Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Stephen F. Traynelis"'
Autor:
Chad R. Camp, Anna Vlachos, Chiara Klöckner, Ilona Krey, Tue G. Banke, Nima Shariatzadeh, Sarah M. Ruggiero, Peter Galer, Kristen L. Park, Adam Caccavano, Sarah Kimmel, Xiaoqing Yuan, Hongjie Yuan, Ingo Helbig, Tim A. Benke, Johannes R. Lemke, Kenneth A. Pelkey, Chris J. McBain, Stephen F. Traynelis
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate a calcium-permeable component to fast excitatory neurotransmission. NMDARs are heterotetrameric assemblies of two obligate GluN1 subunits (G
Externí odkaz:
https://doaj.org/article/cf7691bd122c40aa8eaf85252a89fb91
Autor:
Yuchen Xu, Rui Song, Wenjuan Chen, Katie Strong, Daniel Shrey, Satyanarayana Gedela, Stephen F. Traynelis, Guojun Zhang, Hongjie Yuan
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 7, Pp 1480-1494 (2021)
Abstract Objective Genetic variants in the GRIN genes that encode N‐methyl‐D‐aspartate receptor (NMDAR) subunits have been identified in various neurodevelopmental disorders, including epilepsy. We identified a GRIN1 variant from an individual
Externí odkaz:
https://doaj.org/article/e3e0e778e7af4ca384fd1ce4a447f108
Autor:
Jin Zhang, Weiting Tang, Nidhi K. Bhatia, Yuchen Xu, Nabina Paudyal, Ding Liu, Sukhan Kim, Rui Song, Wenshu XiangWei, Gil Shaulsky, Scott J. Myers, William Dobyns, Vasanthi Jayaraman, Stephen F. Traynelis, Hongjie Yuan, Xiuhua Bozarth
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
N-Methyl-D-aspartate receptors (NMDARs) are highly expressed in brain and play important roles in neurodevelopment and various neuropathologic conditions. Here, we describe a new phenotype in an individual associated with a novel de novo deleterious
Externí odkaz:
https://doaj.org/article/35b7af089b1f4c96ab402ee40d573afb
Autor:
Michael C. Regan, Zongjian Zhu, Hongjie Yuan, Scott J. Myers, Dave S. Menaldino, Yesim A. Tahirovic, Dennis C. Liotta, Stephen F. Traynelis, Hiro Furukawa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Context-dependent inhibition of NMDA receptors has important therapeutic implications for treatment of neurological diseases. Here, the authors use structural biology and biophysics to describe the basis for pH-dependent inhibition for a class of all
Externí odkaz:
https://doaj.org/article/6b226358d0264cea8bca51d4ed185d0d
Autor:
Lynnea D. Harris, Michael C. Regan, Scott J. Myers, Kelsey A. Nocilla, Nicholas S. Akins, Yesim A. Tahirovic, Lawrence J. Wilson, Ray Dingledine, Hiro Furukawa, Stephen F. Traynelis, Dennis C. Liotta
Publikováno v:
ACS Chemical Neuroscience. 14:917-935
Autor:
Stefanie Brock, Annie Laquerriere, Florent Marguet, Scott J Myers, Yuan Hongjie, Diana Baralle, Tim Vanderhasselt, Katrien Stouffs, Kathelijn Keymolen, Sukhan Kim, James Allen, Gil Shaulsky, Jamel Chelly, Pascale Marcorelle, Jacqueline Aziza, Laurent Villard, Elise Sacaze, Marie C Y de Wit, Martina Wilke, Grazia Maria Simonetta Mancini, Ute Hehr, Derek Lim, Sahar Mansour, Stephen F Traynelis, Claire Beneteau, Marie Denis-Musquer, Anna C Jansen, Andrew E Fry, Nadia Bahi-Buisson
Publikováno v:
Journal of medical genetics
Journal of Medical Genetics, 60(2), 183-192. BMJ Publishing Group
Journal of Medical Genetics
Journal of Medical Genetics, 2022, pp.jmedgenet-2021-107971. ⟨10.1136/jmedgenet-2021-107971⟩
Journal of Medical Genetics, 60(2), 183-192. BMJ Publishing Group
Journal of Medical Genetics
Journal of Medical Genetics, 2022, pp.jmedgenet-2021-107971. ⟨10.1136/jmedgenet-2021-107971⟩
BackgroundMalformations of cortical development (MCDs) have been reported in a subset of patients with pathogenic heterozygous variants inGRIN1orGRIN2B, genes which encode for subunits of the N-methyl-D-aspartate receptor (NMDAR). The aim of this stu
Autor:
Carolina Montañez-Miranda, Riley E. Perszyk, Nicholas H. Harbin, Jennifer Okalova, Suneela Ramineni, Stephen F. Traynelis, John R. Hepler
Publikováno v:
Molecular Pharmacology. 103:21-37
Autor:
Scott J Myers, Hongjie Yuan, Jing-Qiong Kang, Francis Chee Kuan Tan, Stephen F Traynelis, Chian-Ming Low
Publikováno v:
F1000Research, Vol 8 (2019)
Rapid advances in sequencing technology have led to an explosive increase in the number of genetic variants identified in patients with neurological disease and have also enabled the assembly of a robust database of variants in healthy individuals. A
Externí odkaz:
https://doaj.org/article/01db0138bf5048dbb3442018b9248bcd
Autor:
Arun Singh, Meagan A. Jenkins, Kenneth J. Burke, Jr., Goichi Beck, Andrew Jenkins, Annalisa Scimemi, Stephen F. Traynelis, Stella M. Papa
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 941-952 (2018)
Dopamine (DA) loss in Parkinson’s disease (PD) alters the function of striatal projection neurons (SPNs) and causes motor deficits, but DA replacement can induce further abnormalities. A key pathological change in animal models and patients is SPN
Externí odkaz:
https://doaj.org/article/aa0dd9bfbdb64e38a7d24fafa33c0931