed the circulating immune cell profile of patients with c
Externí odkaz:
https://doaj.org/article/c6896394e4c5467bb8255df0f5093c80
Autor:
Katharine A. Kott, Elijah Genetzakis, Michael P. Gray, Peter Hansen, Helen M. McGuire, Jean Y. Yang, Stuart M. Grieve, Stephen T. Vernon, Gemma A. Figtree
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1187 (2023)
Risk-factor-based scoring systems for atherosclerotic coronary artery disease (CAD) remain concerningly inaccurate at the level of the individual and would benefit from the addition of biomarkers that correlate with atherosclerosis burden directly. W
Externí odkaz:
https://doaj.org/article/e41e7fd4fd31493d8967924070904f7f
Autor:
Taiyun Kim, Owen Tang, Stephen T. Vernon, Katharine A. Kott, Yen Chin Koay, John Park, David E. James, Stuart M. Grieve, Terence P. Speed, Pengyi Yang, Gemma A. Figtree, John F. O’Sullivan, Jean Yee Hwa Yang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Mass spectrometry-based metabolomics is a powerful method for profiling large clinical cohorts but batch variations can obscure biologically meaningful differences. Here, the authors develop a computational workflow that removes unwanted data variati
Externí odkaz:
https://doaj.org/article/b9f05e117dcb4f2a9c9c505e343dfa63
Autor:
Jawad Mazhar, Kathrine Ekström, Rebecca Kozor, Stuart M. Grieve, Lars Nepper-Christensen, Kiril A. Ahtarovski, Henning Kelbæk, Dan E. Høfsten, Lars Køber, Niels Vejlstrup, Stephen T. Vernon, Thomas Engstrøm, Jacob Lønborg, Gemma A. Figtree
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
IntroductionA higher 30-day mortality has been observed in patients with first-presentation ST elevation myocardial infarction (STEMI) who have no standard modifiable cardiovascular risk factors (SMuRFs), i. e., diabetes, hypertension, hyperlipidemia
Externí odkaz:
https://doaj.org/article/cb86da18c5644dda845c775a3c5a8e47