Zobrazeno 1 - 10
of 350
pro vyhledávání: '"Stephen R. Plymate"'
Autor:
Song Yi Bae, Hannah E. Bergom, Abderrahman Day, Joseph T. Greene, Zoi E. Sychev, Gabrianne Larson, Eva Corey, Stephen R. Plymate, Tanya S. Freedman, Justin H. Hwang, Justin M. Drake
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer. NEPC is characterized by the loss of androgen receptor (AR) signaling and transdifferentiation toward small-cell neuroendocrine (SCN) phenotypes, which results i
Externí odkaz:
https://doaj.org/article/3e48ddb167a545a593cf9fd00b156061
Autor:
Lauren Brady, Michelle Kriner, Ilsa Coleman, Colm Morrissey, Martine Roudier, Lawrence D. True, Roman Gulati, Stephen R. Plymate, Zoey Zhou, Brian Birditt, Rhonda Meredith, Gary Geiss, Margaret Hoang, Joseph Beechem, Peter S. Nelson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The inter- and intra-tumor heterogeneity of metastatic prostate cancer (mPC) is underexplored. Here the authors use Digital Spatial Profiling to study gene and protein expression heterogeneity in 27 mPC patients, finding variation in associated pathw
Externí odkaz:
https://doaj.org/article/e4f2a14a1c564697b67f91b5bef0c54e
Autor:
Stephen Y. C. Choi, Caroline Fidalgo Ribeiro, Yuzhuo Wang, Massimo Loda, Stephen R. Plymate, Takuma Uo
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1590 (2022)
There is an urgent need for exploring new actionable targets other than androgen receptor to improve outcome from lethal castration-resistant prostate cancer. Tumor metabolism has reemerged as a hallmark of cancer that drives and supports oncogenesis
Externí odkaz:
https://doaj.org/article/97827942c8504da9b13c9ad5b3361fa1
Publikováno v:
Cancer Treatment and Research Communications, Vol 28, Iss , Pp 100218- (2021)
Externí odkaz:
https://doaj.org/article/1c7210478d224aa39da90c415bc6c6fd
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Metabolic reprogramming is associated with re/activation and antagonism of androgen receptor (AR) signaling that drives prostate cancer (PCa) progression to castration resistance, respectively. In particular, AR signaling influences the fates of citr
Externí odkaz:
https://doaj.org/article/87e0ed967c4b41efacda68679632678e
Autor:
Adam G. Sowalsky, Ines Figueiredo, Rosina T. Lis, Ilsa Coleman, Bora Gurel, Denisa Bogdan, Wei Yuan, Joshua W. Russo, John R. Bright, Nichelle C. Whitlock, Shana Y. Trostel, Anson T. Ku, Radhika A. Patel, Lawrence D. True, Jonathan Welti, Juan M. Jimenez-Vacas, Daniel Nava Rodrigues, Ruth Riisnaes, Antje Neeb, Cynthia T. Sprenger, Amanda Swain, Scott Wilkinson, Fatima Karzai, William L. Dahut, Steven P. Balk, Eva Corey, Peter S. Nelson, Michael C. Haffner, Stephen R. Plymate, Johann S. de Bono, Adam Sharp
Publikováno v:
Clin Cancer Res
Purpose: Therapies targeting the androgen receptor (AR) have improved the outcome for patients with castration-sensitive prostate cancer (CSPC). Expression of the constitutively active AR splice variant-7 (AR-V7) has shown clinical utility as a predi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb056e552b2301f63ba44bb13d249e4
https://doi.org/10.1158/1078-0432.ccr-22-0851
https://doi.org/10.1158/1078-0432.ccr-22-0851
Autor:
Arul M. Chinnaiyan, Felix Y. Feng, Shaomeng Wang, Nora M. Navone, Stephen R. Plymate, June Escara-Wilke, Ingrid J. Apel, Pranathi M. Krishnamurthy, Vijaya L. Dommeti, Kari Wilder-Romans, Irfan A. Asangani
Direct comparison of various BET inhibitors in prostate cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054e977023690453334ed18abb56aba5
https://doi.org/10.1158/1541-7786.22514317
https://doi.org/10.1158/1541-7786.22514317
Autor:
Arul M. Chinnaiyan, Felix Y. Feng, Shaomeng Wang, Nora M. Navone, Stephen R. Plymate, June Escara-Wilke, Ingrid J. Apel, Pranathi M. Krishnamurthy, Vijaya L. Dommeti, Kari Wilder-Romans, Irfan A. Asangani
De-recruitment of BRD2/3/4 from the SRSF1 and U2AF1 promoter by JQ1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819e8d59b6ba003ad07470d9ee744e45
https://doi.org/10.1158/1541-7786.22514314.v1
https://doi.org/10.1158/1541-7786.22514314.v1
Autor:
Arul M. Chinnaiyan, Felix Y. Feng, Shaomeng Wang, Nora M. Navone, Stephen R. Plymate, June Escara-Wilke, Ingrid J. Apel, Pranathi M. Krishnamurthy, Vijaya L. Dommeti, Kari Wilder-Romans, Irfan A. Asangani
Supplemental Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296a106703e23bc203cb887760436c4f
https://doi.org/10.1158/1541-7786.22514305
https://doi.org/10.1158/1541-7786.22514305
Autor:
Arul M. Chinnaiyan, Felix Y. Feng, Shaomeng Wang, Nora M. Navone, Stephen R. Plymate, June Escara-Wilke, Ingrid J. Apel, Pranathi M. Krishnamurthy, Vijaya L. Dommeti, Kari Wilder-Romans, Irfan A. Asangani
Antibodies and PCR Primers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1481eb367b7728ff991717cc9dfdedb
https://doi.org/10.1158/1541-7786.22514302
https://doi.org/10.1158/1541-7786.22514302